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ACR (acrosin)

Identity

Other alias-
HGNC (Hugo) ACR
LocusID (NCBI) 49
Atlas_Id 60097
Location 22q13.33  [Link to chromosome band 22q13]
Location_base_pair Starts at 50738224 and ends at 50745299 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SHANK3 (22q13.33) / ACR (22q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACR   126
Cards
Entrez_Gene (NCBI)ACR  49  acrosin
Aliases
GeneCards (Weizmann)ACR
Ensembl hg19 (Hinxton)ENSG00000100312 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100312 [Gene_View]  chr22:50738224-50745299 [Contig_View]  ACR [Vega]
ICGC DataPortalENSG00000100312
TCGA cBioPortalACR
AceView (NCBI)ACR
Genatlas (Paris)ACR
WikiGenes49
SOURCE (Princeton)ACR
Genetics Home Reference (NIH)ACR
Genomic and cartography
GoldenPath hg38 (UCSC)ACR  -     chr22:50738224-50745299 +  22q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACR  -     22q13.33   [Description]    (hg19-Feb_2009)
EnsemblACR - 22q13.33 [CytoView hg19]  ACR - 22q13.33 [CytoView hg38]
Mapping of homologs : NCBIACR [Mapview hg19]  ACR [Mapview hg38]
OMIM102480   
Gene and transcription
Genbank (Entrez)AK310316 BC111593 CR456366 CU012933 CU013221
RefSeq transcript (Entrez)NM_001097
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACR
Cluster EST : UnigeneHs.370870 [ NCBI ]
CGAP (NCI)Hs.370870
Alternative Splicing GalleryENSG00000100312
Gene ExpressionACR [ NCBI-GEO ]   ACR [ EBI - ARRAY_EXPRESS ]   ACR [ SEEK ]   ACR [ MEM ]
Gene Expression Viewer (FireBrowse)ACR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)49
GTEX Portal (Tissue expression)ACR
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10323   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10323  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10323
Splice isoforms : SwissVarP10323
Catalytic activity : Enzyme3.4.21.10 [ Enzyme-Expasy ]   3.4.21.103.4.21.10 [ IntEnz-EBI ]   3.4.21.10 [ BRENDA ]   3.4.21.10 [ KEGG ]   
PhosPhoSitePlusP10323
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Pept_S1A_acrosin    Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)ACR
DMDM Disease mutations49
Blocks (Seattle)ACR
SuperfamilyP10323
Human Protein AtlasENSG00000100312
Peptide AtlasP10323
HPRD06342
IPIIPI00289614   IPI00985255   
Protein Interaction databases
DIP (DOE-UCLA)P10323
IntAct (EBI)P10323
FunCoupENSG00000100312
BioGRIDACR
STRING (EMBL)ACR
ZODIACACR
Ontologies - Pathways
QuickGOP10323
Ontology : AmiGOprotease binding  acrosome matrix dispersal  DNA binding  amidase activity  serine-type endopeptidase activity  copper ion binding  protein binding  mannose binding  extracellular region  nucleus  Golgi-associated vesicle  activation of adenylate cyclase activity  single fertilization  binding of sperm to zona pellucida  acrosome reaction  acrosome reaction  penetration of zona pellucida  drug binding  zinc ion binding  fucose binding  acrosomal matrix  protein complex  response to steroid hormone  
Ontology : EGO-EBIprotease binding  acrosome matrix dispersal  DNA binding  amidase activity  serine-type endopeptidase activity  copper ion binding  protein binding  mannose binding  extracellular region  nucleus  Golgi-associated vesicle  activation of adenylate cyclase activity  single fertilization  binding of sperm to zona pellucida  acrosome reaction  acrosome reaction  penetration of zona pellucida  drug binding  zinc ion binding  fucose binding  acrosomal matrix  protein complex  response to steroid hormone  
NDEx NetworkACR
Atlas of Cancer Signalling NetworkACR
Wikipedia pathwaysACR
Orthology - Evolution
OrthoDB49
GeneTree (enSembl)ENSG00000100312
Phylogenetic Trees/Animal Genes : TreeFamACR
HOVERGENP10323
HOGENOMP10323
Homologs : HomoloGeneACR
Homology/Alignments : Family Browser (UCSC)ACR
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACR
dbVarACR
ClinVarACR
1000_GenomesACR 
Exome Variant ServerACR
ExAC (Exome Aggregation Consortium)ACR (select the gene name)
Genetic variants : HAPMAP49
Genomic Variants (DGV)ACR [DGVbeta]
DECIPHERACR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACR 
Mutations
ICGC Data PortalACR 
TCGA Data PortalACR 
Broad Tumor PortalACR
OASIS PortalACR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ACR
DgiDB (Drug Gene Interaction Database)ACR
DoCM (Curated mutations)ACR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACR (select a term)
intoGenACR
Cancer3DACR(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM102480   
Orphanet
MedgenACR
Genetic Testing Registry ACR
NextProtP10323 [Medical]
TSGene49
GENETestsACR
Target ValidationACR
Huge Navigator ACR [HugePedia]
snp3D : Map Gene to Disease49
BioCentury BCIQACR
ClinGenACR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD49
Chemical/Pharm GKB GenePA24451
Clinical trialACR
Miscellaneous
canSAR (ICR)ACR (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACR
EVEXACR
GoPubMedACR
iHOPACR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:00:47 CEST 2017

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