ADAM15 (ADAM metallopeptidase domain 15)

2007-02-01  

Identity

HGNC
ADAM15
LOCATION
1q21.3
LOCUSID
8751
ALIAS
MDC15
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8751
MIM: 605548
HGNC: 193
Ensembl: ENSG00000143537

Variants:

dbSNP: 8751
ClinVar: 8751
TCGA: ENSG00000143537
COSMIC: ADAM15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143537ENST00000271836Q13444
ENSG00000143537ENST00000355956Q13444
ENSG00000143537ENST00000356955Q13444
ENSG00000143537ENST00000359280Q13444
ENSG00000143537ENST00000360674Q13444
ENSG00000143537ENST00000368412Q13444
ENSG00000143537ENST00000368413Q13444
ENSG00000143537ENST00000447332Q13444
ENSG00000143537ENST00000449910Q13444
ENSG00000143537ENST00000526491Q13444
ENSG00000143537ENST00000529473Q13444
ENSG00000143537ENST00000531455Q13444

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
184343112008The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation.77
118826572002Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.50
128971352003Potential role for ADAM15 in pathological neovascularization in mice.47
127773992003Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23.43
167567242006ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease.33
120913802002The role of ADAM 15 in glomerular mesangial cell migration.30
182814842008ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction.30
117419292002Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.28
201899532010ADAM15 regulates endothelial permeability and neutrophil migration via Src/ERK1/2 signalling.28
182966482008Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.20

Citation

Dessen P

ADAM15 (ADAM metallopeptidase domain 15)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46345/adam15