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ACO1 (aconitase 1, soluble)

Identity

Other namesACONS
IREB1
IREBP
IREBP1
IRP1
HGNC (Hugo) ACO1
LocusID (NCBI) 48
Location 9p21.1
Location_base_pair Starts at 32384601 and ends at 32450832 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ACO1   117
Entrez_Gene (NCBI)ACO1  48  aconitase 1, soluble
Cards
GeneCards (Weizmann)ACO1
Ensembl (Hinxton)ENSG00000122729 [Gene_View]  chr9:32384601-32450832 [Contig_View]  ACO1 [Vega]
AceView (NCBI)ACO1
Genatlas (Paris)ACO1
SOURCE (Stanford)NM_002197
Genomic and cartography
GoldenPath (UCSC)ACO1  -  9p21.1   chr9:32384601-32450832 +  9p21.1   [Description]    (hg19-Feb_2009)
EnsemblACO1 - 9p21.1 [CytoView]
Mapping of homologs : NCBIACO1 [Mapview]
OMIM100880   
Gene and transcription
Genbank (Entrez)AB209480 AF261088 AK057904 AK308752 BC018103
RefSeq transcript (SRS)NM_002197
RefSeq transcript (Entrez)NM_002197
RefSeq genomic (SRS)AC_000141 NC_000009 NC_018920 NT_008413 NW_001839149 NW_004078038
RefSeq genomic (Entrez)AC_000141 NC_000009 NC_018920 NT_008413 NW_001839149 NW_004078038
Consensus coding sequences : CCDS (NCBI)ACO1
Cluster EST : UnigeneHs.567229 [ SRS ] Hs.567229 [ NCBI ]
CGAP (NCI)Hs.567229
Alternative Splicing : Fast-db (Paris)GSHG0030060
Alternative Splicing GalleryENSG00000122729
Gene ExpressionACO1 [ NCBI-GEO ]   ACO1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21399 (SRS) P21399 (Uniprot)
NextProtP21399
With graphics : InterProP21399
Splice isoforms : SwissVarP21399(Swissvar)
Domaine pattern : Prosite (SRS)ACONITASE_1 (PS00450)    ACONITASE_2 (PS01244)   
Domaine pattern : Prosite (Expaxy)ACONITASE_1 (PS00450)    ACONITASE_2 (PS01244)   
Domains : Interpro (SRS)Acnase/IPM_dHydase_lsu_aba_1/3    Acoase/IPM_deHydtase    Acoase/IPM_deHydtase_lsu_aba    Aconitase/3IPM_dehydase_swvl    Aconitase/Fe_reg_prot_2    Aconitase/Fe_reg_prot_2/AcnD    Aconitase/IPMdHydase_lsu_aba_2    Aconitase_4Fe-4S_BS    AconitaseA/IPMdHydase_ssu_swvl   
Domains : Interpro (EBI)Acnase/IPM_dHydase_lsu_aba_1/3    Acoase/IPM_deHydtase    Acoase/IPM_deHydtase_lsu_aba    Aconitase/3IPM_dehydase_swvl    Aconitase/Fe_reg_prot_2    Aconitase/Fe_reg_prot_2/AcnD    Aconitase/IPMdHydase_lsu_aba_2    Aconitase_4Fe-4S_BS    AconitaseA/IPMdHydase_ssu_swvl   
Related proteins : CluSTrP21399
Domain families : Pfam (SRS)Aconitase (PF00330)    Aconitase_C (PF00694)   
Domain families : Pfam (Sanger)Aconitase (PF00330)    Aconitase_C (PF00694)   
Domain families : Pfam (NCBI)pfam00330    pfam00694   
DMDM48
Blocks (Seattle)P21399
PDB (SRS)2B3X    2B3Y   
PDB (PDBSum)2B3X    2B3Y   
PDB (IMB)2B3X    2B3Y   
PDB (RSDB)2B3X    2B3Y   
Human Protein AtlasENSG00000122729
HPRD00013
IPIIPI00008485   IPI00930318   IPI01011965   IPI00643595   
Protein Interaction databases
DIP (DOE-UCLA)P21399
IntAct (EBI)P21399
FunCoupENSG00000122729
REACTOMEACO1
Protein Interaction Database48
BioGRIDACO1
InParanoidP21399
Interologous Interaction database P21399
IntegromeDBACO1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ACO1
SNP (GeneSNP Utah)ACO1
SNP : HGBaseACO1
Genetic variants : HAPMAPACO1
Somatic Mutations in Cancer : COSMICACO1 
CONAN: Copy Number AnalysisACO1 
Mutations and Diseases : HGMDACO1
OMIM100880   
GENETests100880   
Disease Genetic AssociationACO1
Huge Navigator ACO1 [HugePedia]  ACO1 [HugeCancerGEM]
Genomic VariantsACO1  ACO1 [DGVbeta]
snp3D : Map Gene to Disease48
General knowledge
Homologs : HomoloGeneACO1
Homology/Alignments : Family Browser (UCSC)ACO1
Phylogenetic Trees/Animal Genes : TreeFamACO1
Catalytic activity : Enzyme4.2.1.3 [ Enzyme-Expasy ]   4.2.1.3 [ Enzyme-SRS ]   4.2.1.3 [ IntEnz-EBI ]   4.2.1.3 [ BRENDA ]   4.2.1.3 [ KEGG ]   
Chemical/Protein Interactions : CTD48
Chemical/Pharm GKB GenePA24442
Clinical trialACO1
Cancer Resource (Charite)ENSG00000122729
Ontology : AmiGORNA binding  RNA binding  aconitate hydratase activity  protein binding  cytoplasm  cytoplasm  mitochondrion  endoplasmic reticulum  Golgi apparatus  cytosol  tricarboxylic acid cycle  citrate metabolic process  regulation of translation  cellular iron ion homeostasis  post-embryonic development  response to iron(II) ion  iron-responsive element binding  metal ion binding  mRNA 5'-UTR binding  intestinal absorption  4 iron, 4 sulfur cluster binding  citrate hydro-lyase (cis-aconitate-forming) activity  isocitrate hydro-lyase (cis-aconitate-forming) activity  
Ontology : EGO-EBIRNA binding  RNA binding  aconitate hydratase activity  protein binding  cytoplasm  cytoplasm  mitochondrion  endoplasmic reticulum  Golgi apparatus  cytosol  tricarboxylic acid cycle  citrate metabolic process  regulation of translation  cellular iron ion homeostasis  post-embryonic development  response to iron(II) ion  iron-responsive element binding  metal ion binding  mRNA 5'-UTR binding  intestinal absorption  4 iron, 4 sulfur cluster binding  citrate hydro-lyase (cis-aconitate-forming) activity  isocitrate hydro-lyase (cis-aconitate-forming) activity  
Pathways : KEGGCitrate cycle (TCA cycle)Reductive carboxylate cycle (CO2 fixation)Glyoxylate and dicarboxylate metabolism
Other databases
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
PubGeneACO1
iHOPACO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:29:25 CEST 2013
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