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ACSL3 (acyl-CoA synthetase long-chain family member 3)

Identity

Alias_namesFACL3
fatty-acid-Coenzyme A ligase
Alias_symbol (synonym)ACS3
PRO2194
Other alias
HGNC (Hugo) ACSL3
LocusID (NCBI) 2181
Atlas_Id 45991
Location 2q36.1  [Link to chromosome band 2q36]
Location_base_pair Starts at 222861014 and ends at 222943401 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACSL3 (2q36.1) / ACSL3 (2q36.1)ACSL3 (2q36.1) / ETV1 (7p21.2)ACSL3 (2q36.1) / NIFK (2q14.3)
ACSL3 (2q36.1) / PHGDH (1p12)ACSL3 2q36.1 / ETV1 7p21.2ACSL3 2q36.1 / PHGDH 1p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)ACSL3   3570
Cards
Entrez_Gene (NCBI)ACSL3  2181  acyl-CoA synthetase long-chain family member 3
AliasesACS3; FACL3; PRO2194
GeneCards (Weizmann)ACSL3
Ensembl hg19 (Hinxton)ENSG00000123983 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123983 [Gene_View]  chr2:222861014-222943401 [Contig_View]  ACSL3 [Vega]
ICGC DataPortalENSG00000123983
TCGA cBioPortalACSL3
AceView (NCBI)ACSL3
Genatlas (Paris)ACSL3
WikiGenes2181
SOURCE (Princeton)ACSL3
Genetics Home Reference (NIH)ACSL3
Genomic and cartography
GoldenPath hg38 (UCSC)ACSL3  -     chr2:222861014-222943401 +  2q36.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACSL3  -     2q36.1   [Description]    (hg19-Feb_2009)
EnsemblACSL3 - 2q36.1 [CytoView hg19]  ACSL3 - 2q36.1 [CytoView hg38]
Mapping of homologs : NCBIACSL3 [Mapview hg19]  ACSL3 [Mapview hg38]
OMIM602371   
Gene and transcription
Genbank (Entrez)AB061712 AF116690 AI378485 AK001471 AK023191
RefSeq transcript (Entrez)NM_004457 NM_203372
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACSL3
Cluster EST : UnigeneHs.655772 [ NCBI ]
CGAP (NCI)Hs.655772
Alternative Splicing GalleryENSG00000123983
Gene ExpressionACSL3 [ NCBI-GEO ]   ACSL3 [ EBI - ARRAY_EXPRESS ]   ACSL3 [ SEEK ]   ACSL3 [ MEM ]
Gene Expression Viewer (FireBrowse)ACSL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2181
GTEX Portal (Tissue expression)ACSL3
Human Protein AtlasENSG00000123983-ACSL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95573   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95573  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95573
Splice isoforms : SwissVarO95573
Catalytic activity : Enzyme6.2.1.3 [ Enzyme-Expasy ]   6.2.1.36.2.1.3 [ IntEnz-EBI ]   6.2.1.3 [ BRENDA ]   6.2.1.3 [ KEGG ]   
PhosPhoSitePlusO95573
Domaine pattern : Prosite (Expaxy)AMP_BINDING (PS00455)   
Domains : Interpro (EBI)AMP-binding_CS    AMP-dep_Synth/Lig   
Domain families : Pfam (Sanger)AMP-binding (PF00501)   
Domain families : Pfam (NCBI)pfam00501   
Conserved Domain (NCBI)ACSL3
DMDM Disease mutations2181
Blocks (Seattle)ACSL3
SuperfamilyO95573
Human Protein Atlas [tissue]ENSG00000123983-ACSL3 [tissue]
Peptide AtlasO95573
HPRD03845
IPIIPI00031397   IPI00383347   IPI00916682   IPI00916819   IPI00917636   IPI01015237   IPI01014797   
Protein Interaction databases
DIP (DOE-UCLA)O95573
IntAct (EBI)O95573
FunCoupENSG00000123983
BioGRIDACSL3
STRING (EMBL)ACSL3
ZODIACACSL3
Ontologies - Pathways
QuickGOO95573
