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ACP2 (acid phosphatase 2, lysosomal)

Identity

Alias (NCBI)LAP
HGNC (Hugo) ACP2
HGNC Alias symbLAP
HGNC Alias namelysosomal acid phosphatase
LocusID (NCBI) 53
Atlas_Id 554
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 47239302 and ends at 47248814 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACP2 (11p11.2) / KIRREL3 (11q24.2)ACP2 (11p11.2) / MRVI1-AS1 (11p15.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ACP2   123
Cards
Entrez_Gene (NCBI)ACP2    acid phosphatase 2, lysosomal
AliasesLAP
GeneCards (Weizmann)ACP2
Ensembl hg19 (Hinxton)ENSG00000134575 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134575 [Gene_View]  ENSG00000134575 [Sequence]  chr11:47239302-47248814 [Contig_View]  ACP2 [Vega]
ICGC DataPortalENSG00000134575
TCGA cBioPortalACP2
AceView (NCBI)ACP2
Genatlas (Paris)ACP2
SOURCE (Princeton)ACP2
Genetics Home Reference (NIH)ACP2
Genomic and cartography
GoldenPath hg38 (UCSC)ACP2  -     chr11:47239302-47248814 -  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACP2  -     11p11.2   [Description]    (hg19-Feb_2009)
GoldenPathACP2 - 11p11.2 [CytoView hg19]  ACP2 - 11p11.2 [CytoView hg38]
ImmunoBaseENSG00000134575
Genome Data Viewer NCBIACP2 [Mapview hg19]  
OMIM171650   200950   
Gene and transcription
Genbank (Entrez)AK298122 AK298439 AK299382 AK300569 AK300911
RefSeq transcript (Entrez)NM_001131064 NM_001302489 NM_001302490 NM_001302491 NM_001302492 NM_001357016 NM_001610
Consensus coding sequences : CCDS (NCBI)ACP2
Gene ExpressionACP2 [ NCBI-GEO ]   ACP2 [ EBI - ARRAY_EXPRESS ]   ACP2 [ SEEK ]   ACP2 [ MEM ]
Gene Expression Viewer (FireBrowse)ACP2 [ Firebrowse - Broad ]
GenevisibleExpression of ACP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53
GTEX Portal (Tissue expression)ACP2
Human Protein AtlasENSG00000134575-ACP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11117   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11117  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11117
Catalytic activity : Enzyme3.1.3.2 [ Enzyme-Expasy ]   3.1.3.23.1.3.2 [ IntEnz-EBI ]   3.1.3.2 [ BRENDA ]   3.1.3.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP11117
Domaine pattern : Prosite (Expaxy)HIS_ACID_PHOSPHAT_1 (PS00616)    HIS_ACID_PHOSPHAT_2 (PS00778)   
Domains : Interpro (EBI)Acid_Pase_AS    His_Pase_clade-2    His_PPase_superfam   
Domain families : Pfam (Sanger)His_Phos_2 (PF00328)   
Domain families : Pfam (NCBI)pfam00328   
Conserved Domain (NCBI)ACP2
SuperfamilyP11117
AlphaFold pdb e-kbP11117   
Human Protein Atlas [tissue]ENSG00000134575-ACP2 [tissue]
HPRD01375
Protein Interaction databases
DIP (DOE-UCLA)P11117
IntAct (EBI)P11117
BioGRIDACP2
STRING (EMBL)ACP2
ZODIACACP2
Ontologies - Pathways
QuickGOP11117
Ontology : AmiGOacid phosphatase activity  protein binding  lysosome  lysosome  lysosomal membrane  lysosome organization  membrane  integral component of membrane  dephosphorylation  phosphatase activity  lysosomal lumen  extracellular exosome  
Ontology : EGO-EBIacid phosphatase activity  protein binding  lysosome  lysosome  lysosomal membrane  lysosome organization  membrane  integral component of membrane  dephosphorylation  phosphatase activity  lysosomal lumen  extracellular exosome  
Pathways : KEGGRiboflavin metabolism    Lysosome   
NDEx NetworkACP2
Atlas of Cancer Signalling NetworkACP2
Wikipedia pathwaysACP2
Orthology - Evolution
OrthoDB53
GeneTree (enSembl)ENSG00000134575
Phylogenetic Trees/Animal Genes : TreeFamACP2
Homologs : HomoloGeneACP2
Homology/Alignments : Family Browser (UCSC)ACP2
Gene fusions - Rearrangements
Fusion : QuiverACP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACP2
dbVarACP2
ClinVarACP2
MonarchACP2
1000_GenomesACP2 
Exome Variant ServerACP2
GNOMAD BrowserENSG00000134575
Varsome BrowserACP2
ACMGACP2 variants
VarityP11117
Genomic Variants (DGV)ACP2 [DGVbeta]
DECIPHERACP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACP2 
Mutations
ICGC Data PortalACP2 
TCGA Data PortalACP2 
Broad Tumor PortalACP2
OASIS PortalACP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DACP2
Mutations and Diseases : HGMDACP2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaACP2
DgiDB (Drug Gene Interaction Database)ACP2
DoCM (Curated mutations)ACP2
CIViC (Clinical Interpretations of Variants in Cancer)ACP2
Cancer3DACP2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM171650    200950   
Orphanet
DisGeNETACP2
MedgenACP2
Genetic Testing Registry ACP2
NextProtP11117 [Medical]
GENETestsACP2
Target ValidationACP2
Huge Navigator ACP2 [HugePedia]
ClinGenACP2
Clinical trials, drugs, therapy
MyCancerGenomeACP2
Protein Interactions : CTDACP2
Pharm GKB GenePA24447
PharosP11117
Clinical trialACP2
Miscellaneous
canSAR (ICR)ACP2
HarmonizomeACP2
DataMed IndexACP2
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXACP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:58:15 CEST 2021

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