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ACOT12 (acyl-CoA thioesterase 12)

Identity

Alias (NCBI)CACH-1
Cach
STARD15
THEAL
HGNC (Hugo) ACOT12
HGNC Alias symbCach
THEAL
STARD15
HGNC Alias nameStAR-related lipid transfer (START) domain containing 15
LocusID (NCBI) 134526
Atlas_Id 60088
Location 5q14.1  [Link to chromosome band 5q14]
Location_base_pair Starts at 81329996 and ends at 81394134 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IQGAP2 (5q13.3) / ACOT12 (5q14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ACOT12   24436
Cards
Entrez_Gene (NCBI)ACOT12    acyl-CoA thioesterase 12
AliasesCACH-1; Cach; STARD15; THEAL
GeneCards (Weizmann)ACOT12
Ensembl hg19 (Hinxton)ENSG00000172497 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172497 [Gene_View]  ENSG00000172497 [Sequence]  chr5:81329996-81394134 [Contig_View]  ACOT12 [Vega]
ICGC DataPortalENSG00000172497
TCGA cBioPortalACOT12
AceView (NCBI)ACOT12
Genatlas (Paris)ACOT12
SOURCE (Princeton)ACOT12
Genetics Home Reference (NIH)ACOT12
Genomic and cartography
GoldenPath hg38 (UCSC)ACOT12  -     chr5:81329996-81394134 -  5q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACOT12  -     5q14.1   [Description]    (hg19-Feb_2009)
GoldenPathACOT12 - 5q14.1 [CytoView hg19]  ACOT12 - 5q14.1 [CytoView hg38]
ImmunoBaseENSG00000172497
Genome Data Viewer NCBIACOT12 [Mapview hg19]  
OMIM614315   
Gene and transcription
Genbank (Entrez)AB078619 AK122960 BC075010 BC075011 BC089437
RefSeq transcript (Entrez)NM_130767
Consensus coding sequences : CCDS (NCBI)ACOT12
Gene ExpressionACOT12 [ NCBI-GEO ]   ACOT12 [ EBI - ARRAY_EXPRESS ]   ACOT12 [ SEEK ]   ACOT12 [ MEM ]
Gene Expression Viewer (FireBrowse)ACOT12 [ Firebrowse - Broad ]
GenevisibleExpression of ACOT12 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)134526
GTEX Portal (Tissue expression)ACOT12
Human Protein AtlasENSG00000172497-ACOT12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WYK0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WYK0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WYK0
PhosPhoSitePlusQ8WYK0
Domaine pattern : Prosite (Expaxy)HOTDOG_ACOT (PS51770)    START (PS50848)   
Domains : Interpro (EBI)Cytosol_ACT    HOTDOG_ACOT    HotDog_dom_sf    START-like_dom_sf    START_lipid-bd_dom    Thioestr_dom   
Domain families : Pfam (Sanger)4HBT (PF03061)    START (PF01852)   
Domain families : Pfam (NCBI)pfam03061    pfam01852   
Conserved Domain (NCBI)ACOT12
PDB (RSDB)3B7K    4MOB    4MOC   
PDB Europe3B7K    4MOB    4MOC   
PDB (PDBSum)3B7K    4MOB    4MOC   
PDB (IMB)3B7K    4MOB    4MOC   
Structural Biology KnowledgeBase3B7K    4MOB    4MOC   
SCOP (Structural Classification of Proteins)3B7K    4MOB    4MOC   
CATH (Classification of proteins structures)3B7K    4MOB    4MOC   
SuperfamilyQ8WYK0
AlphaFold pdb e-kbQ8WYK0   
Human Protein Atlas [tissue]ENSG00000172497-ACOT12 [tissue]
HPRD16680
Protein Interaction databases
DIP (DOE-UCLA)Q8WYK0
IntAct (EBI)Q8WYK0
BioGRIDACOT12
STRING (EMBL)ACOT12
ZODIACACOT12
Ontologies - Pathways
QuickGOQ8WYK0
Ontology : AmiGOacetyl-CoA hydrolase activity  acetyl-CoA hydrolase activity  protein binding  ATP binding  cytosol  cytosol  cytosol  acetyl-CoA metabolic process  fatty acid metabolic process  fatty acid metabolic process  acyl-CoA metabolic process  acyl-CoA metabolic process  acyl-CoA metabolic process  lipid binding  long-chain fatty acyl-CoA binding  identical protein binding  acyl-CoA hydrolase activity  carboxylic ester hydrolase activity  
Ontology : EGO-EBIacetyl-CoA hydrolase activity  acetyl-CoA hydrolase activity  protein binding  ATP binding  cytosol  cytosol  cytosol  acetyl-CoA metabolic process  fatty acid metabolic process  fatty acid metabolic process  acyl-CoA metabolic process  acyl-CoA metabolic process  acyl-CoA metabolic process  lipid binding  long-chain fatty acyl-CoA binding  identical protein binding  acyl-CoA hydrolase activity  carboxylic ester hydrolase activity  
Pathways : KEGGPyruvate metabolism   
NDEx NetworkACOT12
Atlas of Cancer Signalling NetworkACOT12
Wikipedia pathwaysACOT12
Orthology - Evolution
OrthoDB134526
GeneTree (enSembl)ENSG00000172497
Phylogenetic Trees/Animal Genes : TreeFamACOT12
Homologs : HomoloGeneACOT12
Homology/Alignments : Family Browser (UCSC)ACOT12
Gene fusions - Rearrangements
Fusion : QuiverACOT12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACOT12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACOT12
dbVarACOT12
ClinVarACOT12
MonarchACOT12
1000_GenomesACOT12 
Exome Variant ServerACOT12
GNOMAD BrowserENSG00000172497
Varsome BrowserACOT12
ACMGACOT12 variants
VarityQ8WYK0
Genomic Variants (DGV)ACOT12 [DGVbeta]
DECIPHERACOT12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACOT12 
Mutations
ICGC Data PortalACOT12 
TCGA Data PortalACOT12 
Broad Tumor PortalACOT12
OASIS PortalACOT12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACOT12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DACOT12
Mutations and Diseases : HGMDACOT12
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaACOT12
DgiDB (Drug Gene Interaction Database)ACOT12
DoCM (Curated mutations)ACOT12
CIViC (Clinical Interpretations of Variants in Cancer)ACOT12
Cancer3DACOT12
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614315   
Orphanet
DisGeNETACOT12
MedgenACOT12
Genetic Testing Registry ACOT12
NextProtQ8WYK0 [Medical]
GENETestsACOT12
Target ValidationACOT12
Huge Navigator ACOT12 [HugePedia]
ClinGenACOT12
Clinical trials, drugs, therapy
MyCancerGenomeACOT12
Protein Interactions : CTDACOT12
Pharm GKB GenePA142672657
PharosQ8WYK0
Clinical trialACOT12
Miscellaneous
canSAR (ICR)ACOT12
HarmonizomeACOT12
DataMed IndexACOT12
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXACOT12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:41:22 CEST 2021

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