Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ACTL6A (actin like 6A)

Identity

Alias (NCBI)ACTL6
ARPN-BETA
Arp4
BAF53A
INO80K
HGNC (Hugo) ACTL6A
HGNC Alias symbActl6
BAF53A
Arp4
Baf53a
INO80K
HGNC Alias nameBAF complex 53 kDa subunit
 BRG1-associated factor 53A
 actin-related protein 4
 INO80 complex subunit K
LocusID (NCBI) 86
Atlas_Id 52255
Location 3q26.33  [Link to chromosome band 3q26]
Location_base_pair Starts at 179562880 and ends at 179588405 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTL6A (3q26.33) / ACTL6A (3q26.33)ACTL6A (3q26.33) / ALG3 (3q27.1)ACTL6A (3q26.33) / XPC (3p25.1)
NDUFB5 (3q26.33) / ACTL6A (3q26.33)PPP3CA (4q24) / ACTL6A (3q26.33)YWHAZ (8q22.3) / ACTL6A (3q26.33)
ACTL6A 3q26.33 / ALG3 3q27.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ACTL6A   24124
Cards
Entrez_Gene (NCBI)ACTL6A    actin like 6A
AliasesACTL6; ARPN-BETA; Arp4; BAF53A; 
INO80K
GeneCards (Weizmann)ACTL6A
Ensembl hg19 (Hinxton)ENSG00000136518 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136518 [Gene_View]  ENSG00000136518 [Sequence]  chr3:179562880-179588405 [Contig_View]  ACTL6A [Vega]
ICGC DataPortalENSG00000136518
TCGA cBioPortalACTL6A
AceView (NCBI)ACTL6A
Genatlas (Paris)ACTL6A
SOURCE (Princeton)ACTL6A
Genetics Home Reference (NIH)ACTL6A
Genomic and cartography
GoldenPath hg38 (UCSC)ACTL6A  -     chr3:179562880-179588405 +  3q26.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACTL6A  -     3q26.33   [Description]    (hg19-Feb_2009)
GoldenPathACTL6A - 3q26.33 [CytoView hg19]  ACTL6A - 3q26.33 [CytoView hg38]
ImmunoBaseENSG00000136518
Genome Data Viewer NCBIACTL6A [Mapview hg19]  
OMIM604958   
Gene and transcription
Genbank (Entrez)AA256726 AB015907 AB060168 AB061315 AF041474
RefSeq transcript (Entrez)NM_004301 NM_177989 NM_178042
Consensus coding sequences : CCDS (NCBI)ACTL6A
Gene ExpressionACTL6A [ NCBI-GEO ]   ACTL6A [ EBI - ARRAY_EXPRESS ]   ACTL6A [ SEEK ]   ACTL6A [ MEM ]
Gene Expression Viewer (FireBrowse)ACTL6A [ Firebrowse - Broad ]
GenevisibleExpression of ACTL6A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)86
GTEX Portal (Tissue expression)ACTL6A
Human Protein AtlasENSG00000136518-ACTL6A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO96019   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO96019  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO96019
PhosPhoSitePlusO96019
Domaine pattern : Prosite (Expaxy)ACTINS_2 (PS00432)   
Domains : Interpro (EBI)Actin    Actin_CS    ATPase_NBD   
Domain families : Pfam (Sanger)Actin (PF00022)   
Domain families : Pfam (NCBI)pfam00022   
Domain families : Smart (EMBL)ACTIN (SM00268)  
Conserved Domain (NCBI)ACTL6A
PDB (RSDB)6LTJ   
PDB Europe6LTJ   
PDB (PDBSum)6LTJ   
PDB (IMB)6LTJ   
Structural Biology KnowledgeBase6LTJ   
SCOP (Structural Classification of Proteins)6LTJ   
CATH (Classification of proteins structures)6LTJ   
SuperfamilyO96019
AlphaFold pdb e-kbO96019   
Human Protein Atlas [tissue]ENSG00000136518-ACTL6A [tissue]
HPRD05389
Protein Interaction databases
DIP (DOE-UCLA)O96019
IntAct (EBI)O96019
BioGRIDACTL6A
STRING (EMBL)ACTL6A
ZODIACACTL6A
Ontologies - Pathways
QuickGOO96019
