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ACTR2 (ARP2 actin related protein 2 homolog)

Identity

Alias_namesARP2 (actin-related protein 2, yeast) homolog
ARP2 actin-related protein 2 homolog (yeast)
Alias_symbol (synonym)ARP2
Other alias
HGNC (Hugo) ACTR2
LocusID (NCBI) 10097
Atlas_Id 49744
Location 2p14  [Link to chromosome band 2p14]
Location_base_pair Starts at 65227695 and ends at 65271256 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACTR2 (2p14) / ADAMTS2 (5q35.3)ACTR2 (2p14) / EIF4A2 (3q27.3)ACTR2 (2p14) / NFE2L2 (2q31.2)
ACTR2 (2p14) / TSGA10 (2q11.2)CAPN7 (3p25.1) / ACTR2 (2p14)RAF1 (3p25.2) / ACTR2 (2p14)
SPRED2 (2p14) / ACTR2 (2p14)TIA1 (2p13.3) / ACTR2 (2p14)ACTR2 2p14 / TSGA10 2q11.2
TIA1 2p13.3 / ACTR2 2p14

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACTR2   169
Cards
Entrez_Gene (NCBI)ACTR2  10097  ARP2 actin related protein 2 homolog
AliasesARP2
GeneCards (Weizmann)ACTR2
Ensembl hg19 (Hinxton)ENSG00000138071 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138071 [Gene_View]  chr2:65227695-65271256 [Contig_View]  ACTR2 [Vega]
ICGC DataPortalENSG00000138071
TCGA cBioPortalACTR2
AceView (NCBI)ACTR2
Genatlas (Paris)ACTR2
WikiGenes10097
SOURCE (Princeton)ACTR2
Genetics Home Reference (NIH)ACTR2
Genomic and cartography
GoldenPath hg38 (UCSC)ACTR2  -     chr2:65227695-65271256 +  2p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACTR2  -     2p14   [Description]    (hg19-Feb_2009)
EnsemblACTR2 - 2p14 [CytoView hg19]  ACTR2 - 2p14 [CytoView hg38]
Mapping of homologs : NCBIACTR2 [Mapview hg19]  ACTR2 [Mapview hg38]
OMIM604221   
Gene and transcription
Genbank (Entrez)AF006082 AK295157 AK301634 AK315205 AL049356
RefSeq transcript (Entrez)NM_001005386 NM_005722
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACTR2
Cluster EST : UnigeneHs.744913 [ NCBI ]
CGAP (NCI)Hs.744913
Alternative Splicing GalleryENSG00000138071
Gene ExpressionACTR2 [ NCBI-GEO ]   ACTR2 [ EBI - ARRAY_EXPRESS ]   ACTR2 [ SEEK ]   ACTR2 [ MEM ]
Gene Expression Viewer (FireBrowse)ACTR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10097
GTEX Portal (Tissue expression)ACTR2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61160   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61160  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61160
Splice isoforms : SwissVarP61160
PhosPhoSitePlusP61160
Domaine pattern : Prosite (Expaxy)ACTINS_ACT_LIKE (PS01132)   
Domains : Interpro (EBI)Actin    Actin/actin-like_CS    Arp2   
Domain families : Pfam (Sanger)Actin (PF00022)   
Domain families : Pfam (NCBI)pfam00022   
Domain families : Smart (EMBL)ACTIN (SM00268)  
Conserved Domain (NCBI)ACTR2
DMDM Disease mutations10097
Blocks (Seattle)ACTR2
SuperfamilyP61160
Human Protein AtlasENSG00000138071
Peptide AtlasP61160
HPRD05023
IPIIPI00005159   IPI00909247   IPI01014716   IPI00470573   
Protein Interaction databases
DIP (DOE-UCLA)P61160
IntAct (EBI)P61160
FunCoupENSG00000138071
BioGRIDACTR2
STRING (EMBL)ACTR2
ZODIACACTR2
Ontologies - Pathways
QuickGOP61160
Ontology : AmiGOstructural constituent of cytoskeleton  ATP binding  extracellular region  cytoplasm  cytosol  Arp2/3 protein complex  Arp2/3 protein complex  focal adhesion  movement of cell or subcellular component  establishment or maintenance of cell polarity  associative learning  asymmetric cell division  postsynaptic density  actin cytoskeleton  membrane  meiotic chromosome movement towards spindle pole  cytosolic transport  lamellipodium  actin cap  meiotic cytokinesis  Arp2/3 complex-mediated actin nucleation  azurophil granule lumen  response to immobilization stress  cellular response to trichostatin A  Fc-gamma receptor signaling pathway involved in phagocytosis  neutrophil degranulation  response to ethanol  ephrin receptor signaling pathway  actin filament binding  spindle localization  cilium assembly  positive regulation of dendritic spine morphogenesis  membrane organization  podosome core  extracellular exosome  invadopodium  ficolin-1-rich granule lumen  
