Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ACVR2B (activin A receptor, type IIB)

Identity

Other namesACTRIIB
ActR-IIB
HTX4
HGNC (Hugo) ACVR2B
LocusID (NCBI) 93
Location 3p22.2
Location_base_pair Starts at 38495790 and ends at 38534633 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ACVR2B   174
Cards
Entrez_Gene (NCBI)ACVR2B  93  activin A receptor, type IIB
GeneCards (Weizmann)ACVR2B
Ensembl (Hinxton) [Gene_View]  chr3:38495790-38534633 [Contig_View]  ACVR2B [Vega]
AceView (NCBI)ACVR2B
Genatlas (Paris)ACVR2B
WikiGenes93
SOURCE (Princeton)NM_001106
Genomic and cartography
GoldenPath (UCSC)ACVR2B  -  3p22.2   chr3:38495790-38534633 +  3p22.2   [Description]    (hg19-Feb_2009)
EnsemblACVR2B - 3p22.2 [CytoView]
Mapping of homologs : NCBIACVR2B [Mapview]
OMIM602730   613751   
Gene and transcription
Genbank (Entrez)AB209449 AF075005 BC096243 BC096244 BC096245
RefSeq transcript (Entrez)NM_001106
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_011791 NT_022517 NW_001838877 NW_004929309
Consensus coding sequences : CCDS (NCBI)ACVR2B
Cluster EST : UnigeneHs.174273 [ NCBI ]
CGAP (NCI)Hs.174273
Alternative Splicing : Fast-db (Paris)GSHG0020706
Gene ExpressionACVR2B [ NCBI-GEO ]     ACVR2B [ SEEK ]   ACVR2B [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13705 (Uniprot)
NextProtQ13705  [Medical]
With graphics : InterProQ13705
Splice isoforms : SwissVarQ13705 (Swissvar)
Catalytic activity : Enzyme2.7.11.30 [ Enzyme-Expasy ]   2.7.11.302.7.11.30 [ IntEnz-EBI ]   2.7.11.30 [ BRENDA ]   2.7.11.30 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Activin_rcpt    Kinase-like_dom    Prot_kinase_dom    Ser/Thr_kinase_AS    TGFB_receptor   
Related proteins : CluSTrQ13705
Domain families : Pfam (Sanger)Activin_recp (PF01064)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam01064    pfam00069   
DMDM Disease mutations93
Blocks (Seattle)Q13705
PDB (SRS)2H62    2QLU    4FAO   
PDB (PDBSum)2H62    2QLU    4FAO   
PDB (IMB)2H62    2QLU    4FAO   
PDB (RSDB)2H62    2QLU    4FAO   
Peptide AtlasQ13705
HPRD04106
IPIIPI00437565   
Protein Interaction databases
DIP (DOE-UCLA)Q13705
IntAct (EBI)Q13705
BioGRIDACVR2B
InParanoidQ13705
Interologous Interaction database Q13705
IntegromeDBACVR2B
STRING (EMBL)ACVR2B
Ontologies - Pathways
Ontology : AmiGOgastrulation with mouth forming second  kidney development  lymphangiogenesis  blood vessel remodeling  protein serine/threonine kinase activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  transforming growth factor beta-activated receptor activity  protein binding  ATP binding  cytoplasm  plasma membrane  integral to plasma membrane  regulation of transcription, DNA-dependent  signal transduction  transmembrane receptor protein serine/threonine kinase signaling pathway  determination of left/right symmetry  mesoderm development  heart development  response to glucose  post-embryonic development  anterior/posterior pattern specification  cell surface  activin receptor activity, type II  growth factor binding  insulin secretion  lung development  positive regulation of bone mineralization  BMP signaling pathway  BMP signaling pathway  BMP signaling pathway  pancreas development  activation of protein kinase activity  positive regulation of activin receptor signaling pathway  inhibin binding  organ growth  odontogenesis of dentin-containing tooth  positive regulation of osteoblast differentiation  metal ion binding  activin binding  embryonic foregut morphogenesis  skeletal system morphogenesis  palate development  lymphatic endothelial cell differentiation  artery development  venous blood vessel development  retina vasculature development in camera-type eye  
Ontology : EGO-EBIgastrulation with mouth forming second  kidney development  lymphangiogenesis  blood vessel remodeling  protein serine/threonine kinase activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  transforming growth factor beta-activated receptor activity  protein binding  ATP binding  cytoplasm  plasma membrane  integral to plasma membrane  regulation of transcription, DNA-dependent  signal transduction  transmembrane receptor protein serine/threonine kinase signaling pathway  determination of left/right symmetry  mesoderm development  heart development  response to glucose  post-embryonic development  anterior/posterior pattern specification  cell surface  activin receptor activity, type II  growth factor binding  insulin secretion  lung development  positive regulation of bone mineralization  BMP signaling pathway  BMP signaling pathway  BMP signaling pathway  pancreas development  activation of protein kinase activity  positive regulation of activin receptor signaling pathway  inhibin binding  organ growth  odontogenesis of dentin-containing tooth  positive regulation of osteoblast differentiation  metal ion binding  activin binding  embryonic foregut morphogenesis  skeletal system morphogenesis  palate development  lymphatic endothelial cell differentiation  artery development  venous blood vessel development  retina vasculature development in camera-type eye  
Pathways : KEGGCytokine-cytokine receptor interaction    TGF-beta signaling pathway   
REACTOMEACVR2B
Protein Interaction DatabaseACVR2B
Wikipedia pathwaysACVR2B
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ACVR2B
SNP (GeneSNP Utah)ACVR2B
SNP : HGBaseACVR2B
Genetic variants : HAPMAPACVR2B
1000_GenomesACVR2B 
Somatic Mutations in Cancer : COSMICACVR2B 
CONAN: Copy Number AnalysisACVR2B 
Mutations and Diseases : HGMDACVR2B
OMIM602730    613751   
GENETestsACVR2B
Disease Genetic AssociationACVR2B
Huge Navigator ACVR2B [HugePedia]  ACVR2B [HugeCancerGEM]
Genomic VariantsACVR2B  ACVR2B [DGVbeta]
Exome VariantACVR2B
dbVarACVR2B
ClinVarACVR2B
snp3D : Map Gene to Disease93
General knowledge
Homologs : HomoloGeneACVR2B
Homology/Alignments : Family Browser (UCSC)ACVR2B
Phylogenetic Trees/Animal Genes : TreeFamACVR2B
Chemical/Protein Interactions : CTD93
Chemical/Pharm GKB GenePA24495
Clinical trialACVR2B
Other databases
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
CoreMineACVR2B
iHOPACVR2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 16:59:45 CEST 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.