ADAM10 (ADAM metallopeptidase domain 10)

Identity

Other names	CD156c
	HsT18717
	MADM
	kuz
Hugo	ADAM10
Location	15q2|15q22
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
Hugo	ADAM10
GDB	ADAM10
Entrez_Gene	ADAM10  102  ADAM metallopeptidase domain 10
	Cards
GeneCards	ADAM10
Ensembl	ADAM10 [Search_View]   ENSG00000137845 [Gene_View]
Genatlas	ADAM10
GeneLynx	ADAM10
eGenome	ADAM10
euGene	102
	Genomic and cartography
GoldenPath	ADAM10  -  15q2|15q22   chr15:56675802-56829469 -  15q22.1   [Description]    (hg18-March_2006)
Ensembl	ADAM10 - 15q22.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ADAM10
	Gene and transcription
Genbank	AF009615 [ ENTREZ ]
Genbank	AK023460 [ ENTREZ ]
Genbank	BC055087 [ ENTREZ ]
Genbank	BC104659 [ ENTREZ ]
Genbank	BC126253 [ ENTREZ ]
RefSeq	NM_001110 [ SRS ]    NM_001110 [ ENTREZ ]
RefSeq	AC_000058 [ SRS ]    AC_000058 [ ENTREZ ]
RefSeq	NC_000015 [ SRS ]    NC_000015 [ ENTREZ ]
RefSeq	NT_010194 [ SRS ]    NT_010194 [ ENTREZ ]
RefSeq	NW_925884 [ SRS ]    NW_925884 [ ENTREZ ]
AceView	ADAM10 AceView - NCBI
Unigene	Hs.578508 [ SRS ]    Hs.578508 [ NCBI ]     HS578508 [ spliceNest ]
Fast-db	5950 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O14672 [ SRS]    O14672 [ EXPASY ]     O14672 [ INTERPRO ]
Prosite	PS50215 ADAM_MEPRO [ SRS ]    PS50215 ADAM_MEPRO [ Expasy ]
Prosite	PS00546 CYSTEINE_SWITCH [ SRS ]    PS00546 CYSTEINE_SWITCH [ Expasy ]
Prosite	PS00427 DISINTEGRIN_1 [ SRS ]    PS00427 DISINTEGRIN_1 [ Expasy ]
Prosite	PS50214 DISINTEGRIN_2 [ SRS ]    PS50214 DISINTEGRIN_2 [ Expasy ]
Prosite	PS00142 ZINC_PROTEASE [ SRS ]    PS00142 ZINC_PROTEASE [ Expasy ]
Interpro	IPR001762 Blood-coag_inhib_Disintegrin [ SRS ]    IPR001762 Blood-coag_inhib_Disintegrin [ EBI ]
Interpro	IPR001818 Pept_M10A_M12B [ SRS ]    IPR001818 Pept_M10A_M12B [ EBI ]
Interpro	IPR006025 Pept_M_Zn_BS [ SRS ]    IPR006025 Pept_M_Zn_BS [ EBI ]
Interpro	IPR001590 Peptidase_M12B [ SRS ]    IPR001590 Peptidase_M12B [ EBI ]
Interpro	IPR002870 Peptidase_M12B_N [ SRS ]    IPR002870 Peptidase_M12B_N [ EBI ]
CluSTr	O14672
Pfam	PF00200 Disintegrin [ SRS ]    PF00200 Disintegrin [ Sanger ]    pfam00200 [ NCBI-CDD ]
Pfam	PF01562 Pep_M12B_propep [ SRS ]    PF01562 Pep_M12B_propep [ Sanger ]    pfam01562 [ NCBI-CDD ]
Pfam	PF01421 Reprolysin [ SRS ]    PF01421 Reprolysin [ Sanger ]    pfam01421 [ NCBI-CDD ]
Smart	SM00050 DISIN [EMBL]
Prodom	PD000664 Disintegrin[INRA-Toulouse]
Prodom	O14672 ADA10_HUMAN [ Domain structure ]   O14672 ADA10_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	O14672
PDB	1M1I [ SRS ]    1M1I [ PdbSum ],   1M1I [ IMB ]   1M1I [ RSDB ]
HPRD	03723
	Protein Interaction databases
DIP	O14672
IntAct	O14672
	Polymorphism : SNP, mutations, diseases
OMIM	602192    [ map ]
GENECLINICS	602192
SNP	ADAM10 [dbSNP-NCBI]
SNP	NM_001110 [SNP-NCI]
SNP	ADAM10 [GeneSNPs - Utah]  ADAM10] [HGBASE - SRS]
HAPMAP	ADAM10 [HAPMAP]
COSMIC	ADAM10 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ADAM10
	General knowledge
Family Browser	ADAM10 [UCSC Family Browser]
SOURCE	NM_001110
SMD	Hs.578508
SAGE	Hs.578508
Enzyme	3.4.24.81 [ Enzyme-SRS ]   3.4.24.81 [ Brenda-SRS ]   3.4.24.81 [ KEGG ]   3.4.24.81 [ WIT ]
GO	in utero embryonic development [Amigo]  in utero embryonic development
GO	metalloendopeptidase activity [Amigo]  metalloendopeptidase activity
GO	integrin binding [Amigo]  integrin binding
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	Golgi apparatus [Amigo]  Golgi apparatus
GO	Golgi-associated vesicle [Amigo]  Golgi-associated vesicle
GO	plasma membrane [Amigo]  plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	proteolysis [Amigo]  proteolysis
GO	negative regulation of cell adhesion [Amigo]  negative regulation of cell adhesion
GO	negative regulation of cell adhesion [Amigo]  negative regulation of cell adhesion
GO	Notch signaling pathway [Amigo]  Notch signaling pathway
GO	integrin-mediated signaling pathway [Amigo]  integrin-mediated signaling pathway
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	zinc ion binding [Amigo]  zinc ion binding
GO	cell surface [Amigo]  cell surface
GO	integral to membrane [Amigo]  integral to membrane
GO	protein kinase binding [Amigo]  protein kinase binding
GO	protein homodimerization activity [Amigo]  protein homodimerization activity
GO	metal ion binding [Amigo]  metal ion binding
GO	constitutive protein ectodomain proteolysis [Amigo]  constitutive protein ectodomain proteolysis
BIOCARTA	Generation of amyloid b-peptide by PS1    [Genes]
KEGG	Epithelial cell signaling in Helicobacter pylori infection
PubGene	ADAM10
TreeFam	ADAM10
CTD	102 [Comparative Genomics Database]
	Other databases
	Probes
Probe	ADAM10 Related clones (RZPD - Berlin)
	PubMed
PubMed	60 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu May 22 19:54:30 2008