ACER2 (alkaline ceramidase 2)

2010-10-01  

Identity

HGNC
LOCATION
9p22.1
LOCUSID
ALIAS
ALKCDase2,ASAH3L
FUSION GENES

Other Information

Locus ID:

NCBI: 340485
MIM: 613492
HGNC: 23675
Ensembl: ENSG00000177076

Variants:

dbSNP: 340485
ClinVar: 340485
TCGA: ENSG00000177076
COSMIC: ACER2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177076ENST00000340967Q5QJU3

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
Metabolic pathwaysKEGGhsa01100
Sphingosine biosynthesisKEGGM00099
Sphingosine biosynthesisKEGGhsa_M00099
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
189458762009Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion.17
292299902018Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2.12
282941572017Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation.11
247089962014Regulation of alkaline ceramidase activity by the c-Src-mediated pathway.2
200898562010Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2).0
206280552010Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells.0
269430392016Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response.0

Citation

Dessen P

ACER2 (alkaline ceramidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51740/acer2