Ontology : EGO-EBIstructural constituent of cytoskeleton  ATP binding  extracellular region  cytoplasm  cytosol  Arp2/3 protein complex  Arp2/3 protein complex  focal adhesion  movement of cell or subcellular component  establishment or maintenance of cell polarity  associative learning  asymmetric cell division  postsynaptic density  actin cytoskeleton  membrane  meiotic chromosome movement towards spindle pole  cytosolic transport  lamellipodium  actin cap  meiotic cytokinesis  Arp2/3 complex-mediated actin nucleation  azurophil granule lumen  response to immobilization stress  cellular response to trichostatin A  Fc-gamma receptor signaling pathway involved in phagocytosis  neutrophil degranulation  response to ethanol  ephrin receptor signaling pathway  actin filament binding  spindle localization  cilium assembly  positive regulation of dendritic spine morphogenesis  membrane organization  podosome core  extracellular exosome  invadopodium  ficolin-1-rich granule lumen  
NDEx NetworkACTR2
Atlas of Cancer Signalling NetworkACTR2
Wikipedia pathwaysACTR2
Orthology - Evolution
OrthoDB10097
GeneTree (enSembl)ENSG00000138071
Phylogenetic Trees/Animal Genes : TreeFamACTR2
HOVERGENP61160
HOGENOMP61160
Homologs : HomoloGeneACTR2
Homology/Alignments : Family Browser (UCSC)ACTR2
Gene fusions - Rearrangements
Fusion : MitelmanACTR2/TSGA10 [2p14/2q11.2]  
Fusion : MitelmanTIA1/ACTR2 [2p13.3/2p14]  [t(2;2)(p13;p14)]  
Fusion: TCGAACTR2 2p14 TSGA10 2q11.2 LUSC
Fusion: TCGATIA1 2p13.3 ACTR2 2p14 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACTR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACTR2
dbVarACTR2
ClinVarACTR2
1000_GenomesACTR2 
Exome Variant ServerACTR2
ExAC (Exome Aggregation Consortium)ACTR2 (select the gene name)
Genetic variants : HAPMAP10097
Genomic Variants (DGV)ACTR2 [DGVbeta]
DECIPHERACTR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACTR2 
Mutations
ICGC Data PortalACTR2 
TCGA Data PortalACTR2 
Broad Tumor PortalACTR2
OASIS PortalACTR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACTR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACTR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ACTR2
DgiDB (Drug Gene Interaction Database)ACTR2
DoCM (Curated mutations)ACTR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACTR2 (select a term)
intoGenACTR2
Cancer3DACTR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604221   
Orphanet
MedgenACTR2
Genetic Testing Registry ACTR2
NextProtP61160 [Medical]
TSGene10097
GENETestsACTR2
Target ValidationACTR2
Huge Navigator ACTR2 [HugePedia]
snp3D : Map Gene to Disease10097
BioCentury BCIQACTR2
ClinGenACTR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10097
Chemical/Pharm GKB GenePA24488
Clinical trialACTR2
Miscellaneous
canSAR (ICR)ACTR2 (select the gene name)
Probes
Litterature
PubMed114 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACTR2
EVEXACTR2
GoPubMedACTR2
iHOPACTR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:22:38 CEST 2017

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