ACTR3 (actin related protein 3)

2007-02-01  

Identity

HGNC
ACTR3
LOCATION
2q14.1
LOCUSID
10096
ALIAS
ARP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10096
MIM: 604222
HGNC: 170
Ensembl: ENSG00000115091

Variants:

dbSNP: 10096
ClinVar: 10096
TCGA: ENSG00000115091
COSMIC: ACTR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115091ENST00000263238P61158
ENSG00000115091ENST00000263238A0A024RAI1
ENSG00000115091ENST00000415792F8WEW2
ENSG00000115091ENST00000443297F8WDR7
ENSG00000115091ENST00000446821F8WE84
ENSG00000115091ENST00000535589B4DXW1

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
126728172003A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton.78
192626732009The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility.71
170854362007IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway.68
192861352009Host cell entry by apicomplexa parasites requires actin polymerization in the host cell.57
230517392012A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens.57
185160902008WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2.53
175769292007p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin.48
153856242004Inhibiting the Arp2/3 complex limits infection of both intracellular mature vaccinia virus and primate lentiviruses.42
164037312006Actin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex.41
154694332004Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication.38

Citation

Dessen P

ACTR3 (actin related protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46303/actr3