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ACSL1 (acyl-CoA synthetase long-chain family member 1)

Identity

Alias_namesFACL2
fatty-acid-Coenzyme A ligase
Alias_symbol (synonym)LACS2
LACS
ACS1
LACS1
FACL1
Other alias
HGNC (Hugo) ACSL1
LocusID (NCBI) 2180
Atlas_Id 559
Location 4q35.1  [Link to chromosome band 4q35]
Location_base_pair Starts at 184755595 and ends at 184812259 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACSL1 (4q35.1) / ETV6 (12p13.2)ETV6 (12p13.2) / ACSL1 (4q35.1)FAT1 (4q35.2) / ACSL1 (4q35.1)
MPO (17q22) / ACSL1 (4q35.1)FAT1 4q35.2 / ACSL1 4q35.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACSL1   3569
Cards
Entrez_Gene (NCBI)ACSL1  2180  acyl-CoA synthetase long-chain family member 1
AliasesACS1; FACL1; FACL2; LACS; 
LACS1; LACS2
GeneCards (Weizmann)ACSL1
Ensembl hg19 (Hinxton)ENSG00000151726 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151726 [Gene_View]  chr4:184755595-184812259 [Contig_View]  ACSL1 [Vega]
ICGC DataPortalENSG00000151726
TCGA cBioPortalACSL1
AceView (NCBI)ACSL1
Genatlas (Paris)ACSL1
WikiGenes2180
SOURCE (Princeton)ACSL1
Genetics Home Reference (NIH)ACSL1
Genomic and cartography
GoldenPath hg38 (UCSC)ACSL1  -     chr4:184755595-184812259 -  4q35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACSL1  -     4q35.1   [Description]    (hg19-Feb_2009)
EnsemblACSL1 - 4q35.1 [CytoView hg19]  ACSL1 - 4q35.1 [CytoView hg38]
Mapping of homologs : NCBIACSL1 [Mapview hg19]  ACSL1 [Mapview hg38]
OMIM152425   
Gene and transcription
Genbank (Entrez)AK096117 AK292798 AK296550 AK296826 AK303486
RefSeq transcript (Entrez)NM_001286708 NM_001286710 NM_001286711 NM_001286712 NM_001995
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACSL1
Cluster EST : UnigeneHs.406678 [ NCBI ]
CGAP (NCI)Hs.406678
Alternative Splicing GalleryENSG00000151726
Gene ExpressionACSL1 [ NCBI-GEO ]   ACSL1 [ EBI - ARRAY_EXPRESS ]   ACSL1 [ SEEK ]   ACSL1 [ MEM ]
Gene Expression Viewer (FireBrowse)ACSL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2180
GTEX Portal (Tissue expression)ACSL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33121   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP33121  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP33121
Splice isoforms : SwissVarP33121
Catalytic activity : Enzyme6.2.1.3 [ Enzyme-Expasy ]   6.2.1.36.2.1.3 [ IntEnz-EBI ]   6.2.1.3 [ BRENDA ]   6.2.1.3 [ KEGG ]   
PhosPhoSitePlusP33121
Domaine pattern : Prosite (Expaxy)AMP_BINDING (PS00455)   
Domains : Interpro (EBI)AMP-binding_CS    AMP-dep_Synth/Lig   
Domain families : Pfam (Sanger)AMP-binding (PF00501)   
Domain families : Pfam (NCBI)pfam00501   
Conserved Domain (NCBI)ACSL1
DMDM Disease mutations2180
Blocks (Seattle)ACSL1
SuperfamilyP33121
Human Protein AtlasENSG00000151726
Peptide AtlasP33121
HPRD01068
IPIIPI00012728   IPI00401448   IPI00967718   IPI00965024   IPI00982418   IPI00942534   IPI00965893   IPI00965595   IPI00964254   
Protein Interaction databases
DIP (DOE-UCLA)P33121
IntAct (EBI)P33121
FunCoupENSG00000151726
BioGRIDACSL1
STRING (EMBL)ACSL1
ZODIACACSL1
Ontologies - Pathways
QuickGOP33121
Ontology : AmiGOlong-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  ATP binding  mitochondrion  mitochondrial outer membrane  peroxisomal membrane  endoplasmic reticulum membrane  plasma membrane  triglyceride metabolic process  response to nutrient  lipid biosynthetic process  response to organic cyclic compound  membrane  integral component of membrane  adiponectin-activated signaling pathway  response to oleic acid  long-chain fatty-acyl-CoA biosynthetic process  alpha-linolenic acid metabolic process  xenobiotic catabolic process  response to drug  linoleic acid metabolic process  long-chain fatty acid import  positive regulation of protein serine/threonine kinase activity  decanoate--CoA ligase activity  
Ontology : EGO-EBIlong-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  ATP binding  mitochondrion  mitochondrial outer membrane  peroxisomal membrane  endoplasmic reticulum membrane  plasma membrane  triglyceride metabolic process  response to nutrient  lipid biosynthetic process  response to organic cyclic compound  membrane  integral component of membrane  adiponectin-activated signaling pathway  response to oleic acid  long-chain fatty-acyl-CoA biosynthetic process  alpha-linolenic acid metabolic process  xenobiotic catabolic process  response to drug  linoleic acid metabolic process  long-chain fatty acid import  positive regulation of protein serine/threonine kinase activity  decanoate--CoA ligase activity  
Pathways : KEGGFatty acid degradation    PPAR signaling pathway    Peroxisome    Adipocytokine signaling pathway   
NDEx NetworkACSL1
Atlas of Cancer Signalling NetworkACSL1
Wikipedia pathwaysACSL1
Orthology - Evolution
OrthoDB2180
GeneTree (enSembl)ENSG00000151726
Phylogenetic Trees/Animal Genes : TreeFamACSL1
HOVERGENP33121
HOGENOMP33121
Homologs : HomoloGeneACSL1
Homology/Alignments : Family Browser (UCSC)ACSL1
Gene fusions - Rearrangements
Fusion : MitelmanFAT1/ACSL1 [4q35.2/4q35.1]  [t(4;4)(q35;q35)]  
Fusion: TCGAFAT1 4q35.2 ACSL1 4q35.1 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACSL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACSL1
dbVarACSL1
ClinVarACSL1
1000_GenomesACSL1 
Exome Variant ServerACSL1
ExAC (Exome Aggregation Consortium)ACSL1 (select the gene name)
Genetic variants : HAPMAP2180
Genomic Variants (DGV)ACSL1 [DGVbeta]
DECIPHERACSL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACSL1 
Mutations
ICGC Data PortalACSL1 
TCGA Data PortalACSL1 
Broad Tumor PortalACSL1
OASIS PortalACSL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACSL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACSL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ACSL1
DgiDB (Drug Gene Interaction Database)ACSL1
DoCM (Curated mutations)ACSL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACSL1 (select a term)
intoGenACSL1
Cancer3DACSL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM152425   
Orphanet
MedgenACSL1
Genetic Testing Registry ACSL1
NextProtP33121 [Medical]
TSGene2180
GENETestsACSL1
Target ValidationACSL1
Huge Navigator ACSL1 [HugePedia]
snp3D : Map Gene to Disease2180
BioCentury BCIQACSL1
ClinGenACSL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2180
Chemical/Pharm GKB GenePA27966
Clinical trialACSL1
Miscellaneous
canSAR (ICR)ACSL1 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACSL1
EVEXACSL1
GoPubMedACSL1
iHOPACSL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:54:15 CEST 2017

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