| Nomenclature | | HGNC (Hugo) | ACVR1B 172 |
| Entrez_Gene (NCBI) | ACVR1B 91 activin A receptor, type IB |
| Cards | | GeneCards (Weizmann) | ACVR1B |
| Ensembl (Hinxton) | ENSG00000135503 [Gene_View] chr12:52345451-52390863 [Contig_View] ACVR1B [Vega] |
| AceView (NCBI) | ACVR1B |
| Genatlas (Paris) | ACVR1B |
| SOURCE (Stanford) | NM_004302 NM_020327 NM_020328 |
| Genomic and cartography | | GoldenPath (UCSC) | ACVR1B - 12q13.13 chr12:52345451-52390863 + 12q13.13 [Description] (hg19-Feb_2009) |
| Ensembl | ACVR1B - 12q13.13 [CytoView] |
| Mapping of homologs : NCBI | ACVR1B [Mapview] |
| OMIM | 601300 |
| Gene and transcription |
| Genbank (Entrez) | AK299120 AK299496 AL117643 BC000254 BC034008 |
| RefSeq transcript (SRS) | NM_004302 NM_020327 NM_020328 |
| RefSeq transcript (Entrez) | NM_004302 NM_020327 NM_020328 |
| RefSeq genomic (SRS) | AC_000144 NC_000012 NC_018923 NG_022926 NT_029419 NW_001838057 NW_004078075 |
| RefSeq genomic (Entrez) | AC_000144 NC_000012 NC_018923 NG_022926 NT_029419 NW_001838057 NW_004078075 |
| Consensus coding sequences : CCDS (NCBI) | ACVR1B |
| Cluster EST : Unigene | Hs.438918 [ SRS ] Hs.438918 [ NCBI ] |
| CGAP (NCI) | Hs.438918 |
| Alternative Splicing : Fast-db (Paris) | GSHG0006671 |
| Alternative Splicing Gallery | ENSG00000135503 |
| Gene Expression | ACVR1B [ NCBI-GEO ] ACVR1B [ EBI - ARRAY_EXPRESS ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P36896 (SRS) P36896 (Uniprot) |
| NextProt | P36896 |
| With graphics : InterPro | P36896 |
| Splice isoforms : SwissVar | P36896(Swissvar) |
| Domaine pattern : Prosite (SRS) | GS (PS51256) PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) |
| Domaine pattern : Prosite (Expaxy) | GS (PS51256) PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) |
| Domains : Interpro (SRS) | Activin_rcpt Kinase-like_dom Prot_kinase_cat_dom Protein_kinase_ATP_BS Ser/Thr_kinase_AS TGF_beta_rcpt_GS |
| Domains : Interpro (EBI) | Activin_rcpt Kinase-like_dom Prot_kinase_cat_dom Protein_kinase_ATP_BS Ser/Thr_kinase_AS TGF_beta_rcpt_GS |
| Related proteins : CluSTr | P36896 |
| Domain families : Pfam (SRS) | Activin_recp (PF01064) Pkinase (PF00069) TGF_beta_GS (PF08515) |
| Domain families : Pfam (Sanger) | Activin_recp (PF01064) Pkinase (PF00069) TGF_beta_GS (PF08515) |
| Domain families : Pfam (NCBI) | pfam01064 pfam00069 pfam08515 |
| Domain families : Smart (EMBL) | GS (SM00467) |
| DMDM | 91 |
| Blocks (Seattle) | P36896 |
| Human Protein Atlas | ENSG00000135503 |
| HPRD | 03193 |
| IPI | IPI00005732 IPI00218980 IPI00297220 IPI00922639 IPI01014752 IPI00793921 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P36896 |
| IntAct (EBI) | P36896 |
| FunCoup | ENSG00000135503 |
| REACTOME | ACVR1B |
| Protein Interaction Database | 91 |
| BioGRID | ACVR1B |
| InParanoid | P36896 |
| Interologous Interaction database | P36896 |
| IntegromeDB | ACVR1B |
| Polymorphism : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | ACVR1B |
| SNP (GeneSNP Utah) | ACVR1B |
| SNP : HGBase | ACVR1B |
| Genetic variants : HAPMAP | ACVR1B |
| Somatic Mutations in Cancer : COSMIC | ACVR1B |
| CONAN: Copy Number Analysis | ACVR1B |
| Mutations and Diseases : HGMD | ACVR1B |
| OMIM | 601300 |
| GENETests | 601300 |
| Disease Genetic Association | ACVR1B |
| Huge Navigator |
ACVR1B [HugePedia] ACVR1B [HugeCancerGEM] |
| Genomic Variants | ACVR1B ACVR1B [DGVbeta] |
| ClinVar | ACVR1B |
