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ACY1 (aminoacylase 1)

Identity

Other aliasACY-1
ACY1D
HEL-S-5
HGNC (Hugo) ACY1
LocusID (NCBI) 95
Atlas_Id 570
Location 3p21.2  [Link to chromosome band 3p21]
Location_base_pair Starts at 51983284 and ends at 51989202 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACY1 (3p21.2) / MC1R (16q24.3)SERINC2 (1p35.2) / ACY1 (3p21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACY1   177
Cards
Entrez_Gene (NCBI)ACY1  95  aminoacylase 1
AliasesACY-1; ACY1D; HEL-S-5
GeneCards (Weizmann)ACY1
Ensembl hg19 (Hinxton)ENSG00000114786 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114786 [Gene_View]  chr3:51983284-51989202 [Contig_View]  ACY1 [Vega]
ICGC DataPortalENSG00000114786
TCGA cBioPortalACY1
AceView (NCBI)ACY1
Genatlas (Paris)ACY1
WikiGenes95
SOURCE (Princeton)ACY1
Genetics Home Reference (NIH)ACY1
Genomic and cartography
GoldenPath hg38 (UCSC)ACY1  -     chr3:51983284-51989202 +  3p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACY1  -     3p21.2   [Description]    (hg19-Feb_2009)
EnsemblACY1 - 3p21.2 [CytoView hg19]  ACY1 - 3p21.2 [CytoView hg38]
Mapping of homologs : NCBIACY1 [Mapview hg19]  ACY1 [Mapview hg38]
OMIM104620   609924   
Gene and transcription
Genbank (Entrez)AK298274 BC000545 BC003023 BC014112 BE269642
RefSeq transcript (Entrez)NM_000666 NM_001198895 NM_001198896 NM_001198897 NM_001198898
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ACY1
Cluster EST : UnigeneHs.334707 [ NCBI ]
CGAP (NCI)Hs.334707
Alternative Splicing GalleryENSG00000114786
Gene ExpressionACY1 [ NCBI-GEO ]   ACY1 [ EBI - ARRAY_EXPRESS ]   ACY1 [ SEEK ]   ACY1 [ MEM ]
Gene Expression Viewer (FireBrowse)ACY1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)95
GTEX Portal (Tissue expression)ACY1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ03154   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ03154  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ03154
Splice isoforms : SwissVarQ03154
Catalytic activity : Enzyme3.5.1.14 [ Enzyme-Expasy ]   3.5.1.143.5.1.14 [ IntEnz-EBI ]   3.5.1.14 [ BRENDA ]   3.5.1.14 [ KEGG ]   
PhosPhoSitePlusQ03154
Domaine pattern : Prosite (Expaxy)ARGE_DAPE_CPG2_1 (PS00758)    ARGE_DAPE_CPG2_2 (PS00759)   
Domains : Interpro (EBI)ArgE/DapE_CS    N-acyl_aa_amidohydrolase    Peptidase_M20    Peptidase_M20_dimer   
Domain families : Pfam (Sanger)M20_dimer (PF07687)    Peptidase_M20 (PF01546)   
Domain families : Pfam (NCBI)pfam07687    pfam01546   
Conserved Domain (NCBI)ACY1
DMDM Disease mutations95
Blocks (Seattle)ACY1
PDB (SRS)1Q7L   
PDB (PDBSum)1Q7L   
PDB (IMB)1Q7L   
PDB (RSDB)1Q7L   
Structural Biology KnowledgeBase1Q7L   
SCOP (Structural Classification of Proteins)1Q7L   
CATH (Classification of proteins structures)1Q7L   
SuperfamilyQ03154
Human Protein AtlasENSG00000114786
Peptide AtlasQ03154
HPRD00092
IPIIPI00940464   IPI00946958   IPI00947447   IPI00788719   IPI00791053   IPI00792542   IPI00947555   IPI00945211   
Protein Interaction databases
DIP (DOE-UCLA)Q03154
IntAct (EBI)Q03154
FunCoupENSG00000114786
BioGRIDACY1
STRING (EMBL)ACY1
ZODIACACY1
Ontologies - Pathways
QuickGOQ03154
Ontology : AmiGOaminoacylase activity  protein binding  cytosol  proteolysis  cellular amino acid metabolic process  xenobiotic metabolic process  metallopeptidase activity  identical protein binding  metal ion binding  extracellular exosome  
Ontology : EGO-EBIaminoacylase activity  protein binding  cytosol  proteolysis  cellular amino acid metabolic process  xenobiotic metabolic process  metallopeptidase activity  identical protein binding  metal ion binding  extracellular exosome  
Pathways : KEGGArginine and proline metabolism   
NDEx NetworkACY1
Atlas of Cancer Signalling NetworkACY1
Wikipedia pathwaysACY1
Orthology - Evolution
OrthoDB95
GeneTree (enSembl)ENSG00000114786
Phylogenetic Trees/Animal Genes : TreeFamACY1
HOVERGENQ03154
HOGENOMQ03154
Homologs : HomoloGeneACY1
Homology/Alignments : Family Browser (UCSC)ACY1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACY1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACY1
dbVarACY1
ClinVarACY1
1000_GenomesACY1 
Exome Variant ServerACY1
ExAC (Exome Aggregation Consortium)ACY1 (select the gene name)
Genetic variants : HAPMAP95
Genomic Variants (DGV)ACY1 [DGVbeta]
DECIPHERACY1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACY1 
Mutations
ICGC Data PortalACY1 
TCGA Data PortalACY1 
Broad Tumor PortalACY1
OASIS PortalACY1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACY1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDACY1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ACY1
DgiDB (Drug Gene Interaction Database)ACY1
DoCM (Curated mutations)ACY1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACY1 (select a term)
intoGenACY1
Cancer3DACY1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104620    609924   
Orphanet16711   
MedgenACY1
Genetic Testing Registry ACY1
NextProtQ03154 [Medical]
TSGene95
GENETestsACY1
Huge Navigator ACY1 [HugePedia]
snp3D : Map Gene to Disease95
BioCentury BCIQACY1
ClinGenACY1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD95
Chemical/Pharm GKB GenePA24497
Clinical trialACY1
Miscellaneous
canSAR (ICR)ACY1 (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACY1
EVEXACY1
GoPubMedACY1
iHOPACY1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:04:55 CEST 2017

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