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ACTR1A (ARP1 actin-related protein 1 homolog A, centractin alpha)

Identity

Alias_namesARP1 (actin-related protein 1
Alias_symbol (synonym)ARP1
Arp1A
Other aliasCTRN1
HGNC (Hugo) ACTR1A
LocusID (NCBI) 10121
Atlas_Id 563
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 104238986 and ends at 104262512 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACTR1A (10q24.32) / ACTR1A (10q24.32)ACTR1A (10q24.32) / MIPOL1 (14q13.3)ACTR1A (10q24.32) / OBFC1 (10q24.33)
ACTR1A (10q24.32) / SLC2A1 (1p34.2)ARL3 (10q24.32) / ACTR1A (10q24.32)BOC (3q13.2) / ACTR1A (10q24.32)
MIPOL1 (14q13.3) / ACTR1A (10q24.32)ACTR1A 10q24.32 / OBFC1 10q24.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACTR1A   167
Cards
Entrez_Gene (NCBI)ACTR1A  10121  ARP1 actin-related protein 1 homolog A, centractin alpha
AliasesARP1; Arp1A; CTRN1
GeneCards (Weizmann)ACTR1A
Ensembl hg19 (Hinxton)ENSG00000138107 [Gene_View]  chr10:104238986-104262512 [Contig_View]  ACTR1A [Vega]
Ensembl hg38 (Hinxton)ENSG00000138107 [Gene_View]  chr10:104238986-104262512 [Contig_View]  ACTR1A [Vega]
ICGC DataPortalENSG00000138107
TCGA cBioPortalACTR1A
AceView (NCBI)ACTR1A
Genatlas (Paris)ACTR1A
WikiGenes10121
SOURCE (Princeton)ACTR1A
Genetics Home Reference (NIH)ACTR1A
Genomic and cartography
GoldenPath hg19 (UCSC)ACTR1A  -     chr10:104238986-104262512 -  10q24.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ACTR1A  -     10q24.32   [Description]    (hg38-Dec_2013)
EnsemblACTR1A - 10q24.32 [CytoView hg19]  ACTR1A - 10q24.32 [CytoView hg38]
Mapping of homologs : NCBIACTR1A [Mapview hg19]  ACTR1A [Mapview hg38]
OMIM605143   
Gene and transcription
Genbank (Entrez)AK096085 AK297362 AK297620 AK302072 AK312506
RefSeq transcript (Entrez)NM_005736
RefSeq genomic (Entrez)NC_000010 NC_018921 NG_011901 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)ACTR1A
Cluster EST : UnigeneHs.153961 [ NCBI ]
CGAP (NCI)Hs.153961
Alternative Splicing GalleryENSG00000138107
Gene ExpressionACTR1A [ NCBI-GEO ]   ACTR1A [ EBI - ARRAY_EXPRESS ]   ACTR1A [ SEEK ]   ACTR1A [ MEM ]
Gene Expression Viewer (FireBrowse)ACTR1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10121
GTEX Portal (Tissue expression)ACTR1A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61163   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61163  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61163
Splice isoforms : SwissVarP61163
PhosPhoSitePlusP61163
Domaine pattern : Prosite (Expaxy)ACTINS_2 (PS00432)    ACTINS_ACT_LIKE (PS01132)   
Domains : Interpro (EBI)Actin    Actin/actin-like_CS    Actin_CS    Arp1   
Domain families : Pfam (Sanger)Actin (PF00022)   
Domain families : Pfam (NCBI)pfam00022   
Domain families : Smart (EMBL)ACTIN (SM00268)  
Conserved Domain (NCBI)ACTR1A
DMDM Disease mutations10121
Blocks (Seattle)ACTR1A
SuperfamilyP61163
Human Protein AtlasENSG00000138107
Peptide AtlasP61163
HPRD05507
IPIIPI00029468   IPI00908883   IPI01013552   IPI01013091   
Protein Interaction databases
DIP (DOE-UCLA)P61163
IntAct (EBI)P61163
FunCoupENSG00000138107
BioGRIDACTR1A
STRING (EMBL)ACTR1A
ZODIACACTR1A
Ontologies - Pathways
QuickGOP61163
Ontology : AmiGOG2/M transition of mitotic cell cycle  ATP binding  cytoplasm  centrosome  cytosol  dynactin complex  microtubule associated complex  microtubule cytoskeleton  vesicle-mediated transport  antigen processing and presentation of exogenous peptide antigen via MHC class II  myelin sheath  extracellular exosome  microtubule end  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  ATP binding  cytoplasm  centrosome  cytosol  dynactin complex  microtubule associated complex  microtubule cytoskeleton  vesicle-mediated transport  antigen processing and presentation of exogenous peptide antigen via MHC class II  myelin sheath  extracellular exosome  microtubule end  
NDEx NetworkACTR1A
Atlas of Cancer Signalling NetworkACTR1A
Wikipedia pathwaysACTR1A
Orthology - Evolution
OrthoDB10121
GeneTree (enSembl)ENSG00000138107
Phylogenetic Trees/Animal Genes : TreeFamACTR1A
HOVERGENP61163
HOGENOMP61163
Homologs : HomoloGeneACTR1A
Homology/Alignments : Family Browser (UCSC)ACTR1A
Gene fusions - Rearrangements
Fusion : MitelmanACTR1A/OBFC1 [10q24.32/10q24.33]  
Fusion: TCGAACTR1A 10q24.32 OBFC1 10q24.33 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACTR1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACTR1A
dbVarACTR1A
ClinVarACTR1A
1000_GenomesACTR1A 
Exome Variant ServerACTR1A
ExAC (Exome Aggregation Consortium)ACTR1A (select the gene name)
Genetic variants : HAPMAP10121
Genomic Variants (DGV)ACTR1A [DGVbeta]
DECIPHER (Syndromes)10:104238986-104262512  ENSG00000138107
CONAN: Copy Number AnalysisACTR1A 
Mutations
ICGC Data PortalACTR1A 
TCGA Data PortalACTR1A 
Broad Tumor PortalACTR1A
OASIS PortalACTR1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACTR1A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACTR1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ACTR1A
DgiDB (Drug Gene Interaction Database)ACTR1A
DoCM (Curated mutations)ACTR1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACTR1A (select a term)
intoGenACTR1A
Cancer3DACTR1A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605143   
Orphanet
MedgenACTR1A
Genetic Testing Registry ACTR1A
NextProtP61163 [Medical]
TSGene10121
GENETestsACTR1A
Huge Navigator ACTR1A [HugePedia]
snp3D : Map Gene to Disease10121
BioCentury BCIQACTR1A
ClinGenACTR1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10121
Chemical/Pharm GKB GenePA24486
Clinical trialACTR1A
Miscellaneous
canSAR (ICR)ACTR1A (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACTR1A
EVEXACTR1A
GoPubMedACTR1A
iHOPACTR1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:51:28 CEST 2017

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