| snp3D : Map Gene to Disease | 91 |
| General knowledge |
|---|
| Homologs : HomoloGene | ACVR1B |
| Homology/Alignments : Family Browser (UCSC) | ACVR1B |
| Phylogenetic Trees/Animal Genes : TreeFam | ACVR1B |
| Catalytic activity : Enzyme | 2.7.11.30 [ Enzyme-Expasy ] 2.7.11.30 [ Enzyme-SRS ] 2.7.11.30 [ IntEnz-EBI ] 2.7.11.30 [ BRENDA ] 2.7.11.30 [ KEGG ] |
| Chemical/Protein Interactions : CTD | 91 |
| Chemical/Pharm GKB Gene | PA24493 |
| Clinical trial | ACVR1B |
| Cancer Resource (Charite) | ENSG00000135503 |
| Ontology : AmiGO | G1/S transition of mitotic cell cycle in utero embryonic development hair follicle development protein serine/threonine kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity protein binding ATP binding plasma membrane integral to plasma membrane regulation of transcription, DNA-dependent protein phosphorylation induction of apoptosis signal transduction transmembrane receptor protein serine/threonine kinase signaling pathway central nervous system development cell surface positive regulation of pathway-restricted SMAD protein phosphorylation activin receptor activity, type I activin receptor activity, type I activin-activated receptor activity peptidyl-threonine phosphorylation growth factor binding negative regulation of cell growth ubiquitin protein ligase binding activin receptor signaling pathway positive regulation of activin receptor signaling pathway positive regulation of activin receptor signaling pathway inhibin binding nodal signaling pathway positive regulation of erythrocyte differentiation positive regulation of transcription from RNA polymerase II promoter SMAD binding development of primary female sexual characteristics protein autophosphorylation metal ion binding activin binding positive regulation of trophoblast cell migration |
| Ontology : EGO-EBI | G1/S transition of mitotic cell cycle in utero embryonic development hair follicle development protein serine/threonine kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity protein binding ATP binding plasma membrane integral to plasma membrane regulation of transcription, DNA-dependent protein phosphorylation induction of apoptosis signal transduction transmembrane receptor protein serine/threonine kinase signaling pathway central nervous system development cell surface positive regulation of pathway-restricted SMAD protein phosphorylation activin receptor activity, type I activin receptor activity, type I activin-activated receptor activity peptidyl-threonine phosphorylation growth factor binding negative regulation of cell growth ubiquitin protein ligase binding activin receptor signaling pathway positive regulation of activin receptor signaling pathway positive regulation of activin receptor signaling pathway inhibin binding nodal signaling pathway positive regulation of erythrocyte differentiation positive regulation of transcription from RNA polymerase II promoter SMAD binding development of primary female sexual characteristics protein autophosphorylation metal ion binding activin binding positive regulation of trophoblast cell migration |
| Pathways : KEGG | Colorectal cancerTGF-beta signaling pathwayMAPK signaling pathwayCytokine-cytokine receptor interactionAdherens junction |
| Other databases | | Probes |
|---|
| Litterature | | PubMed | 61 Pubmed reference(s) in Entrez |
| PubGene | ACVR1B |
| iHOP | ACVR1B |
