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ACSL5 (acyl-CoA synthetase long chain family member 5)

Identity

Alias (NCBI)ACS2
ACS5
FACL5
HGNC (Hugo) ACSL5
HGNC Alias symbACS5
ACS2
HGNC Alias nameFACL5 for fatty acid coenzyme A ligase 5
 long-chain acyl-CoA synthetase 5
 long-chain fatty acid coenzyme A ligase 5
 fatty-acid-Coenzyme A ligase, long-chain 5
HGNC Previous nameFACL5
HGNC Previous namefatty-acid-Coenzyme A ligase, long-chain 5
LocusID (NCBI) 51703
Atlas_Id 50668
Location 10q25.2  [Link to chromosome band 10q25]
Location_base_pair Starts at 112375265 and ends at 112428380 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACSL5 (10q25.2) / ETV6 (12p13.2)B4GALT4 (3q13.32) / ACSL5 (10q25.2)EIF3H (8q23.3) / ACSL5 (10q25.2)
ETV6 (12p13.2) / ACSL5 (10q25.2)ITLN1 (1q23.3) / ACSL5 (10q25.2)ZDHHC6 (10q25.2) / ACSL5 (10q25.2)
B4GALT4 3q13.32 / ACSL5 10q25.2ZDHHC6 10q25.2 / ACSL5 10q25.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ACSL5   16526
Cards
Entrez_Gene (NCBI)ACSL5    acyl-CoA synthetase long chain family member 5
AliasesACS2; ACS5; FACL5
GeneCards (Weizmann)ACSL5
Ensembl hg19 (Hinxton)ENSG00000197142 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197142 [Gene_View]  ENSG00000197142 [Sequence]  chr10:112375265-112428380 [Contig_View]  ACSL5 [Vega]
ICGC DataPortalENSG00000197142
TCGA cBioPortalACSL5
AceView (NCBI)ACSL5
Genatlas (Paris)ACSL5
SOURCE (Princeton)ACSL5
Genetics Home Reference (NIH)ACSL5
Genomic and cartography
GoldenPath hg38 (UCSC)ACSL5  -     chr10:112375265-112428380 +  10q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACSL5  -     10q25.2   [Description]    (hg19-Feb_2009)
GoldenPathACSL5 - 10q25.2 [CytoView hg19]  ACSL5 - 10q25.2 [CytoView hg38]
ImmunoBaseENSG00000197142
Genome Data Viewer NCBIACSL5 [Mapview hg19]  
OMIM605677   
Gene and transcription
Genbank (Entrez)AB033899 AJ496489 AK000339 AK024932 AK222782
RefSeq transcript (Entrez)NM_001387037 NM_016234 NM_203379 NM_203380
Consensus coding sequences : CCDS (NCBI)ACSL5
Gene ExpressionACSL5 [ NCBI-GEO ]   ACSL5 [ EBI - ARRAY_EXPRESS ]   ACSL5 [ SEEK ]   ACSL5 [ MEM ]
Gene Expression Viewer (FireBrowse)ACSL5 [ Firebrowse - Broad ]
GenevisibleExpression of ACSL5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51703
GTEX Portal (Tissue expression)ACSL5
Human Protein AtlasENSG00000197142-ACSL5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULC5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULC5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULC5
PhosPhoSitePlusQ9ULC5
Domaine pattern : Prosite (Expaxy)AMP_BINDING (PS00455)   
Domains : Interpro (EBI)AMP-binding_CS    AMP-dep_Synth/Lig    AMP-dep_Synthh-like_sf   
Domain families : Pfam (Sanger)AMP-binding (PF00501)   
Domain families : Pfam (NCBI)pfam00501   
Conserved Domain (NCBI)ACSL5
SuperfamilyQ9ULC5
AlphaFold pdb e-kbQ9ULC5   
Human Protein Atlas [tissue]ENSG00000197142-ACSL5 [tissue]
HPRD16139
Protein Interaction databases
DIP (DOE-UCLA)Q9ULC5
IntAct (EBI)Q9ULC5
BioGRIDACSL5
STRING (EMBL)ACSL5
ZODIACACSL5
Ontologies - Pathways
QuickGOQ9ULC5
Ontology : AmiGOlong-chain fatty acid metabolic process  long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  protein binding  ATP binding  nucleoplasm  nucleolus  mitochondrion  mitochondrion  mitochondrial outer membrane  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  lipid biosynthetic process  positive regulation of long-chain fatty acid import across plasma membrane  membrane  membrane  integral component of membrane  long-chain fatty-acyl-CoA biosynthetic process  long-chain fatty-acyl-CoA biosynthetic process  arachidonate-CoA ligase activity  arachidonate-CoA ligase activity  
Ontology : EGO-EBIlong-chain fatty acid metabolic process  long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  protein binding  ATP binding  nucleoplasm  nucleolus  mitochondrion  mitochondrion  mitochondrial outer membrane  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  lipid biosynthetic process  positive regulation of long-chain fatty acid import across plasma membrane  membrane  membrane  integral component of membrane  long-chain fatty-acyl-CoA biosynthetic process  long-chain fatty-acyl-CoA biosynthetic process  arachidonate-CoA ligase activity  arachidonate-CoA ligase activity  
Pathways : KEGGFatty acid degradation    PPAR signaling pathway    Peroxisome    Adipocytokine signaling pathway   
NDEx NetworkACSL5
Atlas of Cancer Signalling NetworkACSL5
Wikipedia pathwaysACSL5
Orthology - Evolution
OrthoDB51703
GeneTree (enSembl)ENSG00000197142
Phylogenetic Trees/Animal Genes : TreeFamACSL5
Homologs : HomoloGeneACSL5
Homology/Alignments : Family Browser (UCSC)ACSL5
Gene fusions - Rearrangements
Fusion : MitelmanB4GALT4/ACSL5 [3q13.32/10q25.2]  
Fusion : MitelmanZDHHC6/ACSL5 [10q25.2/10q25.2]  
Fusion : QuiverACSL5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACSL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACSL5
dbVarACSL5
ClinVarACSL5
MonarchACSL5
1000_GenomesACSL5 
Exome Variant ServerACSL5
GNOMAD BrowserENSG00000197142
Varsome BrowserACSL5
ACMGACSL5 variants
VarityQ9ULC5
Genomic Variants (DGV)ACSL5 [DGVbeta]
DECIPHERACSL5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACSL5 
Mutations
ICGC Data PortalACSL5 
TCGA Data PortalACSL5 
Broad Tumor PortalACSL5
OASIS PortalACSL5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACSL5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DACSL5
Mutations and Diseases : HGMDACSL5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaACSL5
DgiDB (Drug Gene Interaction Database)ACSL5
DoCM (Curated mutations)ACSL5
CIViC (Clinical Interpretations of Variants in Cancer)ACSL5
Cancer3DACSL5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605677   
Orphanet
DisGeNETACSL5
MedgenACSL5
Genetic Testing Registry ACSL5
NextProtQ9ULC5 [Medical]
GENETestsACSL5
Target ValidationACSL5
Huge Navigator ACSL5 [HugePedia]
ClinGenACSL5
Clinical trials, drugs, therapy
MyCancerGenomeACSL5
Protein Interactions : CTDACSL5
Pharm GKB GenePA27969
PharosQ9ULC5
Clinical trialACSL5
Miscellaneous
canSAR (ICR)ACSL5
HarmonizomeACSL5
DataMed IndexACSL5
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXACSL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:58:17 CEST 2021

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