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ACP5 (acid phosphatase 5, tartrate resistant)

Identity

Alias (NCBI)HPAP
TRACP5a
TRACP5b
TRAP
TrATPase
HGNC (Hugo) ACP5
HGNC Alias symbTRAP
HPAP
HGNC Alias nametartrate-resistant acid phosphatase
 human purple acid phosphatase
LocusID (NCBI) 54
Atlas_Id 555
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 11574660 and ends at 11577645 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACP5 (19p13.2) / GTF2F1 (19p13.3)ACP5 (19p13.2) / PSAP (10q22.1)GTF2F1 (19p13.3) / ACP5 (19p13.2)
PSAP (10q22.1) / ACP5 (19p13.2)ACP5 19p13.2 / GTF2F1 19p13.3GTF2F1 19p13.3 / ACP5 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Enchondromatosis


External links

 

Nomenclature
HGNC (Hugo)ACP5   124
Cards
Entrez_Gene (NCBI)ACP5    acid phosphatase 5, tartrate resistant
AliasesHPAP; TRACP5a; TRACP5b; TRAP; 
TrATPase
GeneCards (Weizmann)ACP5
Ensembl hg19 (Hinxton)ENSG00000102575 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102575 [Gene_View]  ENSG00000102575 [Sequence]  chr19:11574660-11577645 [Contig_View]  ACP5 [Vega]
ICGC DataPortalENSG00000102575
TCGA cBioPortalACP5
AceView (NCBI)ACP5
Genatlas (Paris)ACP5
SOURCE (Princeton)ACP5
Genetics Home Reference (NIH)ACP5
Genomic and cartography
GoldenPath hg38 (UCSC)ACP5  -     chr19:11574660-11577645 -  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACP5  -     19p13.2   [Description]    (hg19-Feb_2009)
GoldenPathACP5 - 19p13.2 [CytoView hg19]  ACP5 - 19p13.2 [CytoView hg38]
ImmunoBaseENSG00000102575
Genome Data Viewer NCBIACP5 [Mapview hg19]  
OMIM171640   607944   
Gene and transcription
Genbank (Entrez)AK225912 AK290717 AK307164 BC025414 BC111014
RefSeq transcript (Entrez)NM_001111034 NM_001111035 NM_001111036 NM_001322023 NM_001611
Consensus coding sequences : CCDS (NCBI)ACP5
Gene ExpressionACP5 [ NCBI-GEO ]   ACP5 [ EBI - ARRAY_EXPRESS ]   ACP5 [ SEEK ]   ACP5 [ MEM ]
Gene Expression Viewer (FireBrowse)ACP5 [ Firebrowse - Broad ]
GenevisibleExpression of ACP5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54
GTEX Portal (Tissue expression)ACP5
Human Protein AtlasENSG00000102575-ACP5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13686   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13686  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13686
Catalytic activity : Enzyme3.1.3.2 [ Enzyme-Expasy ]   3.1.3.23.1.3.2 [ IntEnz-EBI ]   3.1.3.2 [ BRENDA ]   3.1.3.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP13686
Domains : Interpro (EBI)Acid_PPase    Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Conserved Domain (NCBI)ACP5
PDB (RSDB)1WAR    2BQ8   
PDB Europe1WAR    2BQ8   
PDB (PDBSum)1WAR    2BQ8   
PDB (IMB)1WAR    2BQ8   
Structural Biology KnowledgeBase1WAR    2BQ8   
SCOP (Structural Classification of Proteins)1WAR    2BQ8   
CATH (Classification of proteins structures)1WAR    2BQ8   
SuperfamilyP13686
AlphaFold pdb e-kbP13686   
Human Protein Atlas [tissue]ENSG00000102575-ACP5 [tissue]
HPRD01374
Protein Interaction databases
DIP (DOE-UCLA)P13686
IntAct (EBI)P13686
BioGRIDACP5
STRING (EMBL)ACP5
ZODIACACP5
Ontologies - Pathways
QuickGOP13686
Ontology : AmiGOossification  acid phosphatase activity  lysosome  cytosol  riboflavin metabolic process  ferrous iron binding  ferrous iron binding  ferric iron binding  ferric iron binding  integral component of membrane  dephosphorylation  response to lipopolysaccharide  negative regulation of interleukin-1 beta production  negative regulation of interleukin-12 production  negative regulation of tumor necrosis factor production  negative regulation of superoxide anion generation  response to cytokine  negative regulation of nitric oxide biosynthetic process  bone resorption  negative regulation of inflammatory response  defense response to Gram-positive bacterium  bone morphogenesis  
Ontology : EGO-EBIossification  acid phosphatase activity  lysosome  cytosol  riboflavin metabolic process  ferrous iron binding  ferrous iron binding  ferric iron binding  ferric iron binding  integral component of membrane  dephosphorylation  response to lipopolysaccharide  negative regulation of interleukin-1 beta production  negative regulation of interleukin-12 production  negative regulation of tumor necrosis factor production  negative regulation of superoxide anion generation  response to cytokine  negative regulation of nitric oxide biosynthetic process  bone resorption  negative regulation of inflammatory response  defense response to Gram-positive bacterium  bone morphogenesis  
Pathways : KEGGRiboflavin metabolism    Lysosome    Osteoclast differentiation    Rheumatoid arthritis   
NDEx NetworkACP5
Atlas of Cancer Signalling NetworkACP5
Wikipedia pathwaysACP5
Orthology - Evolution
OrthoDB54
GeneTree (enSembl)ENSG00000102575
Phylogenetic Trees/Animal Genes : TreeFamACP5
Homologs : HomoloGeneACP5
Homology/Alignments : Family Browser (UCSC)ACP5
Gene fusions - Rearrangements
Fusion : MitelmanACP5/GTF2F1 [19p13.2/19p13.3]  
Fusion : MitelmanGTF2F1/ACP5 [19p13.3/19p13.2]  
Fusion : QuiverACP5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACP5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACP5
dbVarACP5
ClinVarACP5
MonarchACP5
1000_GenomesACP5 
Exome Variant ServerACP5
GNOMAD BrowserENSG00000102575
Varsome BrowserACP5
ACMGACP5 variants
VarityP13686
Genomic Variants (DGV)ACP5 [DGVbeta]
DECIPHERACP5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACP5 
Mutations
ICGC Data PortalACP5 
TCGA Data PortalACP5 
Broad Tumor PortalACP5
OASIS PortalACP5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACP5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DACP5
Mutations and Diseases : HGMDACP5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaACP5
DgiDB (Drug Gene Interaction Database)ACP5
DoCM (Curated mutations)ACP5
CIViC (Clinical Interpretations of Variants in Cancer)ACP5
Cancer3DACP5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM171640    607944   
Orphanet2842   
DisGeNETACP5
MedgenACP5
Genetic Testing Registry ACP5
NextProtP13686 [Medical]
GENETestsACP5
Target ValidationACP5
Huge Navigator ACP5 [HugePedia]
ClinGenACP5
Clinical trials, drugs, therapy
MyCancerGenomeACP5
Protein Interactions : CTDACP5
Pharm GKB GenePA24448
PharosP13686
Clinical trialACP5
Miscellaneous
canSAR (ICR)ACP5
HarmonizomeACP5
DataMed IndexACP5
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXACP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:58:15 CEST 2021

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