Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ACOT4 (acyl-CoA thioesterase 4)

Identity

Alias (NCBI)PTE-Ib
PTE1B
PTE2B
HGNC (Hugo) ACOT4
HGNC Alias symbFLJ31235
PTE-Ib
PTE2B
LocusID (NCBI) 122970
Atlas_Id 60091
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 73591706 and ends at 73595766 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COQ6 (14q24.3) / ACOT4 (14q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  COQ6/ACOT4 (14q24)


External links

Nomenclature
HGNC (Hugo)ACOT4   19748
Cards
Entrez_Gene (NCBI)ACOT4  122970  acyl-CoA thioesterase 4
AliasesPTE-Ib; PTE1B; PTE2B
GeneCards (Weizmann)ACOT4
Ensembl hg19 (Hinxton)ENSG00000177465 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177465 [Gene_View]  ENSG00000177465 [Sequence]  chr14:73591706-73595766 [Contig_View]  ACOT4 [Vega]
ICGC DataPortalENSG00000177465
TCGA cBioPortalACOT4
AceView (NCBI)ACOT4
Genatlas (Paris)ACOT4
WikiGenes122970
SOURCE (Princeton)ACOT4
Genetics Home Reference (NIH)ACOT4
Genomic and cartography
GoldenPath hg38 (UCSC)ACOT4  -     chr14:73591706-73595766 +  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACOT4  -     14q24.3   [Description]    (hg19-Feb_2009)
GoldenPathACOT4 - 14q24.3 [CytoView hg19]  ACOT4 - 14q24.3 [CytoView hg38]
ImmunoBaseENSG00000177465
genome Data Viewer NCBIACOT4 [Mapview hg19]  
OMIM614314   
Gene and transcription
Genbank (Entrez)AK055797 AK094223 BC031799 BC090945 BC117341
RefSeq transcript (Entrez)NM_152331
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACOT4
Alternative Splicing GalleryENSG00000177465
Gene ExpressionACOT4 [ NCBI-GEO ]   ACOT4 [ EBI - ARRAY_EXPRESS ]   ACOT4 [ SEEK ]   ACOT4 [ MEM ]
Gene Expression Viewer (FireBrowse)ACOT4 [ Firebrowse - Broad ]
GenevisibleExpression of ACOT4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)122970
GTEX Portal (Tissue expression)ACOT4
Human Protein AtlasENSG00000177465-ACOT4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N9L9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N9L9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N9L9
Splice isoforms : SwissVarQ8N9L9
PhosPhoSitePlusQ8N9L9
Domains : Interpro (EBI)AB_hydrolase    Acyl-CoA_thioEstase_long-chain    BAAT_C    Thio_Ohase/aa_AcTrfase    Thio_Ohase/BAAT_N   
Domain families : Pfam (Sanger)BAAT_C (PF08840)    Bile_Hydr_Trans (PF04775)   
Domain families : Pfam (NCBI)pfam08840    pfam04775   
Conserved Domain (NCBI)ACOT4
DMDM Disease mutations122970
Blocks (Seattle)ACOT4
PDB (RSDB)3K2I   
PDB Europe3K2I   
PDB (PDBSum)3K2I   
PDB (IMB)3K2I   
Structural Biology KnowledgeBase3K2I   
SCOP (Structural Classification of Proteins)3K2I   
CATH (Classification of proteins structures)3K2I   
SuperfamilyQ8N9L9
Human Protein Atlas [tissue]ENSG00000177465-ACOT4 [tissue]
Peptide AtlasQ8N9L9
HPRD17928
IPIIPI00171211   
Protein Interaction databases
DIP (DOE-UCLA)Q8N9L9
IntAct (EBI)Q8N9L9
FunCoupENSG00000177465
BioGRIDACOT4
STRING (EMBL)ACOT4
ZODIACACOT4
Ontologies - Pathways
QuickGOQ8N9L9
Ontology : AmiGOvery long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  succinyl-CoA hydrolase activity  peroxisome  peroxisome  peroxisomal matrix  cytosol  succinyl-CoA metabolic process  protein targeting to peroxisome  fatty acid metabolic process  fatty acid biosynthetic process  acyl-CoA metabolic process  acyl-CoA metabolic process  acyl-CoA metabolic process  palmitoyl-CoA hydrolase activity  butyrate metabolic process  saturated monocarboxylic acid metabolic process  unsaturated monocarboxylic acid metabolic process  dicarboxylic acid metabolic process  dicarboxylic acid catabolic process  short-chain fatty acid metabolic process  acyl-CoA hydrolase activity  acyl-CoA hydrolase activity  carboxylic ester hydrolase activity  myristoyl-CoA hydrolase activity  
Ontology : EGO-EBIvery long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  succinyl-CoA hydrolase activity  peroxisome  peroxisome  peroxisomal matrix  cytosol  succinyl-CoA metabolic process  protein targeting to peroxisome  fatty acid metabolic process  fatty acid biosynthetic process  acyl-CoA metabolic process  acyl-CoA metabolic process  acyl-CoA metabolic process  palmitoyl-CoA hydrolase activity  butyrate metabolic process  saturated monocarboxylic acid metabolic process  unsaturated monocarboxylic acid metabolic process  dicarboxylic acid metabolic process  dicarboxylic acid catabolic process  short-chain fatty acid metabolic process  acyl-CoA hydrolase activity  acyl-CoA hydrolase activity  carboxylic ester hydrolase activity  myristoyl-CoA hydrolase activity  
NDEx NetworkACOT4
Atlas of Cancer Signalling NetworkACOT4
Wikipedia pathwaysACOT4
Orthology - Evolution
OrthoDB122970
GeneTree (enSembl)ENSG00000177465
Phylogenetic Trees/Animal Genes : TreeFamACOT4
HOGENOMQ8N9L9
Homologs : HomoloGeneACOT4
Homology/Alignments : Family Browser (UCSC)ACOT4
Gene fusions - Rearrangements
Fusion : QuiverACOT4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACOT4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACOT4
dbVarACOT4
ClinVarACOT4
1000_GenomesACOT4 
Exome Variant ServerACOT4
GNOMAD BrowserENSG00000177465
Varsome BrowserACOT4
Genetic variants : HAPMAP122970
Genomic Variants (DGV)ACOT4 [DGVbeta]
DECIPHERACOT4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACOT4 
Mutations
ICGC Data PortalACOT4 
TCGA Data PortalACOT4 
Broad Tumor PortalACOT4
OASIS PortalACOT4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACOT4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DACOT4
Mutations and Diseases : HGMDACOT4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ACOT4
DgiDB (Drug Gene Interaction Database)ACOT4
DoCM (Curated mutations)ACOT4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACOT4 (select a term)
intoGenACOT4
Cancer3DACOT4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614314   
Orphanet
DisGeNETACOT4
MedgenACOT4
Genetic Testing Registry ACOT4
NextProtQ8N9L9 [Medical]
TSGene122970
GENETestsACOT4
Target ValidationACOT4
Huge Navigator ACOT4 [HugePedia]
snp3D : Map Gene to Disease122970
BioCentury BCIQACOT4
ClinGenACOT4
Clinical trials, drugs, therapy
Protein Interactions : CTD122970
Pharm GKB GenePA142672654
Clinical trialACOT4
Miscellaneous
canSAR (ICR)ACOT4 (select the gene name)
HarmonizomeACOT4
DataMed IndexACOT4
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACOT4
EVEXACOT4
GoPubMedACOT4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Aug 22 19:05:03 CEST 2020

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.