Ontology : AmiGOlong-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  ATP binding  mitochondrial outer membrane  peroxisomal membrane  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  lipid particle  fatty acid biosynthetic process  brain development  response to nutrient  response to organic cyclic compound  membrane  integral component of membrane  protein kinase binding  protein domain specific binding  very-low-density lipoprotein particle assembly  long-chain fatty-acyl-CoA biosynthetic process  positive regulation of Golgi to plasma membrane protein transport  long-chain fatty acid import  perinuclear region of cytoplasm  positive regulation of secretion  decanoate--CoA ligase activity  positive regulation of phosphatidylcholine biosynthetic process  
Ontology : EGO-EBIlong-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  ATP binding  mitochondrial outer membrane  peroxisomal membrane  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  lipid particle  fatty acid biosynthetic process  brain development  response to nutrient  response to organic cyclic compound  membrane  integral component of membrane  protein kinase binding  protein domain specific binding  very-low-density lipoprotein particle assembly  long-chain fatty-acyl-CoA biosynthetic process  positive regulation of Golgi to plasma membrane protein transport  long-chain fatty acid import  perinuclear region of cytoplasm  positive regulation of secretion  decanoate--CoA ligase activity  positive regulation of phosphatidylcholine biosynthetic process  
Pathways : KEGGFatty acid degradation    PPAR signaling pathway    Peroxisome    Adipocytokine signaling pathway   
NDEx NetworkACSL3
Atlas of Cancer Signalling NetworkACSL3
Wikipedia pathwaysACSL3
Orthology - Evolution
OrthoDB2181
GeneTree (enSembl)ENSG00000123983
Phylogenetic Trees/Animal Genes : TreeFamACSL3
HOVERGENO95573
HOGENOMO95573
Homologs : HomoloGeneACSL3
Homology/Alignments : Family Browser (UCSC)ACSL3
Gene fusions - Rearrangements
Fusion : MitelmanACSL3/ETV1 [2q36.1/7p21.2]  
Fusion : MitelmanACSL3/PHGDH [2q36.1/1p12]  [t(1;2)(p12;q36)]  
Fusion: TCGA_MDACCACSL3 2q36.1 PHGDH 1p12 LUAD
Tumor Fusion PortalACSL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACSL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACSL3
dbVarACSL3
ClinVarACSL3
1000_GenomesACSL3 
Exome Variant ServerACSL3
ExAC (Exome Aggregation Consortium)ENSG00000123983
GNOMAD BrowserENSG00000123983
Genetic variants : HAPMAP2181
Genomic Variants (DGV)ACSL3 [DGVbeta]
DECIPHERACSL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACSL3 
Mutations
ICGC Data PortalACSL3 
TCGA Data PortalACSL3 
Broad Tumor PortalACSL3
OASIS PortalACSL3 [ Somatic mutations - Copy number]
Cancer Gene: CensusACSL3 
Somatic Mutations in Cancer : COSMICACSL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACSL3
intOGen PortalACSL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ACSL3
DgiDB (Drug Gene Interaction Database)ACSL3
DoCM (Curated mutations)ACSL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACSL3 (select a term)
intoGenACSL3
Cancer3DACSL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602371   
Orphanet
DisGeNETACSL3
MedgenACSL3
Genetic Testing Registry ACSL3
NextProtO95573 [Medical]
TSGene2181
GENETestsACSL3
Target ValidationACSL3
Huge Navigator ACSL3 [HugePedia]
snp3D : Map Gene to Disease2181
BioCentury BCIQACSL3
ClinGenACSL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2181
Chemical/Pharm GKB GenePA27967
Clinical trialACSL3
Miscellaneous
canSAR (ICR)ACSL3 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACSL3
EVEXACSL3
GoPubMedACSL3
iHOPACSL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:01:53 CET 2017

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