Ontology : AmiGOchromatin  blastocyst formation  neural retina development  chromatin binding  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  plasma membrane  DNA repair  DNA recombination  chromatin remodeling  chromatin remodeling  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  signal transduction  nervous system development  SWI/SNF complex  SWI/SNF complex  protein deubiquitination  spinal cord development  Ino80 complex  nucleosomal DNA binding  protein-containing complex  NuA4 histone acetyltransferase complex  NuA4 histone acetyltransferase complex  regulation of growth  ATP-dependent chromatin remodeling  ATP-dependent chromatin remodeling  histone H4 acetylation  histone H4 acetylation  histone H2A acetylation  positive regulation of transcription, DNA-templated  npBAF complex  npBAF complex  
Ontology : EGO-EBIchromatin  blastocyst formation  neural retina development  chromatin binding  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  plasma membrane  DNA repair  DNA recombination  chromatin remodeling  chromatin remodeling  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  signal transduction  nervous system development  SWI/SNF complex  SWI/SNF complex  protein deubiquitination  spinal cord development  Ino80 complex  nucleosomal DNA binding  protein-containing complex  NuA4 histone acetyltransferase complex  NuA4 histone acetyltransferase complex  regulation of growth  ATP-dependent chromatin remodeling  ATP-dependent chromatin remodeling  histone H4 acetylation  histone H4 acetylation  histone H2A acetylation  positive regulation of transcription, DNA-templated  npBAF complex  npBAF complex  
Pathways : BIOCARTAControl of Gene Expression by Vitamin D Receptor [Genes]   
NDEx NetworkACTL6A
Atlas of Cancer Signalling NetworkACTL6A
Wikipedia pathwaysACTL6A
Orthology - Evolution
OrthoDB86
GeneTree (enSembl)ENSG00000136518
Phylogenetic Trees/Animal Genes : TreeFamACTL6A
Homologs : HomoloGeneACTL6A
Homology/Alignments : Family Browser (UCSC)ACTL6A
Gene fusions - Rearrangements
Fusion : MitelmanACTL6A/ALG3 [3q26.33/3q27.1]  
Fusion : QuiverACTL6A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACTL6A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACTL6A
dbVarACTL6A
ClinVarACTL6A
MonarchACTL6A
1000_GenomesACTL6A 
Exome Variant ServerACTL6A
GNOMAD BrowserENSG00000136518
Varsome BrowserACTL6A
ACMGACTL6A variants
VarityO96019
Genomic Variants (DGV)ACTL6A [DGVbeta]
DECIPHERACTL6A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACTL6A 
Mutations
ICGC Data PortalACTL6A 
TCGA Data PortalACTL6A 
Broad Tumor PortalACTL6A
OASIS PortalACTL6A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACTL6A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DACTL6A
Mutations and Diseases : HGMDACTL6A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaACTL6A
DgiDB (Drug Gene Interaction Database)ACTL6A
DoCM (Curated mutations)ACTL6A
CIViC (Clinical Interpretations of Variants in Cancer)ACTL6A
Cancer3DACTL6A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604958   
Orphanet
DisGeNETACTL6A
MedgenACTL6A
Genetic Testing Registry ACTL6A
NextProtO96019 [Medical]
GENETestsACTL6A
Target ValidationACTL6A
Huge Navigator ACTL6A [HugePedia]
ClinGenACTL6A
Clinical trials, drugs, therapy
MyCancerGenomeACTL6A
Protein Interactions : CTDACTL6A
Pharm GKB GenePA134914203
PharosO96019
Clinical trialACTL6A
Miscellaneous
canSAR (ICR)ACTL6A
HarmonizomeACTL6A
DataMed IndexACTL6A
Probes
Litterature
PubMed159 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXACTL6A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 14:58:19 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.