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ACTR3B (actin related protein 3B)

Identity

Alias (NCBI)ARP11
ARP3BETA
HGNC (Hugo) ACTR3B
HGNC Alias symbARP11
ARP3beta
HGNC Previous nameARP3 actin-related protein 3 homolog B (yeast)
 ARP3 actin related protein 3 homolog B
LocusID (NCBI) 57180
Atlas_Id 43664
Location 7q36.1  [Link to chromosome band 7q36]
Location_base_pair Starts at 152759752 and ends at 152855378 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTR3B (7q36.1)::PTPRN2 (7q36.3)FOXP1 (3p13)::ACTR3B (7q36.1)KMT2C (7q36.1)::ACTR3B (7q36.1)
FOXP1 3p13::ACTR3B 7q36.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(7;7)(q36;q36) KMT2C::ACTR3B


External links

 

Nomenclature
HGNC (Hugo)ACTR3B   17256
Cards
Entrez_Gene (NCBI)ACTR3B    actin related protein 3B
AliasesARP11; ARP3BETA
GeneCards (Weizmann)ACTR3B
Ensembl hg19 (Hinxton)ENSG00000133627 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133627 [Gene_View]  ENSG00000133627 [Sequence]  chr7:152759752-152855378 [Contig_View]  ACTR3B [Vega]
ICGC DataPortalENSG00000133627
TCGA cBioPortalACTR3B
AceView (NCBI)ACTR3B
Genatlas (Paris)ACTR3B
SOURCE (Princeton)ACTR3B
Genetics Home Reference (NIH)ACTR3B
Genomic and cartography
GoldenPath hg38 (UCSC)ACTR3B  -     chr7:152759752-152855378 +  7q36.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACTR3B  -     7q36.1   [Description]    (hg19-Feb_2009)
GoldenPathACTR3B - 7q36.1 [CytoView hg19]  ACTR3B - 7q36.1 [CytoView hg38]
ImmunoBaseENSG00000133627
Genome Data Viewer NCBIACTR3B [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AA559050 AB209174 AF023453 AF086920 AK001198
RefSeq transcript (Entrez)NM_001040135 NM_001350940 NM_001350941 NM_001350942 NM_001350943 NM_001350944 NM_001350945 NM_001350946 NM_020445
Consensus coding sequences : CCDS (NCBI)ACTR3B
Gene ExpressionACTR3B [ NCBI-GEO ]   ACTR3B [ EBI - ARRAY_EXPRESS ]   ACTR3B [ SEEK ]   ACTR3B [ MEM ]
Gene Expression Viewer (FireBrowse)ACTR3B [ Firebrowse - Broad ]
GenevisibleExpression of ACTR3B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57180
GTEX Portal (Tissue expression)ACTR3B
Human Protein AtlasENSG00000133627-ACTR3B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P1U1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P1U1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P1U1
PhosPhoSitePlusQ9P1U1
Domaine pattern : Prosite (Expaxy)ACTINS_ACT_LIKE (PS01132)   
Domains : Interpro (EBI)Actin    Actin/actin-like_CS    ATPase_NBD   
Domain families : Pfam (Sanger)Actin (PF00022)   
Domain families : Pfam (NCBI)pfam00022   
Domain families : Smart (EMBL)ACTIN (SM00268)  
Conserved Domain (NCBI)ACTR3B
SuperfamilyQ9P1U1
AlphaFold pdb e-kbQ9P1U1   
Human Protein Atlas [tissue]ENSG00000133627-ACTR3B [tissue]
HPRD12489
Protein Interaction databases
DIP (DOE-UCLA)Q9P1U1
IntAct (EBI)Q9P1U1
BioGRIDACTR3B
STRING (EMBL)ACTR3B
ZODIACACTR3B
Ontologies - Pathways
QuickGOQ9P1U1
Ontology : AmiGOmolecular_function  ATP binding  cytoplasm  cytoskeleton  biological_process  cell projection  actin filament binding  extracellular exosome  
Ontology : EGO-EBImolecular_function  ATP binding  cytoplasm  cytoskeleton  biological_process  cell projection  actin filament binding  extracellular exosome  
NDEx NetworkACTR3B
Atlas of Cancer Signalling NetworkACTR3B
Wikipedia pathwaysACTR3B
Orthology - Evolution
OrthoDB57180
GeneTree (enSembl)ENSG00000133627
Phylogenetic Trees/Animal Genes : TreeFamACTR3B
Homologs : HomoloGeneACTR3B
Homology/Alignments : Family Browser (UCSC)ACTR3B
Gene fusions - Rearrangements
Fusion : MitelmanACTR3B::PTPRN2 [7q36.1/7q36.3]  
Fusion : MitelmanFOXP1::ACTR3B [3p13/7q36.1]  
Fusion : MitelmanKMT2C::ACTR3B [7q36.1/7q36.1]  
Fusion : QuiverACTR3B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACTR3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACTR3B
dbVarACTR3B
ClinVarACTR3B
MonarchACTR3B
1000_GenomesACTR3B 
Exome Variant ServerACTR3B
GNOMAD BrowserENSG00000133627
Varsome BrowserACTR3B
ACMGACTR3B variants
VarityQ9P1U1
Genomic Variants (DGV)ACTR3B [DGVbeta]
DECIPHERACTR3B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACTR3B 
Mutations
ICGC Data PortalACTR3B 
TCGA Data PortalACTR3B 
Broad Tumor PortalACTR3B
OASIS PortalACTR3B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACTR3B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DACTR3B
Mutations and Diseases : HGMDACTR3B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaACTR3B
DgiDB (Drug Gene Interaction Database)ACTR3B
DoCM (Curated mutations)ACTR3B
CIViC (Clinical Interpretations of Variants in Cancer)ACTR3B
Cancer3DACTR3B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETACTR3B
MedgenACTR3B
Genetic Testing Registry ACTR3B
NextProtQ9P1U1 [Medical]
GENETestsACTR3B
Target ValidationACTR3B
Huge Navigator ACTR3B [HugePedia]
ClinGenACTR3B
Clinical trials, drugs, therapy
MyCancerGenomeACTR3B
Protein Interactions : CTDACTR3B
Pharm GKB GenePA142672645
PharosQ9P1U1
Clinical trialACTR3B
Miscellaneous
canSAR (ICR)ACTR3B
HarmonizomeACTR3B
ARCHS4ACTR3B
DataMed IndexACTR3B
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXACTR3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:21:15 CET 2022

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