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ACSL5 (acyl-CoA synthetase long-chain family member 5)

Identity

Alias_namesFACL5
fatty-acid-Coenzyme A ligase
Alias_symbol (synonym)ACS5
ACS2
Other alias
HGNC (Hugo) ACSL5
LocusID (NCBI) 51703
Atlas_Id 50668
Location 10q25.2  [Link to chromosome band 10q25]
Location_base_pair Starts at 112376198 and ends at 112428380 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACSL5 (10q25.2) / ETV6 (12p13.2)B4GALT4 (3q13.32) / ACSL5 (10q25.2)EIF3H (8q23.3) / ACSL5 (10q25.2)
ETV6 (12p13.2) / ACSL5 (10q25.2)ITLN1 (1q23.3) / ACSL5 (10q25.2)ZDHHC6 (10q25.2) / ACSL5 (10q25.2)
B4GALT4 3q13.32 / ACSL5 10q25.2ZDHHC6 10q25.2 / ACSL5 10q25.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACSL5   16526
Cards
Entrez_Gene (NCBI)ACSL5  51703  acyl-CoA synthetase long-chain family member 5
AliasesACS2; ACS5; FACL5
GeneCards (Weizmann)ACSL5
Ensembl hg19 (Hinxton)ENSG00000197142 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197142 [Gene_View]  chr10:112376198-112428380 [Contig_View]  ACSL5 [Vega]
ICGC DataPortalENSG00000197142
TCGA cBioPortalACSL5
AceView (NCBI)ACSL5
Genatlas (Paris)ACSL5
WikiGenes51703
SOURCE (Princeton)ACSL5
Genetics Home Reference (NIH)ACSL5
Genomic and cartography
GoldenPath hg38 (UCSC)ACSL5  -     chr10:112376198-112428380 +  10q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACSL5  -     10q25.2   [Description]    (hg19-Feb_2009)
EnsemblACSL5 - 10q25.2 [CytoView hg19]  ACSL5 - 10q25.2 [CytoView hg38]
Mapping of homologs : NCBIACSL5 [Mapview hg19]  ACSL5 [Mapview hg38]
OMIM605677   
Gene and transcription
Genbank (Entrez)AB033899 AJ496489 AK000339 AK024932 AK222782
RefSeq transcript (Entrez)NM_016234 NM_203379 NM_203380
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACSL5
Cluster EST : UnigeneHs.11638 [ NCBI ]
CGAP (NCI)Hs.11638
Alternative Splicing GalleryENSG00000197142
Gene ExpressionACSL5 [ NCBI-GEO ]   ACSL5 [ EBI - ARRAY_EXPRESS ]   ACSL5 [ SEEK ]   ACSL5 [ MEM ]
Gene Expression Viewer (FireBrowse)ACSL5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51703
GTEX Portal (Tissue expression)ACSL5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULC5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULC5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULC5
Splice isoforms : SwissVarQ9ULC5
Catalytic activity : Enzyme6.2.1.3 [ Enzyme-Expasy ]   6.2.1.36.2.1.3 [ IntEnz-EBI ]   6.2.1.3 [ BRENDA ]   6.2.1.3 [ KEGG ]   
PhosPhoSitePlusQ9ULC5
Domaine pattern : Prosite (Expaxy)AMP_BINDING (PS00455)   
Domains : Interpro (EBI)AMP-binding_CS    AMP-dep_Synth/Lig   
Domain families : Pfam (Sanger)AMP-binding (PF00501)   
Domain families : Pfam (NCBI)pfam00501   
Conserved Domain (NCBI)ACSL5
DMDM Disease mutations51703
Blocks (Seattle)ACSL5
SuperfamilyQ9ULC5
Human Protein AtlasENSG00000197142
Peptide AtlasQ9ULC5
HPRD16139
IPIIPI00008037   IPI00401990   IPI00854706   IPI00411387   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULC5
IntAct (EBI)Q9ULC5
FunCoupENSG00000197142
BioGRIDACSL5
STRING (EMBL)ACSL5
ZODIACACSL5
Ontologies - Pathways
QuickGOQ9ULC5
Ontology : AmiGOlong-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  ATP binding  nucleus  nucleolus  mitochondrion  mitochondrial outer membrane  mitochondrial inner membrane  endoplasmic reticulum membrane  membrane  integral component of membrane  long-chain fatty-acyl-CoA biosynthetic process  decanoate--CoA ligase activity  
Ontology : EGO-EBIlong-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  ATP binding  nucleus  nucleolus  mitochondrion  mitochondrial outer membrane  mitochondrial inner membrane  endoplasmic reticulum membrane  membrane  integral component of membrane  long-chain fatty-acyl-CoA biosynthetic process  decanoate--CoA ligase activity  
Pathways : KEGGFatty acid degradation    PPAR signaling pathway    Peroxisome    Adipocytokine signaling pathway   
NDEx NetworkACSL5
Atlas of Cancer Signalling NetworkACSL5
Wikipedia pathwaysACSL5
Orthology - Evolution
OrthoDB51703
GeneTree (enSembl)ENSG00000197142
Phylogenetic Trees/Animal Genes : TreeFamACSL5
HOVERGENQ9ULC5
HOGENOMQ9ULC5
Homologs : HomoloGeneACSL5
Homology/Alignments : Family Browser (UCSC)ACSL5
Gene fusions - Rearrangements
Fusion : MitelmanB4GALT4/ACSL5 [3q13.32/10q25.2]  [t(3;10)(q13;q25)]  
Fusion : MitelmanZDHHC6/ACSL5 [10q25.2/10q25.2]  [t(10;10)(q25;q25)]  
Fusion: TCGAB4GALT4 3q13.32 ACSL5 10q25.2 LUSC
Fusion: TCGAZDHHC6 10q25.2 ACSL5 10q25.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACSL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACSL5
dbVarACSL5
ClinVarACSL5
1000_GenomesACSL5 
Exome Variant ServerACSL5
ExAC (Exome Aggregation Consortium)ACSL5 (select the gene name)
Genetic variants : HAPMAP51703
Genomic Variants (DGV)ACSL5 [DGVbeta]
DECIPHERACSL5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACSL5 
Mutations
ICGC Data PortalACSL5 
TCGA Data PortalACSL5 
Broad Tumor PortalACSL5
OASIS PortalACSL5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACSL5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACSL5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ACSL5
DgiDB (Drug Gene Interaction Database)ACSL5
DoCM (Curated mutations)ACSL5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACSL5 (select a term)
intoGenACSL5
Cancer3DACSL5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605677   
Orphanet
MedgenACSL5
Genetic Testing Registry ACSL5
NextProtQ9ULC5 [Medical]
TSGene51703
GENETestsACSL5
Target ValidationACSL5
Huge Navigator ACSL5 [HugePedia]
snp3D : Map Gene to Disease51703
BioCentury BCIQACSL5
ClinGenACSL5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51703
Chemical/Pharm GKB GenePA27969
Clinical trialACSL5
Miscellaneous
canSAR (ICR)ACSL5 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACSL5
EVEXACSL5
GoPubMedACSL5
iHOPACSL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:54:16 CEST 2017

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