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ADAM11 (ADAM metallopeptidase domain 11)

Identity

Alias_namesdisintegrin-like
cysteine-rich protein
Other aliasMDC
HGNC (Hugo) ADAM11
LocusID (NCBI) 4185
Atlas_Id 571
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 42836547 and ends at 42859214 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAM11   189
Cards
Entrez_Gene (NCBI)ADAM11  4185  ADAM metallopeptidase domain 11
AliasesMDC
GeneCards (Weizmann)ADAM11
Ensembl hg19 (Hinxton)ENSG00000073670 [Gene_View]  chr17:42836547-42859214 [Contig_View]  ADAM11 [Vega]
Ensembl hg38 (Hinxton)ENSG00000073670 [Gene_View]  chr17:42836547-42859214 [Contig_View]  ADAM11 [Vega]
ICGC DataPortalENSG00000073670
TCGA cBioPortalADAM11
AceView (NCBI)ADAM11
Genatlas (Paris)ADAM11
WikiGenes4185
SOURCE (Princeton)ADAM11
Genetics Home Reference (NIH)ADAM11
Genomic and cartography
GoldenPath hg19 (UCSC)ADAM11  -     chr17:42836547-42859214 +  17q21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADAM11  -     17q21.31   [Description]    (hg38-Dec_2013)
EnsemblADAM11 - 17q21.31 [CytoView hg19]  ADAM11 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIADAM11 [Mapview hg19]  ADAM11 [Mapview hg38]
OMIM155120   
Gene and transcription
Genbank (Entrez)AB009675 AK296512 BC111916 BC144550 BM557705
RefSeq transcript (Entrez)NM_001318933 NM_002390
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)ADAM11
Cluster EST : UnigeneHs.6088 [ NCBI ]
CGAP (NCI)Hs.6088
Alternative Splicing GalleryENSG00000073670
Gene ExpressionADAM11 [ NCBI-GEO ]   ADAM11 [ EBI - ARRAY_EXPRESS ]   ADAM11 [ SEEK ]   ADAM11 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAM11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4185
GTEX Portal (Tissue expression)ADAM11
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75078   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75078  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75078
Splice isoforms : SwissVarO75078
PhosPhoSitePlusO75078
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)    EGF_1 (PS00022)    EGF_3 (PS50026)   
Domains : Interpro (EBI)ADAM_Cys-rich    Disintegrin_CS    Disintegrin_dom    EGF-like_CS    EGF-like_dom    EGF_extracell    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_N   
Domain families : Pfam (Sanger)ADAM_CR (PF08516)    Disintegrin (PF00200)    EGF_2 (PF07974)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)   
Domain families : Pfam (NCBI)pfam08516    pfam00200    pfam07974    pfam01562    pfam01421   
Domain families : Smart (EMBL)ACR (SM00608)  DISIN (SM00050)  EGF (SM00181)  
Conserved Domain (NCBI)ADAM11
DMDM Disease mutations4185
Blocks (Seattle)ADAM11
SuperfamilyO75078
Human Protein AtlasENSG00000073670
Peptide AtlasO75078
HPRD01114
IPIIPI00299652   IPI00299653   IPI01013388   
Protein Interaction databases
DIP (DOE-UCLA)O75078
IntAct (EBI)O75078
FunCoupENSG00000073670
BioGRIDADAM11
STRING (EMBL)ADAM11
ZODIACADAM11
Ontologies - Pathways
QuickGOO75078
Ontology : AmiGOmetalloendopeptidase activity  integrin binding  plasma membrane  proteolysis  integrin-mediated signaling pathway  metallopeptidase activity  zinc ion binding  integral component of membrane  extracellular matrix  
Ontology : EGO-EBImetalloendopeptidase activity  integrin binding  plasma membrane  proteolysis  integrin-mediated signaling pathway  metallopeptidase activity  zinc ion binding  integral component of membrane  extracellular matrix  
NDEx NetworkADAM11
Atlas of Cancer Signalling NetworkADAM11
Wikipedia pathwaysADAM11
Orthology - Evolution
OrthoDB4185
GeneTree (enSembl)ENSG00000073670
Phylogenetic Trees/Animal Genes : TreeFamADAM11
HOVERGENO75078
HOGENOMO75078
Homologs : HomoloGeneADAM11
Homology/Alignments : Family Browser (UCSC)ADAM11
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAM11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAM11
dbVarADAM11
ClinVarADAM11
1000_GenomesADAM11 
Exome Variant ServerADAM11
ExAC (Exome Aggregation Consortium)ADAM11 (select the gene name)
Genetic variants : HAPMAP4185
Genomic Variants (DGV)ADAM11 [DGVbeta]
DECIPHER (Syndromes)17:42836547-42859214  ENSG00000073670
CONAN: Copy Number AnalysisADAM11 
Mutations
ICGC Data PortalADAM11 
TCGA Data PortalADAM11 
Broad Tumor PortalADAM11
OASIS PortalADAM11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAM11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAM11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAM11
DgiDB (Drug Gene Interaction Database)ADAM11
DoCM (Curated mutations)ADAM11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAM11 (select a term)
intoGenADAM11
Cancer3DADAM11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM155120   
Orphanet
MedgenADAM11
Genetic Testing Registry ADAM11
NextProtO75078 [Medical]
TSGene4185
GENETestsADAM11
Huge Navigator ADAM11 [HugePedia]
snp3D : Map Gene to Disease4185
BioCentury BCIQADAM11
ClinGenADAM11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4185
Chemical/Pharm GKB GenePA24506
Clinical trialADAM11
Miscellaneous
canSAR (ICR)ADAM11 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAM11
EVEXADAM11
GoPubMedADAM11
iHOPADAM11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:54:48 CET 2017

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