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ACP5 (acid phosphatase 5, tartrate resistant)

Identity

Alias_symbol (synonym)TRAP
HPAP
Other aliasTRACP5a
TRACP5b
TrATPase
HGNC (Hugo) ACP5
LocusID (NCBI) 54
Atlas_Id 555
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 11574660 and ends at 11578780 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACP5 (19p13.2) / GTF2F1 (19p13.3)ACP5 (19p13.2) / PSAP (10q22.1)GTF2F1 (19p13.3) / ACP5 (19p13.2)
PSAP (10q22.1) / ACP5 (19p13.2)ACP5 19p13.2 / GTF2F1 19p13.3GTF2F1 19p13.3 / ACP5 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Enchondromatosis


External links

Nomenclature
HGNC (Hugo)ACP5   124
Cards
Entrez_Gene (NCBI)ACP5  54  acid phosphatase 5, tartrate resistant
AliasesHPAP; TRACP5a; TRACP5b; TRAP; 
TrATPase
GeneCards (Weizmann)ACP5
Ensembl hg19 (Hinxton)ENSG00000102575 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102575 [Gene_View]  chr19:11574660-11578780 [Contig_View]  ACP5 [Vega]
ICGC DataPortalENSG00000102575
TCGA cBioPortalACP5
AceView (NCBI)ACP5
Genatlas (Paris)ACP5
WikiGenes54
SOURCE (Princeton)ACP5
Genetics Home Reference (NIH)ACP5
Genomic and cartography
GoldenPath hg38 (UCSC)ACP5  -     chr19:11574660-11578780 -  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACP5  -     19p13.2   [Description]    (hg19-Feb_2009)
EnsemblACP5 - 19p13.2 [CytoView hg19]  ACP5 - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBIACP5 [Mapview hg19]  ACP5 [Mapview hg38]
OMIM171640   607944   
Gene and transcription
Genbank (Entrez)AK225912 AK290717 AK307164 BC025414 BC111014
RefSeq transcript (Entrez)NM_001111034 NM_001111035 NM_001111036 NM_001322023 NM_001611
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACP5
Cluster EST : UnigeneHs.1211 [ NCBI ]
CGAP (NCI)Hs.1211
Alternative Splicing GalleryENSG00000102575
Gene ExpressionACP5 [ NCBI-GEO ]   ACP5 [ EBI - ARRAY_EXPRESS ]   ACP5 [ SEEK ]   ACP5 [ MEM ]
Gene Expression Viewer (FireBrowse)ACP5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54
GTEX Portal (Tissue expression)ACP5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13686   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13686  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13686
Splice isoforms : SwissVarP13686
Catalytic activity : Enzyme3.1.3.2 [ Enzyme-Expasy ]   3.1.3.23.1.3.2 [ IntEnz-EBI ]   3.1.3.2 [ BRENDA ]   3.1.3.2 [ KEGG ]   
PhosPhoSitePlusP13686
Domains : Interpro (EBI)Acid_Pase_5    Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Conserved Domain (NCBI)ACP5
DMDM Disease mutations54
Blocks (Seattle)ACP5
PDB (SRS)1WAR    2BQ8   
PDB (PDBSum)1WAR    2BQ8   
PDB (IMB)1WAR    2BQ8   
PDB (RSDB)1WAR    2BQ8   
Structural Biology KnowledgeBase1WAR    2BQ8   
SCOP (Structural Classification of Proteins)1WAR    2BQ8   
CATH (Classification of proteins structures)1WAR    2BQ8   
SuperfamilyP13686
Human Protein AtlasENSG00000102575
Peptide AtlasP13686
HPRD01374
IPIIPI00419240   
Protein Interaction databases
DIP (DOE-UCLA)P13686
IntAct (EBI)P13686
FunCoupENSG00000102575
BioGRIDACP5
STRING (EMBL)ACP5
ZODIACACP5
Ontologies - Pathways
QuickGOP13686
Ontology : AmiGOacid phosphatase activity  lysosome  cytosol  riboflavin metabolic process  ferrous iron binding  ferric iron binding  integral component of membrane  dephosphorylation  extracellular exosome  
Ontology : EGO-EBIacid phosphatase activity  lysosome  cytosol  riboflavin metabolic process  ferrous iron binding  ferric iron binding  integral component of membrane  dephosphorylation  extracellular exosome  
Pathways : KEGGRiboflavin metabolism    Lysosome    Osteoclast differentiation    Rheumatoid arthritis   
NDEx NetworkACP5
Atlas of Cancer Signalling NetworkACP5
Wikipedia pathwaysACP5
Orthology - Evolution
OrthoDB54
GeneTree (enSembl)ENSG00000102575
Phylogenetic Trees/Animal Genes : TreeFamACP5
HOVERGENP13686
HOGENOMP13686
Homologs : HomoloGeneACP5
Homology/Alignments : Family Browser (UCSC)ACP5
Gene fusions - Rearrangements
Fusion : MitelmanACP5/GTF2F1 [19p13.2/19p13.3]  
Fusion : MitelmanGTF2F1/ACP5 [19p13.3/19p13.2]  [t(19;19)(p13;p13)]  
Fusion: TCGAACP5 19p13.2 GTF2F1 19p13.3 SKCM
Fusion: TCGAGTF2F1 19p13.3 ACP5 19p13.2 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACP5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACP5
dbVarACP5
ClinVarACP5
1000_GenomesACP5 
Exome Variant ServerACP5
ExAC (Exome Aggregation Consortium)ACP5 (select the gene name)
Genetic variants : HAPMAP54
Genomic Variants (DGV)ACP5 [DGVbeta]
DECIPHERACP5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACP5 
Mutations
ICGC Data PortalACP5 
TCGA Data PortalACP5 
Broad Tumor PortalACP5
OASIS PortalACP5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACP5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACP5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch ACP5
DgiDB (Drug Gene Interaction Database)ACP5
DoCM (Curated mutations)ACP5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACP5 (select a term)
intoGenACP5
Cancer3DACP5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM171640    607944   
Orphanet2842   
MedgenACP5
Genetic Testing Registry ACP5
NextProtP13686 [Medical]
TSGene54
GENETestsACP5
Target ValidationACP5
Huge Navigator ACP5 [HugePedia]
snp3D : Map Gene to Disease54
BioCentury BCIQACP5
ClinGenACP5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54
Chemical/Pharm GKB GenePA24448
Clinical trialACP5
Miscellaneous
canSAR (ICR)ACP5 (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACP5
EVEXACP5
GoPubMedACP5
iHOPACP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 18:55:57 CEST 2017

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