Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ACOT2 (acyl-CoA thioesterase 2)

Identity

Alias_symbol (synonym)Mte1
ZAP128
Other aliasCTE-IA
CTE1A
MTE1
PTE2
PTE2A
HGNC (Hugo) ACOT2
LocusID (NCBI) 10965
Atlas_Id 60090
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 73569059 and ends at 73575658 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACOT2   18431
Cards
Entrez_Gene (NCBI)ACOT2  10965  acyl-CoA thioesterase 2
AliasesCTE-IA; CTE1A; MTE1; PTE2; 
PTE2A; ZAP128
GeneCards (Weizmann)ACOT2
Ensembl hg19 (Hinxton)ENSG00000119673 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119673 [Gene_View]  chr14:73569059-73575658 [Contig_View]  ACOT2 [Vega]
ICGC DataPortalENSG00000119673
TCGA cBioPortalACOT2
AceView (NCBI)ACOT2
Genatlas (Paris)ACOT2
WikiGenes10965
SOURCE (Princeton)ACOT2
Genetics Home Reference (NIH)ACOT2
Genomic and cartography
GoldenPath hg38 (UCSC)ACOT2  -     chr14:73569059-73575658 +  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACOT2  -     14q24.3   [Description]    (hg19-Feb_2009)
EnsemblACOT2 - 14q24.3 [CytoView hg19]  ACOT2 - 14q24.3 [CytoView hg38]
Mapping of homologs : NCBIACOT2 [Mapview hg19]  ACOT2 [Mapview hg38]
OMIM609972   
Gene and transcription
Genbank (Entrez)AI537078 AK001939 AK093131 AK223635 AY005822
RefSeq transcript (Entrez)NM_006821
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACOT2
Cluster EST : UnigeneHs.446685 [ NCBI ]
CGAP (NCI)Hs.446685
Alternative Splicing GalleryENSG00000119673
Gene ExpressionACOT2 [ NCBI-GEO ]   ACOT2 [ EBI - ARRAY_EXPRESS ]   ACOT2 [ SEEK ]   ACOT2 [ MEM ]
Gene Expression Viewer (FireBrowse)ACOT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10965
GTEX Portal (Tissue expression)ACOT2
Human Protein AtlasENSG00000119673-ACOT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49753   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49753  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49753
Splice isoforms : SwissVarP49753
PhosPhoSitePlusP49753
Domains : Interpro (EBI)AB_hydrolase    Acyl-CoA_thioEstase_long-chain    BAAT_C    Thio_Ohase/aa_AcTrfase   
Domain families : Pfam (Sanger)BAAT_C (PF08840)    Bile_Hydr_Trans (PF04775)   
Domain families : Pfam (NCBI)pfam08840    pfam04775   
Conserved Domain (NCBI)ACOT2
DMDM Disease mutations10965
Blocks (Seattle)ACOT2
PDB (SRS)3HLK   
PDB (PDBSum)3HLK   
PDB (IMB)3HLK   
PDB (RSDB)3HLK   
Structural Biology KnowledgeBase3HLK   
SCOP (Structural Classification of Proteins)3HLK   
CATH (Classification of proteins structures)3HLK   
SuperfamilyP49753
Human Protein Atlas [tissue]ENSG00000119673-ACOT2 [tissue]
Peptide AtlasP49753
HPRD10173
IPIIPI00220906   IPI00513928   IPI00930396   
Protein Interaction databases
DIP (DOE-UCLA)P49753
IntAct (EBI)P49753
FunCoupENSG00000119673
BioGRIDACOT2
STRING (EMBL)ACOT2
ZODIACACOT2
Ontologies - Pathways
QuickGOP49753
Ontology : AmiGOvery long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  receptor binding  mitochondrion  mitochondrial matrix  acyl-CoA metabolic process  palmitoyl-CoA hydrolase activity  long-chain fatty-acyl-CoA biosynthetic process  acyl-CoA hydrolase activity  acyl-CoA hydrolase activity  carboxylic ester hydrolase activity  extracellular exosome  myristoyl-CoA hydrolase activity  
Ontology : EGO-EBIvery long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  receptor binding  mitochondrion  mitochondrial matrix  acyl-CoA metabolic process  palmitoyl-CoA hydrolase activity  long-chain fatty-acyl-CoA biosynthetic process  acyl-CoA hydrolase activity  acyl-CoA hydrolase activity  carboxylic ester hydrolase activity  extracellular exosome  myristoyl-CoA hydrolase activity  
Pathways : KEGGFatty acid elongation    Biosynthesis of unsaturated fatty acids    Ovarian steroidogenesis   
NDEx NetworkACOT2
Atlas of Cancer Signalling NetworkACOT2
Wikipedia pathwaysACOT2
Orthology - Evolution
OrthoDB10965
GeneTree (enSembl)ENSG00000119673
Phylogenetic Trees/Animal Genes : TreeFamACOT2
HOVERGENP49753
HOGENOMP49753
Homologs : HomoloGeneACOT2
Homology/Alignments : Family Browser (UCSC)ACOT2
Gene fusions - Rearrangements
Tumor Fusion PortalACOT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACOT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACOT2
dbVarACOT2
ClinVarACOT2
1000_GenomesACOT2 
Exome Variant ServerACOT2
ExAC (Exome Aggregation Consortium)ENSG00000119673
GNOMAD BrowserENSG00000119673
Genetic variants : HAPMAP10965
Genomic Variants (DGV)ACOT2 [DGVbeta]
DECIPHERACOT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACOT2 
Mutations
ICGC Data PortalACOT2 
TCGA Data PortalACOT2 
Broad Tumor PortalACOT2
OASIS PortalACOT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACOT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACOT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ACOT2
DgiDB (Drug Gene Interaction Database)ACOT2
DoCM (Curated mutations)ACOT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACOT2 (select a term)
intoGenACOT2
Cancer3DACOT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609972   
Orphanet
DisGeNETACOT2
MedgenACOT2
Genetic Testing Registry ACOT2
NextProtP49753 [Medical]
TSGene10965
GENETestsACOT2
Target ValidationACOT2
Huge Navigator ACOT2 [HugePedia]
snp3D : Map Gene to Disease10965
BioCentury BCIQACOT2
ClinGenACOT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10965
Chemical/Pharm GKB GenePA142672653
Clinical trialACOT2
Miscellaneous
canSAR (ICR)ACOT2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACOT2
EVEXACOT2
GoPubMedACOT2
iHOPACOT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:29:09 CET 2017

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