ACSL1 (acyl-CoA synthetase long chain family member 1)

2003-05-01  

Identity

HGNC
LOCATION
4q35.1
LOCUSID
ALIAS
ACS1,FACL1,FACL2,LACS,LACS1,LACS2
FUSION GENES

Other Information

Locus ID:

NCBI: 2180
MIM: 152425
HGNC: 3569
Ensembl: ENSG00000151726

Variants:

dbSNP: 2180
ClinVar: 2180
TCGA: ENSG00000151726
COSMIC: ACSL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151726ENST00000281455P33121
ENSG00000151726ENST00000454703B7Z3Z9
ENSG00000151726ENST00000503407H0Y9U7
ENSG00000151726ENST00000504342P33121
ENSG00000151726ENST00000504900D6RER0
ENSG00000151726ENST00000505492H0Y9Z9
ENSG00000151726ENST00000506733D6RG07
ENSG00000151726ENST00000507295E7EPM6
ENSG00000151726ENST00000513317P33121
ENSG00000151726ENST00000515030P33121
ENSG00000151726ENST00000622937B7Z3Z9

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Fatty acid biosynthesisKEGGko00061
Fatty acid degradationKEGGko00071
PPAR signaling pathwayKEGGko03320
Adipocytokine signaling pathwayKEGGko04920
Fatty acid biosynthesisKEGGhsa00061
Fatty acid degradationKEGGhsa00071
PPAR signaling pathwayKEGGhsa03320
Adipocytokine signaling pathwayKEGGhsa04920
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
beta-Oxidation, acyl-CoA synthesisKEGGhsa_M00086
beta-Oxidation, acyl-CoA synthesisKEGGM00086
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Synthesis of very long-chain fatty acyl-CoAsREACTOMER-HSA-75876
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
alpha-linolenic (omega3) and linoleic (omega6) acid metabolismREACTOMER-HSA-2046104
alpha-linolenic acid (ALA) metabolismREACTOMER-HSA-2046106
Linoleic acid (LA) metabolismREACTOMER-HSA-2046105
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
244627682014MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA.28
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
201768582010Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome.22
201768582010Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome.22
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
168347752006Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains.16
245034772014Protein mediated fatty acid uptake: synergy between CD36/FAT-facilitated transport and acyl-CoA synthetase-driven metabolism.15
259151842015ACSL1 Is Associated With Fetal Programming of Insulin Sensitivity and Cellular Lipid Content.12
233033832013Single-nucleotide polymorphisms inside microRNA target sites influence the susceptibility to type 2 diabetes.11
281328072017HBXIP up-regulates ACSL1 through activating transcriptional factor Sp1 in breast cancer.11

Citation

Dessen P

ACSL1 (acyl-CoA synthetase long chain family member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/559/acsl1