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ACKR2 (atypical chemokine receptor 2)

Identity

Alias_namesCMKBR9
CCBP2
chemokine binding protein 2
Alias_symbol (synonym)CCR10
D6
CCR9
Other aliashD6
HGNC (Hugo) ACKR2
LocusID (NCBI) 1238
Atlas_Id 937
Location 3p22.1  [Link to chromosome band 3p22]
Location_base_pair Starts at 42809472 and ends at 42867283 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACKR2 (3p22.1) / CHST10 (2q11.2)ACKR2 (3p22.1) / RUNX1 (21q22.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACKR2   1565
Cards
Entrez_Gene (NCBI)ACKR2  1238  atypical chemokine receptor 2
AliasesCCBP2; CCR10; CCR9; CMKBR9; 
D6; hD6
GeneCards (Weizmann)ACKR2
Ensembl hg19 (Hinxton)ENSG00000144648 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144648 [Gene_View]  chr3:42809472-42867283 [Contig_View]  ACKR2 [Vega]
ICGC DataPortalENSG00000144648
TCGA cBioPortalACKR2
AceView (NCBI)ACKR2
Genatlas (Paris)ACKR2
WikiGenes1238
SOURCE (Princeton)ACKR2
Genetics Home Reference (NIH)ACKR2
Genomic and cartography
GoldenPath hg38 (UCSC)ACKR2  -     chr3:42809472-42867283 +  3p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACKR2  -     3p22.1   [Description]    (hg19-Feb_2009)
EnsemblACKR2 - 3p22.1 [CytoView hg19]  ACKR2 - 3p22.1 [CytoView hg38]
Mapping of homologs : NCBIACKR2 [Mapview hg19]  ACKR2 [Mapview hg38]
OMIM602648   
Gene and transcription
Genbank (Entrez)AK313561 BC008816 BC011588 BC011631 BC018716
RefSeq transcript (Entrez)NM_001296
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACKR2
Cluster EST : UnigeneHs.146346 [ NCBI ]
CGAP (NCI)Hs.146346
Alternative Splicing GalleryENSG00000144648
Gene ExpressionACKR2 [ NCBI-GEO ]   ACKR2 [ EBI - ARRAY_EXPRESS ]   ACKR2 [ SEEK ]   ACKR2 [ MEM ]
Gene Expression Viewer (FireBrowse)ACKR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1238
GTEX Portal (Tissue expression)ACKR2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00590   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00590  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00590
Splice isoforms : SwissVarO00590
PhosPhoSitePlusO00590
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Ackr2    Chemokine_rcpt    CXCR4/ACKR2    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)ACKR2
DMDM Disease mutations1238
Blocks (Seattle)ACKR2
SuperfamilyO00590
Human Protein AtlasENSG00000144648
Peptide AtlasO00590
HPRD09095
IPIIPI00012180   
Protein Interaction databases
DIP (DOE-UCLA)O00590
IntAct (EBI)O00590
FunCoupENSG00000144648
BioGRIDACKR2
STRING (EMBL)ACKR2
ZODIACACKR2
Ontologies - Pathways
QuickGOO00590
Ontology : AmiGOchemokine receptor activity  scavenger receptor activity  nucleoplasm  early endosome  cytosol  actin filament  plasma membrane  integral component of plasma membrane  receptor-mediated endocytosis  chemotaxis  inflammatory response  immune response  G-protein coupled receptor signaling pathway  multicellular organism development  C-C chemokine binding  nuclear membrane  intracellular membrane-bounded organelle  recycling endosome  chemokine-mediated signaling pathway  
Ontology : EGO-EBIchemokine receptor activity  scavenger receptor activity  nucleoplasm  early endosome  cytosol  actin filament  plasma membrane  integral component of plasma membrane  receptor-mediated endocytosis  chemotaxis  inflammatory response  immune response  G-protein coupled receptor signaling pathway  multicellular organism development  C-C chemokine binding  nuclear membrane  intracellular membrane-bounded organelle  recycling endosome  chemokine-mediated signaling pathway  
NDEx NetworkACKR2
Atlas of Cancer Signalling NetworkACKR2
Wikipedia pathwaysACKR2
Orthology - Evolution
OrthoDB1238
GeneTree (enSembl)ENSG00000144648
Phylogenetic Trees/Animal Genes : TreeFamACKR2
HOVERGENO00590
HOGENOMO00590
Homologs : HomoloGeneACKR2
Homology/Alignments : Family Browser (UCSC)ACKR2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACKR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACKR2
dbVarACKR2
ClinVarACKR2
1000_GenomesACKR2 
Exome Variant ServerACKR2
ExAC (Exome Aggregation Consortium)ACKR2 (select the gene name)
Genetic variants : HAPMAP1238
Genomic Variants (DGV)ACKR2 [DGVbeta]
DECIPHERACKR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACKR2 
Mutations
ICGC Data PortalACKR2 
TCGA Data PortalACKR2 
Broad Tumor PortalACKR2
OASIS PortalACKR2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDACKR2
BioMutasearch ACKR2
DgiDB (Drug Gene Interaction Database)ACKR2
DoCM (Curated mutations)ACKR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACKR2 (select a term)
intoGenACKR2
Cancer3DACKR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602648   
Orphanet
MedgenACKR2
Genetic Testing Registry ACKR2
NextProtO00590 [Medical]
TSGene1238
GENETestsACKR2
Target ValidationACKR2
Huge Navigator ACKR2 [HugePedia]
snp3D : Map Gene to Disease1238
BioCentury BCIQACKR2
ClinGenACKR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1238
Chemical/Pharm GKB GenePA26139
Clinical trialACKR2
Miscellaneous
canSAR (ICR)ACKR2 (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACKR2
EVEXACKR2
GoPubMedACKR2
iHOPACKR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:22:30 CEST 2017

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