Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ACOX1 (acyl-CoA oxidase 1, palmitoyl)

Identity

Alias_namesacyl-Coenzyme A oxidase 1, palmitoyl
acyl-CoA oxidase 1, palmitoyl
Alias_symbol (synonym)PALMCOX
Other aliasACOX
SCOX
HGNC (Hugo) ACOX1
LocusID (NCBI) 51
Atlas_Id 60093
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 73937589 and ends at 73975515 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACOX1 (17q25.1) / PRKAG2 (7q36.1)ACOX1 (17q25.1) / SRP68 (17q25.1)FAT3 (11q14.3) / ACOX1 (17q25.1)
GJA4 (1p34.3) / ACOX1 (17q25.1)TUG1 (22q12.2) / ACOX1 (17q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACOX1   119
Cards
Entrez_Gene (NCBI)ACOX1  51  acyl-CoA oxidase 1, palmitoyl
AliasesACOX; PALMCOX; SCOX
GeneCards (Weizmann)ACOX1
Ensembl hg19 (Hinxton)ENSG00000161533 [Gene_View]  chr17:73937589-73975515 [Contig_View]  ACOX1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000161533 [Gene_View]  chr17:73937589-73975515 [Contig_View]  ACOX1 [Vega]
ICGC DataPortalENSG00000161533
TCGA cBioPortalACOX1
AceView (NCBI)ACOX1
Genatlas (Paris)ACOX1
WikiGenes51
SOURCE (Princeton)ACOX1
Genetics Home Reference (NIH)ACOX1
Genomic and cartography
GoldenPath hg19 (UCSC)ACOX1  -     chr17:73937589-73975515 -  17q25.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ACOX1  -     17q25.1   [Description]    (hg38-Dec_2013)
EnsemblACOX1 - 17q25.1 [CytoView hg19]  ACOX1 - 17q25.1 [CytoView hg38]
Mapping of homologs : NCBIACOX1 [Mapview hg19]  ACOX1 [Mapview hg38]
OMIM264470   609751   
Gene and transcription
Genbank (Entrez)AK095501 AK225897 AK291793 AK292965 AK296409
RefSeq transcript (Entrez)NM_001185039 NM_004035 NM_007292
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_008190 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)ACOX1
Cluster EST : UnigeneHs.464137 [ NCBI ]
CGAP (NCI)Hs.464137
Alternative Splicing GalleryENSG00000161533
Gene ExpressionACOX1 [ NCBI-GEO ]   ACOX1 [ EBI - ARRAY_EXPRESS ]   ACOX1 [ SEEK ]   ACOX1 [ MEM ]
Gene Expression Viewer (FireBrowse)ACOX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51
GTEX Portal (Tissue expression)ACOX1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15067   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15067  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15067
Splice isoforms : SwissVarQ15067
Catalytic activity : Enzyme1.3.3.6 [ Enzyme-Expasy ]   1.3.3.61.3.3.6 [ IntEnz-EBI ]   1.3.3.6 [ BRENDA ]   1.3.3.6 [ KEGG ]   
PhosPhoSitePlusQ15067
Domains : Interpro (EBI)Acyl-CoA_ox_N    Acyl-CoA_Oxase/DH_cen-dom    Acyl-CoA_oxidase    Acyl-CoA_oxidase_C    AcylCo_DH/oxidase_C    AcylCoA_DH/ox_N    AcylCoA_DH/oxidase_NM_dom   
Domain families : Pfam (Sanger)ACOX (PF01756)    Acyl-CoA_dh_M (PF02770)    Acyl-CoA_ox_N (PF14749)   
Domain families : Pfam (NCBI)pfam01756    pfam02770    pfam14749   
Conserved Domain (NCBI)ACOX1
DMDM Disease mutations51
Blocks (Seattle)ACOX1
SuperfamilyQ15067
Human Protein AtlasENSG00000161533
Peptide AtlasQ15067
HPRD02030
IPIIPI00296907   IPI00477729   IPI01015174   IPI00984655   
Protein Interaction databases
DIP (DOE-UCLA)Q15067
IntAct (EBI)Q15067
FunCoupENSG00000161533
BioGRIDACOX1
STRING (EMBL)ACOX1
ZODIACACOX1
Ontologies - Pathways
QuickGOQ15067
