Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ACSL4 (acyl-CoA synthetase long-chain family member 4)

Identity

Alias_namesFACL4
MRX63
MRX68
fatty-acid-Coenzyme A ligase, long-chain 4
mental retardation, X-linked 63
mental retardation, X-linked 68
Alias_symbol (synonym)ACS4
LACS4
Other alias
HGNC (Hugo) ACSL4
LocusID (NCBI) 2182
Atlas_Id 45548
Location Xq23  [Link to chromosome band Xq23]
Location_base_pair Starts at 109641330 and ends at 109733403 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACSL4 (Xq23) / ACSL4 (Xq23)ACSL4 (Xq23) / ARRDC3 (5q14.3)ACSL4 (Xq23) / DCAF6 (1q24.2)
ARRDC3 (5q14.3) / ACSL4 (Xq23)SH3D19 (4q31.3) / ACSL4 (Xq23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)ACSL4   3571
Cards
Entrez_Gene (NCBI)ACSL4  2182  acyl-CoA synthetase long-chain family member 4
AliasesACS4; FACL4; LACS4; MRX63; 
MRX68
GeneCards (Weizmann)ACSL4
Ensembl hg19 (Hinxton)ENSG00000068366 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000068366 [Gene_View]  chrX:109641330-109733403 [Contig_View]  ACSL4 [Vega]
ICGC DataPortalENSG00000068366
TCGA cBioPortalACSL4
AceView (NCBI)ACSL4
Genatlas (Paris)ACSL4
WikiGenes2182
SOURCE (Princeton)ACSL4
Genetics Home Reference (NIH)ACSL4
Genomic and cartography
GoldenPath hg38 (UCSC)ACSL4  -     chrX:109641330-109733403 -  Xq23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACSL4  -     Xq23   [Description]    (hg19-Feb_2009)
EnsemblACSL4 - Xq23 [CytoView hg19]  ACSL4 - Xq23 [CytoView hg38]
Mapping of homologs : NCBIACSL4 [Mapview hg19]  ACSL4 [Mapview hg38]
OMIM300157   300387   
Gene and transcription
Genbank (Entrez)AB061713 AB061714 AF030555 AK292070 AK294915
RefSeq transcript (Entrez)NM_001318509 NM_001318510 NM_004458 NM_022977
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACSL4
Cluster EST : UnigeneHs.268785 [ NCBI ]
CGAP (NCI)Hs.268785
Alternative Splicing GalleryENSG00000068366
Gene ExpressionACSL4 [ NCBI-GEO ]   ACSL4 [ EBI - ARRAY_EXPRESS ]   ACSL4 [ SEEK ]   ACSL4 [ MEM ]
Gene Expression Viewer (FireBrowse)ACSL4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2182
GTEX Portal (Tissue expression)ACSL4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60488   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60488  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60488
Splice isoforms : SwissVarO60488
Catalytic activity : Enzyme6.2.1.3 [ Enzyme-Expasy ]   6.2.1.36.2.1.3 [ IntEnz-EBI ]   6.2.1.3 [ BRENDA ]   6.2.1.3 [ KEGG ]   
PhosPhoSitePlusO60488
Domaine pattern : Prosite (Expaxy)AMP_BINDING (PS00455)   
Domains : Interpro (EBI)AMP-binding_CS    AMP-dep_Synth/Lig   
Domain families : Pfam (Sanger)AMP-binding (PF00501)   
Domain families : Pfam (NCBI)pfam00501   
Conserved Domain (NCBI)ACSL4
DMDM Disease mutations2182
Blocks (Seattle)ACSL4
SuperfamilyO60488
Human Protein AtlasENSG00000068366
Peptide AtlasO60488
HPRD02152
IPIIPI00029737   IPI00219897   IPI00908902   IPI00964476   IPI00964244   IPI00964767   IPI00965516   IPI00965300   
Protein Interaction databases
DIP (DOE-UCLA)O60488
IntAct (EBI)O60488
FunCoupENSG00000068366
BioGRIDACSL4
STRING (EMBL)ACSL4
ZODIACACSL4
Ontologies - Pathways
QuickGOO60488
Ontology : AmiGOlong-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  ATP binding  cytoplasm  mitochondrial outer membrane  peroxisomal membrane  endoplasmic reticulum membrane  lipid particle  lipid metabolic process  triglyceride metabolic process  response to nutrient  fatty acid transport  membrane  integral component of membrane  very long-chain fatty acid-CoA ligase activity  long-chain fatty-acyl-CoA biosynthetic process  neuronal cell body  ER-mitochondrion membrane contact site  arachidonate-CoA ligase activity  embryonic process involved in female pregnancy  dendritic spine development  extracellular exosome  response to interleukin-15  decanoate--CoA ligase activity  
Ontology : EGO-EBIlong-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  ATP binding  cytoplasm  mitochondrial outer membrane  peroxisomal membrane  endoplasmic reticulum membrane  lipid particle  lipid metabolic process  triglyceride metabolic process  response to nutrient  fatty acid transport  membrane  integral component of membrane  very long-chain fatty acid-CoA ligase activity  long-chain fatty-acyl-CoA biosynthetic process  neuronal cell body  ER-mitochondrion membrane contact site  arachidonate-CoA ligase activity  embryonic process involved in female pregnancy  dendritic spine development  extracellular exosome  response to interleukin-15  decanoate--CoA ligase activity  
Pathways : KEGGFatty acid degradation    PPAR signaling pathway    Peroxisome    Adipocytokine signaling pathway   
NDEx NetworkACSL4
Atlas of Cancer Signalling NetworkACSL4
Wikipedia pathwaysACSL4
Orthology - Evolution
OrthoDB2182
GeneTree (enSembl)ENSG00000068366
Phylogenetic Trees/Animal Genes : TreeFamACSL4
HOVERGENO60488
HOGENOMO60488
Homologs : HomoloGeneACSL4
Homology/Alignments : Family Browser (UCSC)ACSL4
Gene fusions - Rearrangements
Fusion : MitelmanACSL4/DCAF6 [Xq23/1q24.2]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACSL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACSL4
dbVarACSL4
ClinVarACSL4
1000_GenomesACSL4 
Exome Variant ServerACSL4
ExAC (Exome Aggregation Consortium)ACSL4 (select the gene name)
Genetic variants : HAPMAP2182
Genomic Variants (DGV)ACSL4 [DGVbeta]
DECIPHERACSL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACSL4 
Mutations
ICGC Data PortalACSL4 
TCGA Data PortalACSL4 
Broad Tumor PortalACSL4
OASIS PortalACSL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACSL4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACSL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ACSL4
DgiDB (Drug Gene Interaction Database)ACSL4
DoCM (Curated mutations)ACSL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACSL4 (select a term)
intoGenACSL4
Cancer3DACSL4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300157    300387   
Orphanet3256    11738   
MedgenACSL4
Genetic Testing Registry ACSL4
NextProtO60488 [Medical]
TSGene2182
GENETestsACSL4
Target ValidationACSL4
Huge Navigator ACSL4 [HugePedia]
snp3D : Map Gene to Disease2182
BioCentury BCIQACSL4
ClinGenACSL4 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2182
Chemical/Pharm GKB GenePA27968
Clinical trialACSL4
Miscellaneous
canSAR (ICR)ACSL4 (select the gene name)
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACSL4
EVEXACSL4
GoPubMedACSL4
iHOPACSL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 18:55:59 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.