ACO1 (aconitase 1, soluble)

Identity

Other names	ACONS
	IREB1
	IREBP
	IREBP1
	IRP1
HGNC	ACO1
Location	9p21.1
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

External links

	Nomenclature
HGNC	ACO1   117
Entrez_Gene	ACO1  48  aconitase 1, soluble
	Cards
GeneCards	ACO1
Ensembl	ACO1 [Search_View]   ENSG00000122729 [Gene_View]
Genatlas	ACO1
GeneLynx	ACO1
eGenome	ACO1
euGene	48
	Genomic and cartography
GoldenPath	ACO1  -  9p21.1   chr9:32374601-32440832 +  9p21.1   [Description]    (hg18-March_2006)
Ensembl	ACO1 - 9p21.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ACO1
	Gene and transcription
Genbank	AB209480 [ ENTREZ ]
Genbank	AF261088 [ ENTREZ ]
Genbank	AK057904 [ ENTREZ ]
Genbank	AK308752 [ ENTREZ ]
Genbank	BC018103 [ ENTREZ ]
RefSeq	NM_002197 [ SRS ]    NM_002197 [ ENTREZ ]
RefSeq	AC_000052 [ SRS ]    AC_000052 [ ENTREZ ]
RefSeq	AC_000141 [ SRS ]    AC_000141 [ ENTREZ ]
RefSeq	NC_000009 [ SRS ]    NC_000009 [ ENTREZ ]
RefSeq	NT_008413 [ SRS ]    NT_008413 [ ENTREZ ]
RefSeq	NW_001839149 [ SRS ]    NW_001839149 [ ENTREZ ]
RefSeq	NW_924062 [ SRS ]    NW_924062 [ ENTREZ ]
AceView	ACO1 AceView - NCBI
Unigene	Hs.709222 [ SRS ]    Hs.709222 [ NCBI ]     HS709222 [ spliceNest ]
Fast-db	3914 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P21399 [ SRS]    P21399 [ EXPASY ]     P21399 [ INTERPRO ]     P21399 [ UNIPROT ]
Prosite	PS00450 ACONITASE_1 [ SRS ]    PS00450 ACONITASE_1 [ Expasy ]
Prosite	PS01244 ACONITASE_2 [ SRS ]    PS01244 ACONITASE_2 [ Expasy ]
Interpro	IPR015931 Acnase/IPM_dHydase_lsu_aba_1/3 [ SRS ]    IPR015931 Acnase/IPM_dHydase_lsu_aba_1/3 [ EBI ]
Interpro	IPR001030 Acoase/IPM_deHydtase_lsu_aba [ SRS ]    IPR001030 Acoase/IPM_deHydtase_lsu_aba [ EBI ]
Interpro	IPR015937 Aconitase-like_core [ SRS ]    IPR015937 Aconitase-like_core [ EBI ]
Interpro	IPR015928 Aconitase/3IPM_dehydase_swvl [ SRS ]    IPR015928 Aconitase/3IPM_dehydase_swvl [ EBI ]
Interpro	IPR006249 Aconitase/Fe_reg_prot_2 [ SRS ]    IPR006249 Aconitase/Fe_reg_prot_2 [ EBI ]
Interpro	IPR015934 Aconitase/Fe_reg_prot_2/AcnD [ SRS ]    IPR015934 Aconitase/Fe_reg_prot_2/AcnD [ EBI ]
Interpro	IPR015932 Aconitase/IPMdHydase_lsu_aba_2 [ SRS ]    IPR015932 Aconitase/IPMdHydase_lsu_aba_2 [ EBI ]
Interpro	IPR000573 AconitaseA/IPMdHydase_ssu_swvl [ SRS ]    IPR000573 AconitaseA/IPMdHydase_ssu_swvl [ EBI ]
CluSTr	P21399
Pfam	PF00330 Aconitase [ SRS ]    PF00330 Aconitase [ Sanger ]    pfam00330 [ NCBI-CDD ]
Pfam	PF00694 Aconitase_C [ SRS ]    PF00694 Aconitase_C [ Sanger ]    pfam00694 [ NCBI-CDD ]
Prodom	PD000511 Aconitase_N[INRA-Toulouse]
Prodom	P21399 ACOC_HUMAN [ Domain structure ]   P21399 ACOC_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P21399
PDB	2B3X [ SRS ]    2B3X [ PdbSum ],   2B3X [ IMB ]   2B3X [ RSDB ]
PDB	2B3Y [ SRS ]    2B3Y [ PdbSum ],   2B3Y [ IMB ]   2B3Y [ RSDB ]
HPRD	00013
	Protein Interaction databases
DIP	P21399
IntAct	P21399
	Polymorphism : SNP, mutations, diseases
OMIM	100880    [ map ]
GENECLINICS	100880
SNP	ACO1 [dbSNP-NCBI]
SNP	NM_002197 [SNP-NCI]
SNP	ACO1 [GeneSNPs - Utah]  ACO1] [HGBASE - SRS]
HAPMAP	ACO1 [HAPMAP]
COSMIC	ACO1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ACO1
	General knowledge
Family Browser	ACO1 [UCSC Family Browser]
SOURCE	NM_002197
SMD	Hs.709222
SAGE	Hs.709222
Enzyme	4.2.1.3 [ Enzyme-Expasy ]   4.2.1.3 [ Enzyme-SRS ]   4.2.1.3 [ IntEnz-EBI ]   4.2.1.3 [ BRENDA ]   4.2.1.3 [ KEGG ]   4.2.1.3 [ WIT ]
GO	RNA binding [Amigo]  RNA binding
GO	RNA binding [Amigo]  RNA binding
GO	aconitate hydratase activity [Amigo]  aconitate hydratase activity
GO	iron ion binding [Amigo]  iron ion binding
GO	cytoplasm [Amigo]  cytoplasm
GO	endoplasmic reticulum [Amigo]  endoplasmic reticulum
GO	Golgi apparatus [Amigo]  Golgi apparatus
GO	cytosol [Amigo]  cytosol
GO	tricarboxylic acid cycle [Amigo]  tricarboxylic acid cycle
GO	citrate metabolic process [Amigo]  citrate metabolic process
GO	metabolic process [Amigo]  metabolic process
GO	lyase activity [Amigo]  lyase activity
GO	metal ion binding [Amigo]  metal ion binding
GO	4 iron, 4 sulfur cluster binding [Amigo]  4 iron, 4 sulfur cluster binding
KEGG	Citrate cycle (TCA cycle)
KEGG	Glyoxylate and dicarboxylate metabolism
KEGG	Reductive carboxylate cycle (CO2 fixation)
PubGene	ACO1
TreeFam	ACO1
CTD	48 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ACO1 Related clones (RZPD - Berlin)
	PubMed
PubMed	35 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 19:58:39 2008