ACP1 (acid phosphatase 1)

2003-11-01  

Identity

HGNC
LOCATION
2p25.3
LOCUSID
ALIAS
HAAP,LMW-PTP,LMWPTP

Other Information

Locus ID:

NCBI: 52
MIM: 171500
HGNC: 122
Ensembl: ENSG00000143727

Variants:

dbSNP: 52
ClinVar: 52
TCGA: ENSG00000143727
COSMIC: ACP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143727ENST00000272065P24666
ENSG00000143727ENST00000272067P24666
ENSG00000143727ENST00000405233F2Z2Q9
ENSG00000143727ENST00000405364F2Z2R9
ENSG00000143727ENST00000407983P24666
ENSG00000143727ENST00000407983A0A140VK37
ENSG00000143727ENST00000413140G5E9R5
ENSG00000143727ENST00000439645D3YTI2
ENSG00000143727ENST00000442386F2Z2R9
ENSG00000143727ENST00000453390F2Z2Q9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Thiamine metabolismKEGGko00730
Riboflavin metabolismKEGGko00740
Adherens junctionKEGGko04520
Thiamine metabolismKEGGhsa00730
Riboflavin metabolismKEGGhsa00740
Adherens junctionKEGGhsa04520
Metabolic pathwaysKEGGhsa01100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445187OsteonecrosisDiseaseMultilinkAnnotationassociated25999454

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
214232392012A genome-wide association study of attempted suicide.49
208161952010Analyses of shared genetic factors between asthma and obesity in children.43
228540472012S-glutathionylation of LMW-PTP regulates VEGF-mediated FAK activation and endothelial cell migration.25
171716502007Dopaminergic polymorphisms in Tourette syndrome: association with the DAT gene (SLC6A3).20
168939012006Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase.18
124092702002Association of the acid phosphatase (ACP1) gene with triglyceride levels in obese women.12
160362212005Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers.12
128150622003Lymphocyte function-associated antigen-1-mediated T cell adhesion is impaired by low molecular weight phosphotyrosine phosphatase-dependent inhibition of FAK activity.11

Citation

Dessen P

ACP1 (acid phosphatase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/553/acp1