Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADA (adenosine deaminase)

Identity

Other alias-
HGNC (Hugo) ADA
LocusID (NCBI) 100
Atlas_Id 43101
Location 20q13.12  [Link to chromosome band 20q13]
Location_base_pair Starts at 44619519 and ends at 44651758 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KIAA0430 (16p13.11) / ADA (20q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  dic(17;20)(p11.2;q11.2)
ider(20q) in Myeloid Malignancies


External links

Nomenclature
HGNC (Hugo)ADA   186
LRG (Locus Reference Genomic)LRG_16
Cards
Entrez_Gene (NCBI)ADA  100  adenosine deaminase
Aliases
GeneCards (Weizmann)ADA
Ensembl hg19 (Hinxton)ENSG00000196839 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196839 [Gene_View]  chr20:44619519-44651758 [Contig_View]  ADA [Vega]
ICGC DataPortalENSG00000196839
TCGA cBioPortalADA
AceView (NCBI)ADA
Genatlas (Paris)ADA
WikiGenes100
SOURCE (Princeton)ADA
Genetics Home Reference (NIH)ADA
Genomic and cartography
GoldenPath hg38 (UCSC)ADA  -     chr20:44619519-44651758 -  20q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADA  -     20q13.12   [Description]    (hg19-Feb_2009)
EnsemblADA - 20q13.12 [CytoView hg19]  ADA - 20q13.12 [CytoView hg38]
Mapping of homologs : NCBIADA [Mapview hg19]  ADA [Mapview hg38]
OMIM102700   608958   
Gene and transcription
Genbank (Entrez)AK123988 AK223397 AL832305 AW450871 BC007678
RefSeq transcript (Entrez)NM_000022 NM_001322050 NM_001322051
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADA
Cluster EST : UnigeneHs.654536 [ NCBI ]
CGAP (NCI)Hs.654536
Alternative Splicing GalleryENSG00000196839
Gene ExpressionADA [ NCBI-GEO ]   ADA [ EBI - ARRAY_EXPRESS ]   ADA [ SEEK ]   ADA [ MEM ]
Gene Expression Viewer (FireBrowse)ADA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)100
GTEX Portal (Tissue expression)ADA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00813   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00813  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00813
Splice isoforms : SwissVarP00813
PhosPhoSitePlusP00813
Domaine pattern : Prosite (Expaxy)A_DEAMINASE (PS00485)   
Domains : Interpro (EBI)A/AMP_deam_AS    A/AMP_deaminase_dom    A_deaminase    Ado/ade_deaminase    Metal_Hydrolase   
Domain families : Pfam (Sanger)A_deaminase (PF00962)   
Domain families : Pfam (NCBI)pfam00962   
Conserved Domain (NCBI)ADA
DMDM Disease mutations100
Blocks (Seattle)ADA
PDB (SRS)1M7M    3IAR   
PDB (PDBSum)1M7M    3IAR   
PDB (IMB)1M7M    3IAR   
PDB (RSDB)1M7M    3IAR   
Structural Biology KnowledgeBase1M7M    3IAR   
SCOP (Structural Classification of Proteins)1M7M    3IAR   
CATH (Classification of proteins structures)1M7M    3IAR   
SuperfamilyP00813
Human Protein AtlasENSG00000196839
Peptide AtlasP00813
HPRD00038
IPIIPI00296441   IPI01009970   IPI01009555   IPI01012449   
Protein Interaction databases
DIP (DOE-UCLA)P00813
IntAct (EBI)P00813
FunCoupENSG00000196839
BioGRIDADA
STRING (EMBL)ADA
ZODIACADA
Ontologies - Pathways
QuickGOP00813
Ontology : AmiGOresponse to hypoxia  histamine secretion  trophectodermal cell differentiation  purine nucleoside binding  liver development  placenta development  germinal center B cell differentiation  positive regulation of germinal center formation  negative regulation of leukocyte migration  negative regulation of mature B cell apoptotic process  adenosine deaminase activity  adenosine deaminase activity  adenosine deaminase activity  protein binding  extracellular space  lysosome  cytosol  adenosine catabolic process  adenosine catabolic process  deoxyadenosine catabolic process  cell adhesion  aging  zinc ion binding  zinc ion binding  purine ribonucleoside monophosphate biosynthetic process  external side of plasma membrane  cell surface  positive regulation of heart rate  membrane  cell junction  positive regulation of B cell proliferation  purine nucleotide salvage  dendrite cytoplasm  positive regulation of T cell differentiation in thymus  response to vitamin E  regulation of cell-cell adhesion mediated by integrin  T cell activation  negative regulation of circadian sleep/wake cycle, non-REM sleep  response to drug  response to hydrogen peroxide  neuronal cell body  purine-containing compound salvage  response to morphine  positive regulation of smooth muscle contraction  dATP