Ontology : AmiGOvery long-chain fatty acid metabolic process  acyl-CoA dehydrogenase activity  acyl-CoA oxidase activity  acyl-CoA oxidase activity  acyl-CoA oxidase activity  acyl-CoA oxidase activity  receptor binding  fatty acid binding  nucleus  nucleoplasm  nucleolus  mitochondrion  peroxisome  peroxisomal membrane  peroxisomal matrix  plasma membrane  generation of precursor metabolites and energy  lipid metabolic process  prostaglandin metabolic process  spermatogenesis  membrane  palmitoyl-CoA oxidase activity  palmitoyl-CoA oxidase activity  peroxisome fission  fatty acid oxidation  fatty acid oxidation  PDZ domain binding  fatty acid beta-oxidation using acyl-CoA oxidase  fatty acid beta-oxidation using acyl-CoA oxidase  fatty acid beta-oxidation using acyl-CoA oxidase  unsaturated fatty acid metabolic process  alpha-linolenic acid metabolic process  intracellular membrane-bounded organelle  cellular lipid metabolic process  small molecule metabolic process  protein N-terminus binding  flavin adenine dinucleotide binding  lipid homeostasis  lipid homeostasis  FAD binding  positive regulation of cholesterol homeostasis  
Ontology : EGO-EBIvery long-chain fatty acid metabolic process  acyl-CoA dehydrogenase activity  acyl-CoA oxidase activity  acyl-CoA oxidase activity  acyl-CoA oxidase activity  acyl-CoA oxidase activity  receptor binding  fatty acid binding  nucleus  nucleoplasm  nucleolus  mitochondrion  peroxisome  peroxisomal membrane  peroxisomal matrix  plasma membrane  generation of precursor metabolites and energy  lipid metabolic process  prostaglandin metabolic process  spermatogenesis  membrane  palmitoyl-CoA oxidase activity  palmitoyl-CoA oxidase activity  peroxisome fission  fatty acid oxidation  fatty acid oxidation  PDZ domain binding  fatty acid beta-oxidation using acyl-CoA oxidase  fatty acid beta-oxidation using acyl-CoA oxidase  fatty acid beta-oxidation using acyl-CoA oxidase  unsaturated fatty acid metabolic process  alpha-linolenic acid metabolic process  intracellular membrane-bounded organelle  cellular lipid metabolic process  small molecule metabolic process  protein N-terminus binding  flavin adenine dinucleotide binding  lipid homeostasis  lipid homeostasis  FAD binding  positive regulation of cholesterol homeostasis  
Pathways : BIOCARTAMechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]   
Pathways : KEGGFatty acid degradation    alpha-Linolenic acid metabolism    Biosynthesis of unsaturated fatty acids    PPAR signaling pathway    Peroxisome   
NDEx NetworkACOX1
Atlas of Cancer Signalling NetworkACOX1
Wikipedia pathwaysACOX1
Orthology - Evolution
OrthoDB51
GeneTree (enSembl)ENSG00000161533
Phylogenetic Trees/Animal Genes : TreeFamACOX1
HOVERGENQ15067
HOGENOMQ15067
Homologs : HomoloGeneACOX1
Homology/Alignments : Family Browser (UCSC)ACOX1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACOX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACOX1
dbVarACOX1
ClinVarACOX1
1000_GenomesACOX1 
Exome Variant ServerACOX1
ExAC (Exome Aggregation Consortium)ACOX1 (select the gene name)
Genetic variants : HAPMAP51
Genomic Variants (DGV)ACOX1 [DGVbeta]
DECIPHER (Syndromes)17:73937589-73975515  ENSG00000161533
CONAN: Copy Number AnalysisACOX1 
Mutations
ICGC Data PortalACOX1 
TCGA Data PortalACOX1 
Broad Tumor PortalACOX1
OASIS PortalACOX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACOX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACOX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ACOX1
DgiDB (Drug Gene Interaction Database)ACOX1
DoCM (Curated mutations)ACOX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACOX1 (select a term)
intoGenACOX1
Cancer3DACOX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM264470    609751   
Orphanet567   
MedgenACOX1
Genetic Testing Registry ACOX1
NextProtQ15067 [Medical]
TSGene51
GENETestsACOX1
Huge Navigator ACOX1 [HugePedia]
snp3D : Map Gene to Disease51
BioCentury BCIQACOX1
ClinGenACOX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51
Chemical/Pharm GKB GenePA21
Clinical trialACOX1
Miscellaneous
canSAR (ICR)ACOX1 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACOX1
EVEXACOX1
GoPubMedACOX1
iHOPACOX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 11:53:30 CET 2017

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