Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ACOT12 (acyl-CoA thioesterase 12)

Identity

Alias_symbol (synonym)Cach
THEAL
STARD15
Other aliasCACH-1
HGNC (Hugo) ACOT12
LocusID (NCBI) 134526
Atlas_Id 60088
Location 5q14.1  [Link to chromosome band 5q14]
Location_base_pair Starts at 80625947 and ends at 80689988 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IQGAP2 (5q13.3) / ACOT12 (5q14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACOT12   24436
Cards
Entrez_Gene (NCBI)ACOT12  134526  acyl-CoA thioesterase 12
AliasesCACH-1; Cach; STARD15; THEAL
GeneCards (Weizmann)ACOT12
Ensembl hg19 (Hinxton)ENSG00000172497 [Gene_View]  chr5:80625947-80689988 [Contig_View]  ACOT12 [Vega]
Ensembl hg38 (Hinxton)ENSG00000172497 [Gene_View]  chr5:80625947-80689988 [Contig_View]  ACOT12 [Vega]
ICGC DataPortalENSG00000172497
TCGA cBioPortalACOT12
AceView (NCBI)ACOT12
Genatlas (Paris)ACOT12
WikiGenes134526
SOURCE (Princeton)ACOT12
Genetics Home Reference (NIH)ACOT12
Genomic and cartography
GoldenPath hg19 (UCSC)ACOT12  -     chr5:80625947-80689988 -  5q14.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ACOT12  -     5q14.1   [Description]    (hg38-Dec_2013)
EnsemblACOT12 - 5q14.1 [CytoView hg19]  ACOT12 - 5q14.1 [CytoView hg38]
Mapping of homologs : NCBIACOT12 [Mapview hg19]  ACOT12 [Mapview hg38]
OMIM614315   
Gene and transcription
Genbank (Entrez)AB078619 AK122960 BC075010 BC075011 BC089437
RefSeq transcript (Entrez)NM_130767
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_034772 NW_004929322
Consensus coding sequences : CCDS (NCBI)ACOT12
Cluster EST : UnigeneHs.591756 [ NCBI ]
CGAP (NCI)Hs.591756
Alternative Splicing GalleryENSG00000172497
Gene ExpressionACOT12 [ NCBI-GEO ]   ACOT12 [ EBI - ARRAY_EXPRESS ]   ACOT12 [ SEEK ]   ACOT12 [ MEM ]
Gene Expression Viewer (FireBrowse)ACOT12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)134526
GTEX Portal (Tissue expression)ACOT12
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WYK0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WYK0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WYK0
Splice isoforms : SwissVarQ8WYK0
Catalytic activity : Enzyme3.1.2.1 [ Enzyme-Expasy ]   3.1.2.13.1.2.1 [ IntEnz-EBI ]   3.1.2.1 [ BRENDA ]   3.1.2.1 [ KEGG ]   
PhosPhoSitePlusQ8WYK0
Domaine pattern : Prosite (Expaxy)START (PS50848)   
Domains : Interpro (EBI)HotDog_dom    START-like_dom    START_lipid-bd_dom    Thioestr_supf   
Domain families : Pfam (Sanger)4HBT (PF03061)    START (PF01852)   
Domain families : Pfam (NCBI)pfam03061    pfam01852   
Conserved Domain (NCBI)ACOT12
DMDM Disease mutations134526
Blocks (Seattle)ACOT12
PDB (SRS)3B7K    4MOB    4MOC   
PDB (PDBSum)3B7K    4MOB    4MOC   
PDB (IMB)3B7K    4MOB    4MOC   
PDB (RSDB)3B7K    4MOB    4MOC   
Structural Biology KnowledgeBase3B7K    4MOB    4MOC   
SCOP (Structural Classification of Proteins)3B7K    4MOB    4MOC   
CATH (Classification of proteins structures)3B7K    4MOB    4MOC   
SuperfamilyQ8WYK0
Human Protein AtlasENSG00000172497
Peptide AtlasQ8WYK0
HPRD16680
IPIIPI00103729   IPI00967466   
Protein Interaction databases
DIP (DOE-UCLA)Q8WYK0
IntAct (EBI)Q8WYK0
FunCoupENSG00000172497
BioGRIDACOT12
STRING (EMBL)ACOT12
ZODIACACOT12
Ontologies - Pathways
QuickGOQ8WYK0
Ontology : AmiGOacetyl-CoA hydrolase activity  ATP binding  cytosol  acetyl-CoA metabolic process  pyruvate metabolic process  fatty acid metabolic process  acyl-CoA metabolic process  lipid binding  carboxylic ester hydrolase activity  
Ontology : EGO-EBIacetyl-CoA hydrolase activity  ATP binding  cytosol  acetyl-CoA metabolic process  pyruvate metabolic process  fatty acid metabolic process  acyl-CoA metabolic process  lipid binding  carboxylic ester hydrolase activity  
Pathways : KEGGPyruvate metabolism   
NDEx NetworkACOT12
Atlas of Cancer Signalling NetworkACOT12
Wikipedia pathwaysACOT12
Orthology - Evolution
OrthoDB134526
GeneTree (enSembl)ENSG00000172497
Phylogenetic Trees/Animal Genes : TreeFamACOT12
HOVERGENQ8WYK0
HOGENOMQ8WYK0
Homologs : HomoloGeneACOT12
Homology/Alignments : Family Browser (UCSC)ACOT12
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACOT12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACOT12
dbVarACOT12
ClinVarACOT12
1000_GenomesACOT12 
Exome Variant ServerACOT12
ExAC (Exome Aggregation Consortium)ACOT12 (select the gene name)
Genetic variants : HAPMAP134526
Genomic Variants (DGV)ACOT12 [DGVbeta]
DECIPHER (Syndromes)5:80625947-80689988  ENSG00000172497
CONAN: Copy Number AnalysisACOT12 
Mutations
ICGC Data PortalACOT12 
TCGA Data PortalACOT12 
Broad Tumor PortalACOT12
OASIS PortalACOT12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACOT12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACOT12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ACOT12
DgiDB (Drug Gene Interaction Database)ACOT12
DoCM (Curated mutations)ACOT12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACOT12 (select a term)
intoGenACOT12
Cancer3DACOT12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614315   
Orphanet
MedgenACOT12
Genetic Testing Registry ACOT12
NextProtQ8WYK0 [Medical]
TSGene134526
GENETestsACOT12
Huge Navigator ACOT12 [HugePedia]
snp3D : Map Gene to Disease134526
BioCentury BCIQACOT12
ClinGenACOT12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD134526
Chemical/Pharm GKB GenePA142672657
Clinical trialACOT12
Miscellaneous
canSAR (ICR)ACOT12 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACOT12
EVEXACOT12
GoPubMedACOT12
iHOPACOT12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 11:53:29 CET 2017

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