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ACTR3 (ARP3 actin related protein 3 homolog)

Identity

Alias_namesARP3 (actin-related protein 3, yeast) homolog
ARP3 actin-related protein 3 homolog (yeast)
Alias_symbol (synonym)ARP3
Other alias
HGNC (Hugo) ACTR3
LocusID (NCBI) 10096
Atlas_Id 46303
Location 2q14.1  [Link to chromosome band 2q14]
Location_base_pair Starts at 113890598 and ends at 113961552 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTR3 (2q14.1) / ABT1 (6p22.2)ACTR3 (2q14.1) / ALB (4q13.3)ACTR3 (2q14.1) / KDM3A (2p11.2)
ACTR3 (2q14.1) / RPS6KA3 (Xp22.12)ACTR3 (2q14.1) / XIST (Xq13.2)RPS6KA3 (Xp22.12) / ACTR3 (2q14.1)
SLC38A1 (12q13.11) / ACTR3 (2q14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACTR3   170
Cards
Entrez_Gene (NCBI)ACTR3  10096  ARP3 actin related protein 3 homolog
AliasesARP3
GeneCards (Weizmann)ACTR3
Ensembl hg19 (Hinxton)ENSG00000115091 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115091 [Gene_View]  chr2:113890598-113961552 [Contig_View]  ACTR3 [Vega]
ICGC DataPortalENSG00000115091
TCGA cBioPortalACTR3
AceView (NCBI)ACTR3
Genatlas (Paris)ACTR3
WikiGenes10096
SOURCE (Princeton)ACTR3
Genetics Home Reference (NIH)ACTR3
Genomic and cartography
GoldenPath hg38 (UCSC)ACTR3  -     chr2:113890598-113961552 +  2q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACTR3  -     2q14.1   [Description]    (hg19-Feb_2009)
EnsemblACTR3 - 2q14.1 [CytoView hg19]  ACTR3 - 2q14.1 [CytoView hg38]
Mapping of homologs : NCBIACTR3 [Mapview hg19]  ACTR3 [Mapview hg38]
OMIM604222   
Gene and transcription
Genbank (Entrez)AB209353 AF006083 AF127773 AI521063 AK300030
RefSeq transcript (Entrez)NM_001277140 NM_005721
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACTR3
Cluster EST : UnigeneHs.595349 [ NCBI ]
CGAP (NCI)Hs.595349
Alternative Splicing GalleryENSG00000115091
Gene ExpressionACTR3 [ NCBI-GEO ]   ACTR3 [ EBI - ARRAY_EXPRESS ]   ACTR3 [ SEEK ]   ACTR3 [ MEM ]
Gene Expression Viewer (FireBrowse)ACTR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10096
GTEX Portal (Tissue expression)ACTR3
Human Protein AtlasENSG00000115091-ACTR3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61158   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61158  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61158
Splice isoforms : SwissVarP61158
PhosPhoSitePlusP61158
Domaine pattern : Prosite (Expaxy)ACTINS_ACT_LIKE (PS01132)   
Domains : Interpro (EBI)Actin    Actin/actin-like_CS    Arp3_met   
Domain families : Pfam (Sanger)Actin (PF00022)   
Domain families : Pfam (NCBI)pfam00022   
Domain families : Smart (EMBL)ACTIN (SM00268)  
Conserved Domain (NCBI)ACTR3
DMDM Disease mutations10096
Blocks (Seattle)ACTR3
SuperfamilyP61158
Human Protein Atlas [tissue]ENSG00000115091-ACTR3 [tissue]
Peptide AtlasP61158
HPRD05024
IPIIPI00028091   IPI01012480   IPI01012955   IPI01013413   IPI00917422   IPI00916399   IPI00916540   
Protein Interaction databases
DIP (DOE-UCLA)P61158
IntAct (EBI)P61158
FunCoupENSG00000115091
BioGRIDACTR3
STRING (EMBL)ACTR3
ZODIACACTR3
Ontologies - Pathways
QuickGOP61158
Ontology : AmiGOstructural constituent of cytoskeleton  protein binding  ATP binding  cytosol  Arp2/3 protein complex  Arp2/3 protein complex  brush border  cell-cell junction  focal adhesion  movement of cell or subcellular component  establishment or maintenance of cell polarity  asymmetric cell division  actin cytoskeleton  membrane  meiotic chromosome movement towards spindle pole  lamellipodium  meiotic cytokinesis  Arp2/3 complex-mediated actin nucleation  Fc-gamma receptor signaling pathway involved in phagocytosis  ephrin receptor signaling pathway  actin filament binding  spindle localization  cilium assembly  membrane organization  extracellular exosome  
Ontology : EGO-EBIstructural constituent of cytoskeleton  protein binding  ATP binding  cytosol  Arp2/3 protein complex  Arp2/3 protein complex  brush border  cell-cell junction  focal adhesion  movement of cell or subcellular component  establishment or maintenance of cell polarity  asymmetric cell division  actin cytoskeleton  membrane  meiotic chromosome movement towards spindle pole  lamellipodium  meiotic cytokinesis  Arp2/3 complex-mediated actin nucleation  Fc-gamma receptor signaling pathway involved in phagocytosis  ephrin receptor signaling pathway  actin filament binding  spindle localization  cilium assembly  membrane organization  extracellular exosome  
NDEx NetworkACTR3
Atlas of Cancer Signalling NetworkACTR3
Wikipedia pathwaysACTR3
Orthology - Evolution
OrthoDB10096
GeneTree (enSembl)ENSG00000115091
Phylogenetic Trees/Animal Genes : TreeFamACTR3
HOVERGENP61158
HOGENOMP61158
Homologs : HomoloGeneACTR3
Homology/Alignments : Family Browser (UCSC)ACTR3
Gene fusions - Rearrangements
Fusion: Tumor Portal ACTR3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACTR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACTR3
dbVarACTR3
ClinVarACTR3
1000_GenomesACTR3 
Exome Variant ServerACTR3
ExAC (Exome Aggregation Consortium)ENSG00000115091
GNOMAD BrowserENSG00000115091
Genetic variants : HAPMAP10096
Genomic Variants (DGV)ACTR3 [DGVbeta]
DECIPHERACTR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACTR3 
Mutations
ICGC Data PortalACTR3 
TCGA Data PortalACTR3 
Broad Tumor PortalACTR3
OASIS PortalACTR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACTR3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACTR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ACTR3
DgiDB (Drug Gene Interaction Database)ACTR3
DoCM (Curated mutations)ACTR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACTR3 (select a term)
intoGenACTR3
Cancer3DACTR3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604222   
Orphanet
MedgenACTR3
Genetic Testing Registry ACTR3
NextProtP61158 [Medical]
TSGene10096
GENETestsACTR3
Target ValidationACTR3
Huge Navigator ACTR3 [HugePedia]
snp3D : Map Gene to Disease10096
BioCentury BCIQACTR3
ClinGenACTR3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10096
Chemical/Pharm GKB GenePA24489
Clinical trialACTR3
Miscellaneous
canSAR (ICR)ACTR3 (select the gene name)
Probes
Litterature
PubMed105 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACTR3
EVEXACTR3
GoPubMedACTR3
iHOPACTR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:39:06 CET 2017

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