Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ACOT1 (acyl-CoA thioesterase 1)

Identity

Alias_symbol (synonym)ACH2
CTE-1
LACH2
Other alias
HGNC (Hugo) ACOT1
LocusID (NCBI) 641371
Atlas_Id 60086
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 73537224 and ends at 73543794 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACOT1 (14q24.3) / OAS3 (12q24.13)ELMSAN1 (14q24.3) / ACOT1 (14q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACOT1   33128
Cards
Entrez_Gene (NCBI)ACOT1  641371  acyl-CoA thioesterase 1
AliasesACH2; CTE-1; LACH2
GeneCards (Weizmann)ACOT1
Ensembl hg19 (Hinxton)ENSG00000184227 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184227 [Gene_View]  chr14:73537224-73543794 [Contig_View]  ACOT1 [Vega]
ICGC DataPortalENSG00000184227
TCGA cBioPortalACOT1
AceView (NCBI)ACOT1
Genatlas (Paris)ACOT1
WikiGenes641371
SOURCE (Princeton)ACOT1
Genetics Home Reference (NIH)ACOT1
Genomic and cartography
GoldenPath hg38 (UCSC)ACOT1  -     chr14:73537224-73543794 +  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACOT1  -     14q24.3   [Description]    (hg19-Feb_2009)
EnsemblACOT1 - 14q24.3 [CytoView hg19]  ACOT1 - 14q24.3 [CytoView hg38]
Mapping of homologs : NCBIACOT1 [Mapview hg19]  ACOT1 [Mapview hg38]
OMIM614313   
Gene and transcription
Genbank (Entrez)AK300886 BC127747 BC127748 BC132889 BC132891
RefSeq transcript (Entrez)NM_001037161
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACOT1
Cluster EST : UnigeneHs.568046 [ NCBI ]
CGAP (NCI)Hs.568046
Alternative Splicing GalleryENSG00000184227
Gene ExpressionACOT1 [ NCBI-GEO ]   ACOT1 [ EBI - ARRAY_EXPRESS ]   ACOT1 [ SEEK ]   ACOT1 [ MEM ]
Gene Expression Viewer (FireBrowse)ACOT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)641371
GTEX Portal (Tissue expression)ACOT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86TX2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86TX2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86TX2
Splice isoforms : SwissVarQ86TX2
Catalytic activity : Enzyme3.1.2.2 [ Enzyme-Expasy ]   3.1.2.23.1.2.2 [ IntEnz-EBI ]   3.1.2.2 [ BRENDA ]   3.1.2.2 [ KEGG ]   
PhosPhoSitePlusQ86TX2
Domains : Interpro (EBI)AB_hydrolase    Acyl-CoA_thioEstase_long-chain    BAAT_C    Thio_Ohase/aa_AcTrfase   
Domain families : Pfam (Sanger)BAAT_C (PF08840)    Bile_Hydr_Trans (PF04775)   
Domain families : Pfam (NCBI)pfam08840    pfam04775   
Conserved Domain (NCBI)ACOT1
DMDM Disease mutations641371
Blocks (Seattle)ACOT1
SuperfamilyQ86TX2
Human Protein AtlasENSG00000184227
Peptide AtlasQ86TX2
IPIIPI00333838   IPI00922628   
Protein Interaction databases
DIP (DOE-UCLA)Q86TX2
IntAct (EBI)Q86TX2
FunCoupENSG00000184227
BioGRIDACOT1
STRING (EMBL)ACOT1
ZODIACACOT1
Ontologies - Pathways
QuickGOQ86TX2
Ontology : AmiGOvery long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  cytosol  cytosol  acyl-CoA metabolic process  palmitoyl-CoA hydrolase activity  long-chain fatty-acyl-CoA biosynthetic process  acyl-CoA hydrolase activity  acyl-CoA hydrolase activity  carboxylic ester hydrolase activity  myristoyl-CoA hydrolase activity  
Ontology : EGO-EBIvery long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  cytosol  cytosol  acyl-CoA metabolic process  palmitoyl-CoA hydrolase activity  long-chain fatty-acyl-CoA biosynthetic process  acyl-CoA hydrolase activity  acyl-CoA hydrolase activity  carboxylic ester hydrolase activity  myristoyl-CoA hydrolase activity  
Pathways : KEGGFatty acid elongation    Biosynthesis of unsaturated fatty acids   
NDEx NetworkACOT1
Atlas of Cancer Signalling NetworkACOT1
Wikipedia pathwaysACOT1
Orthology - Evolution
OrthoDB641371
GeneTree (enSembl)ENSG00000184227
Phylogenetic Trees/Animal Genes : TreeFamACOT1
HOVERGENQ86TX2
HOGENOMQ86TX2
Homologs : HomoloGeneACOT1
Homology/Alignments : Family Browser (UCSC)ACOT1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACOT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACOT1
dbVarACOT1
ClinVarACOT1
1000_GenomesACOT1 
Exome Variant ServerACOT1
ExAC (Exome Aggregation Consortium)ACOT1 (select the gene name)
Genetic variants : HAPMAP641371
Genomic Variants (DGV)ACOT1 [DGVbeta]
DECIPHERACOT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACOT1 
Mutations
ICGC Data PortalACOT1 
TCGA Data PortalACOT1 
Broad Tumor PortalACOT1
OASIS PortalACOT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACOT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACOT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ACOT1
DgiDB (Drug Gene Interaction Database)ACOT1
DoCM (Curated mutations)ACOT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACOT1 (select a term)
intoGenACOT1
Cancer3DACOT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614313   
Orphanet
MedgenACOT1
Genetic Testing Registry ACOT1
NextProtQ86TX2 [Medical]
TSGene641371
GENETestsACOT1
Target ValidationACOT1
Huge Navigator ACOT1 [HugePedia]
snp3D : Map Gene to Disease641371
BioCentury BCIQACOT1
ClinGenACOT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD641371
Chemical/Pharm GKB GenePA162375318
Clinical trialACOT1
Miscellaneous
canSAR (ICR)ACOT1 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACOT1
EVEXACOT1
GoPubMedACOT1
iHOPACOT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:37:14 CEST 2017

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