ACSS2 (acyl-CoA synthetase short chain family member 2)

2007-04-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
ACAS2,ACECS,ACS,ACSA,AceCS1,dJ1161H23.1
FUSION GENES

Other Information

Locus ID:

NCBI: 55902
MIM: 605832
HGNC: 15814
Ensembl: ENSG00000131069

Variants:

dbSNP: 55902
ClinVar: 55902
TCGA: ENSG00000131069
COSMIC: ACSS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131069ENST00000253382Q9NR19
ENSG00000131069ENST00000360596Q9NR19
ENSG00000131069ENST00000473172C9JY31
ENSG00000131069ENST00000475459F8WDJ9
ENSG00000131069ENST00000477932F8WCJ4
ENSG00000131069ENST00000480274F8WC73
ENSG00000131069ENST00000480978B4DEH9
ENSG00000131069ENST00000481284F8WBQ7
ENSG00000131069ENST00000484354C9JXD9
ENSG00000131069ENST00000488172C9J7L5
ENSG00000131069ENST00000493805C9IYL0

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Pyruvate metabolismKEGGko00620
Propanoate metabolismKEGGko00640
Glycolysis / GluconeogenesisKEGGhsa00010
Pyruvate metabolismKEGGhsa00620
Propanoate metabolismKEGGhsa00640
Metabolic pathwaysKEGGhsa01100
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Ethanol oxidationREACTOMER-HSA-71384

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD28550509
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD21636554
PA448073ethanolChemicalClinicalAnnotationassociatedPD28550509
PA448803carboplatinChemicalClinicalAnnotationassociatedPD21636554
PA449014cisplatinChemicalClinicalAnnotationassociatedPD21636554
PA449383docetaxelChemicalClinicalAnnotationassociatedPD21636554
PA449748gemcitabineChemicalClinicalAnnotationassociatedPD21636554
PA450761paclitaxelChemicalClinicalAnnotationassociatedPD21636554

References

Pubmed IDYearTitleCitations
167880622006Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2.290
255258782014Acetate is a bioenergetic substrate for human glioblastoma and brain metastases.195
255848942015Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress.177
255258772014Acetate dependence of tumors.156
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
280998442017Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation.52
285526162017Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.41
196173232009The importance of acetyl coenzyme A synthetase for 11C-acetate uptake and cell survival in hepatocellular carcinoma.33
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
204160772010Identification of type 2 diabetes-associated combination of SNPs using support vector machine.26

Citation

Dessen P

ACSS2 (acyl-CoA synthetase short chain family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46903/acss2