ACTR2 (actin related protein 2)

2007-09-01  

Identity

HGNC
LOCATION
2p14
LOCUSID
ALIAS
ARP2
FUSION GENES

Other Information

Locus ID:

NCBI: 10097
MIM: 604221
HGNC: 169
Ensembl: ENSG00000138071

Variants:

dbSNP: 10097
ClinVar: 10097
TCGA: ENSG00000138071
COSMIC: ACTR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138071ENST00000260641P61160
ENSG00000138071ENST00000377982P61160
ENSG00000138071ENST00000471552A0A1B0GWH0
ENSG00000138071ENST00000476840A0A1B0GWD0
ENSG00000138071ENST00000542850F5H6T1

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
126728172003A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton.78
192626732009The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility.71
170854362007IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway.68
192861352009Host cell entry by apicomplexa parasites requires actin polymerization in the host cell.57
230517392012A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens.57
185160902008WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2.53
153856242004Inhibiting the Arp2/3 complex limits infection of both intracellular mature vaccinia virus and primate lentiviruses.42
164037312006Actin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex.41
154694332004Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication.38
187204012008Arp2 depletion inhibits sheet-like protrusions but not linear protrusions of fibroblasts and lymphocytes.36

Citation

Dessen P

ACTR2 (actin related protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49744/actr2