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ACE (angiotensin I converting enzyme)

Identity

Other namesACE1
CD143
DCP
DCP1
ICH
MVCD3
HGNC (Hugo) ACE
LocusID (NCBI) 1636
Location 17q23.3
Location_base_pair Starts at 61554422 and ends at 61575741 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ACE   2707
Cards
Entrez_Gene (NCBI)ACE  1636  angiotensin I converting enzyme
GeneCards (Weizmann)ACE
Ensembl (Hinxton)ENSG00000159640 [Gene_View]  chr17:61554422-61575741 [Contig_View]  ACE [Vega]
ICGC DataPortalENSG00000159640
AceView (NCBI)ACE
Genatlas (Paris)ACE
WikiGenes1636
SOURCE (Princeton)NM_000789 NM_001178057 NM_152830 NM_152831
Genomic and cartography
GoldenPath (UCSC)ACE  -  17q23.3   chr17:61554422-61575741 +  17q23.3   [Description]    (hg19-Feb_2009)
EnsemblACE - 17q23.3 [CytoView]
Mapping of homologs : NCBIACE [Mapview]
OMIM104300   106180   267430   612624   614519   
Gene and transcription
Genbank (Entrez)AB208971 AK296566 AK300516 AK301988 AK302019
RefSeq transcript (Entrez)NM_000789 NM_001178057 NM_152830 NM_152831
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_011648 NT_010783 NW_001838450 NW_004929407
Consensus coding sequences : CCDS (NCBI)ACE
Cluster EST : UnigeneHs.298469 [ NCBI ]
CGAP (NCI)Hs.298469
Alternative Splicing : Fast-db (Paris)GSHG0012723
Alternative Splicing GalleryENSG00000159640
Gene ExpressionACE [ NCBI-GEO ]     ACE [ SEEK ]   ACE [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP12821 (Uniprot)
NextProtP12821  [Medical]
With graphics : InterProP12821
Splice isoforms : SwissVarP12821 (Swissvar)
Catalytic activity : Enzyme3.2.1.- [ Enzyme-Expasy ]   3.2.1.-3.2.1.- [ IntEnz-EBI ]   3.2.1.- [ BRENDA ]   3.2.1.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Peptidase_M2   
Related proteins : CluSTrP12821
Domain families : Pfam (Sanger)Peptidase_M2 (PF01401)   
Domain families : Pfam (NCBI)pfam01401   
DMDM Disease mutations1636
Blocks (Seattle)P12821
PDB (SRS)1O86    1O8A    1UZE    1UZF    2C6F    2C6N    2IUL    2IUX    2OC2    2XY9    2XYD    2YDM    3BKK    3BKL    3L3N    3NXQ    4APH    4APJ    4BXK    4BZR    4BZS    4C2N    4C2O    4C2P    4C2Q    4C2R    4CA5    4CA6   
PDB (PDBSum)1O86    1O8A    1UZE    1UZF    2C6F    2C6N    2IUL    2IUX    2OC2    2XY9    2XYD    2YDM    3BKK    3BKL    3L3N    3NXQ    4APH    4APJ    4BXK    4BZR    4BZS    4C2N    4C2O    4C2P    4C2Q    4C2R    4CA5    4CA6   
PDB (IMB)1O86    1O8A    1UZE    1UZF    2C6F    2C6N    2IUL    2IUX    2OC2    2XY9    2XYD    2YDM    3BKK    3BKL    3L3N    3NXQ    4APH    4APJ    4BXK    4BZR    4BZS    4C2N    4C2O    4C2P    4C2Q    4C2R    4CA5    4CA6   
PDB (RSDB)1O86    1O8A    1UZE    1UZF    2C6F    2C6N    2IUL    2IUX    2OC2    2XY9    2XYD    2YDM    3BKK    3BKL    3L3N    3NXQ    4APH    4APJ    4BXK    4BZR    4BZS    4C2N    4C2O    4C2P    4C2Q    4C2R    4CA5    4CA6   
Human Protein AtlasENSG00000159640
Peptide AtlasP12821
HPRD00108
IPIIPI00437751   IPI00877100   IPI00028147   IPI01009299   IPI00796552   IPI00909226   
Protein Interaction databases
DIP (DOE-UCLA)P12821
IntAct (EBI)P12821
FunCoupENSG00000159640
BioGRIDACE
InParanoidP12821
Interologous Interaction database P12821
IntegromeDBACE
STRING (EMBL)ACE
Ontologies - Pathways
Ontology : AmiGOkidney development  blood vessel remodeling  angiotensin maturation  angiotensin catabolic process in blood  regulation of renal output by angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  actin binding  endopeptidase activity  carboxypeptidase activity  protein binding  extracellular region  extracellular space  endosome  plasma membrane  plasma membrane  proteolysis  drug binding  regulation of blood pressure  metallopeptidase activity  metallopeptidase activity  peptidyl-dipeptidase activity  peptidyl-dipeptidase activity  zinc ion binding  external side of plasma membrane  regulation of smooth muscle cell migration  integral component of membrane  regulation of vasoconstriction  chloride ion binding  bradykinin receptor binding  mononuclear cell proliferation  regulation of vasodilation  hormone catabolic process  hormone catabolic process  peptide catabolic process  cellular protein metabolic process  arachidonic acid secretion  hematopoietic stem cell differentiation  extracellular vesicular exosome  
Ontology : EGO-EBIkidney development  blood vessel remodeling  angiotensin maturation  angiotensin catabolic process in blood  regulation of renal output by angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  actin binding  endopeptidase activity  carboxypeptidase activity  protein binding  extracellular region  extracellular space  endosome  plasma membrane  plasma membrane  proteolysis  drug binding  regulation of blood pressure  metallopeptidase activity  metallopeptidase activity  peptidyl-dipeptidase activity  peptidyl-dipeptidase activity  zinc ion binding  external side of plasma membrane  regulation of smooth muscle cell migration  integral component of membrane  regulation of vasoconstriction  chloride ion binding  bradykinin receptor binding  mononuclear cell proliferation  regulation of vasodilation  hormone catabolic process  hormone catabolic process  peptide catabolic process  cellular protein metabolic process  arachidonic acid secretion  hematopoietic stem cell differentiation  extracellular vesicular exosome  
Pathways : BIOCARTAAngiotensin-converting enzyme 2 regulates heart function [Genes]   
Pathways : KEGGRenin-angiotensin system    Chagas disease (American trypanosomiasis)    Hypertrophic cardiomyopathy (HCM)   
Protein Interaction DatabaseACE
Wikipedia pathwaysACE
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ACE
SNP (GeneSNP Utah)ACE
SNP : HGBaseACE
Genetic variants : HAPMAPACE
1000_GenomesACE 
ICGC programENSG00000159640 
CONAN: Copy Number AnalysisACE 
Somatic Mutations in Cancer : COSMICACE 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDACE
OMIM104300    106180    267430    612624    614519   
MedgenACE
GENETestsACE
Disease Genetic AssociationACE
Huge Navigator ACE [HugePedia]  ACE [HugeCancerGEM]
Genomic VariantsACE  ACE [DGVbeta]
Exome VariantACE
dbVarACE
ClinVarACE
snp3D : Map Gene to Disease1636
General knowledge
Homologs : HomoloGeneACE
Homology/Alignments : Family Browser (UCSC)ACE
Phylogenetic Trees/Animal Genes : TreeFamACE
Chemical/Protein Interactions : CTD1636
Chemical/Pharm GKB GenePA139
Clinical trialACE
Cancer Resource (Charite)ENSG00000159640
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineACE
iHOPACE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:30:11 CEST 2014

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