catabolic process  hypoxanthine biosynthetic process  inosine biosynthetic process  inosine biosynthetic process  xanthine biosynthetic process  positive regulation of alpha-beta T cell differentiation  lung alveolus development  Peyer's patch development  embryonic digestive tract development  negative regulation of inflammatory response  positive regulation of calcium-mediated signaling  positive regulation of T cell receptor signaling pathway  negative regulation of adenosine receptor signaling pathway  cytoplasmic vesicle lumen  negative regulation of penile erection  negative regulation of thymocyte apoptotic process  negative regulation of mucus secretion  
Ontology : EGO-EBIresponse to hypoxia  histamine secretion  trophectodermal cell differentiation  purine nucleoside binding  liver development  placenta development  germinal center B cell differentiation  positive regulation of germinal center formation  negative regulation of leukocyte migration  negative regulation of mature B cell apoptotic process  adenosine deaminase activity  adenosine deaminase activity  adenosine deaminase activity  protein binding  extracellular space  lysosome  cytosol  adenosine catabolic process  adenosine catabolic process  deoxyadenosine catabolic process  cell adhesion  aging  zinc ion binding  zinc ion binding  purine ribonucleoside monophosphate biosynthetic process  external side of plasma membrane  cell surface  positive regulation of heart rate  membrane  cell junction  positive regulation of B cell proliferation  purine nucleotide salvage  dendrite cytoplasm  positive regulation of T cell differentiation in thymus  response to vitamin E  regulation of cell-cell adhesion mediated by integrin  T cell activation  negative regulation of circadian sleep/wake cycle, non-REM sleep  response to drug  response to hydrogen peroxide  neuronal cell body  purine-containing compound salvage  response to morphine  positive regulation of smooth muscle contraction  dATP catabolic process  hypoxanthine biosynthetic process  inosine biosynthetic process  inosine biosynthetic process  xanthine biosynthetic process  positive regulation of alpha-beta T cell differentiation  lung alveolus development  Peyer's patch development  embryonic digestive tract development  negative regulation of inflammatory response  positive regulation of calcium-mediated signaling  positive regulation of T cell receptor signaling pathway  negative regulation of adenosine receptor signaling pathway  cytoplasmic vesicle lumen  negative regulation of penile erection  negative regulation of thymocyte apoptotic process  negative regulation of mucus secretion  
Pathways : KEGGPurine metabolism    Primary immunodeficiency   
NDEx NetworkADA
Atlas of Cancer Signalling NetworkADA
Wikipedia pathwaysADA
Orthology - Evolution
OrthoDB100
GeneTree (enSembl)ENSG00000196839
Phylogenetic Trees/Animal Genes : TreeFamADA
HOVERGENP00813
HOGENOMP00813
Homologs : HomoloGeneADA
Homology/Alignments : Family Browser (UCSC)ADA
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADA
dbVarADA
ClinVarADA
1000_GenomesADA 
Exome Variant ServerADA
ExAC (Exome Aggregation Consortium)ADA (select the gene name)
Genetic variants : HAPMAP100
Genomic Variants (DGV)ADA [DGVbeta]
DECIPHERADA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADA 
Mutations
ICGC Data PortalADA 
TCGA Data PortalADA 
Broad Tumor PortalADA
OASIS PortalADA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch ADA
DgiDB (Drug Gene Interaction Database)ADA
DoCM (Curated mutations)ADA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADA (select a term)
intoGenADA
Cancer3DADA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM102700    608958   
Orphanet8023    10452   
MedgenADA
Genetic Testing Registry ADA
NextProtP00813 [Medical]
TSGene100
GENETestsADA
Huge Navigator ADA [HugePedia]
snp3D : Map Gene to Disease100
BioCentury BCIQADA
ClinGenADA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD100
Chemical/Pharm GKB GenePA24503
Clinical trialADA
Miscellaneous
canSAR (ICR)ADA (select the gene name)
Probes
Litterature
PubMed218 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADA
EVEXADA
GoPubMedADA
iHOPADA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:04:56 CEST 2017

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