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ADAM15 (ADAM metallopeptidase domain 15)

Identity

Alias_namesa disintegrin and metalloproteinase domain 15 (metargidin)
Alias_symbol (synonym)MDC15
Other alias
HGNC (Hugo) ADAM15
LocusID (NCBI) 8751
Atlas_Id 46345
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 155051272 and ends at 155062776 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAM15 (1q22) / DCST1 (1q22)ADAM15 1q22 / DCST1 1q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ADAM15   193
Cards
Entrez_Gene (NCBI)ADAM15  8751  ADAM metallopeptidase domain 15
AliasesMDC15
GeneCards (Weizmann)ADAM15
Ensembl hg19 (Hinxton)ENSG00000143537 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143537 [Gene_View]  ENSG00000143537 [Sequence]  chr1:155051272-155062776 [Contig_View]  ADAM15 [Vega]
ICGC DataPortalENSG00000143537
TCGA cBioPortalADAM15
AceView (NCBI)ADAM15
Genatlas (Paris)ADAM15
WikiGenes8751
SOURCE (Princeton)ADAM15
Genetics Home Reference (NIH)ADAM15
Genomic and cartography
GoldenPath hg38 (UCSC)ADAM15  -     chr1:155051272-155062776 +  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAM15  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblADAM15 - 1q21.3 [CytoView hg19]  ADAM15 - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBIADAM15 [Mapview hg19]  ADAM15 [Mapview hg38]
OMIM605548   
Gene and transcription
Genbank (Entrez)AB209157 AK000667 AK075498 AK295614 AK296925
RefSeq transcript (Entrez)NM_001261464 NM_001261465 NM_001261466 NM_003815 NM_207191 NM_207194 NM_207195 NM_207196 NM_207197
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAM15
Cluster EST : UnigeneHs.312098 [ NCBI ]
CGAP (NCI)Hs.312098
Alternative Splicing GalleryENSG00000143537
Gene ExpressionADAM15 [ NCBI-GEO ]   ADAM15 [ EBI - ARRAY_EXPRESS ]   ADAM15 [ SEEK ]   ADAM15 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAM15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8751
GTEX Portal (Tissue expression)ADAM15
Human Protein AtlasENSG00000143537-ADAM15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13444   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13444  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13444
Splice isoforms : SwissVarQ13444
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ13444
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    DISINTEGRIN_2 (PS50214)    EGF_2 (PS01186)    EGF_3 (PS50026)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM15    ADAM_Cys-rich    Disintegrin_dom    EGF-like_CS    EGF-like_dom    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_N    Reprolysin_adamalysin   
Domain families : Pfam (Sanger)ADAM_CR (PF08516)    Disintegrin (PF00200)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)   
Domain families : Pfam (NCBI)pfam08516    pfam00200    pfam01562    pfam01421   
Domain families : Smart (EMBL)ACR (SM00608)  DISIN (SM00050)  
Conserved Domain (NCBI)ADAM15
DMDM Disease mutations8751
Blocks (Seattle)ADAM15
SuperfamilyQ13444
Human Protein Atlas [tissue]ENSG00000143537-ADAM15 [tissue]
Peptide AtlasQ13444
HPRD05674
IPIIPI00420070   IPI00742904   IPI00513871   IPI00013302   IPI00420068   IPI00420069   IPI00420067   IPI00969145   IPI00969092   IPI00969132   IPI00843806   IPI00909666   IPI00981280   
Protein Interaction databases
DIP (DOE-UCLA)Q13444
IntAct (EBI)Q13444
FunCoupENSG00000143537
BioGRIDADAM15
STRING (EMBL)ADAM15
ZODIACADAM15
Ontologies - Pathways
QuickGOQ13444
Ontology : AmiGOangiogenesis  acrosomal vesicle  negative regulation of cell-matrix adhesion  immune response to tumor cell  metalloendopeptidase activity  integrin binding  protein binding  plasma membrane  adherens junction  proteolysis  apoptotic process  cell-matrix adhesion  integrin-mediated signaling pathway  metallopeptidase activity  male gonad development  cell surface  integral component of membrane  SH3 domain binding  extracellular matrix disassembly  extracellular matrix organization  negative regulation of cell growth  negative regulation of cell migration  collagen catabolic process  tissue regeneration  cell projection  innate immune response  metal ion binding  cardiac epithelial to mesenchymal transition  extracellular exosome  protein kinase C signaling  negative regulation of receptor binding  
Ontology : EGO-EBIangiogenesis  acrosomal vesicle  negative regulation of cell-matrix adhesion  immune response to tumor cell  metalloendopeptidase activity  integrin binding  protein binding  plasma membrane  adherens junction  proteolysis  apoptotic process  cell-matrix adhesion  integrin-mediated signaling pathway  metallopeptidase activity  male gonad development  cell surface  integral component of membrane  SH3 domain binding  extracellular matrix disassembly  extracellular matrix organization  negative regulation of cell growth  negative regulation of cell migration  collagen catabolic process  tissue regeneration  cell projection  innate immune response  metal ion binding  cardiac epithelial to mesenchymal transition  extracellular exosome  protein kinase C signaling  negative regulation of receptor binding  
NDEx NetworkADAM15
Atlas of Cancer Signalling NetworkADAM15
Wikipedia pathwaysADAM15
Orthology - Evolution
OrthoDB8751
GeneTree (enSembl)ENSG00000143537
Phylogenetic Trees/Animal Genes : TreeFamADAM15
HOVERGENQ13444
HOGENOMQ13444
Homologs : HomoloGeneADAM15
Homology/Alignments : Family Browser (UCSC)ADAM15
Gene fusions - Rearrangements
Fusion PortalADAM15 1q22 DCST1 1q22 KIRC
Fusion : QuiverADAM15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAM15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAM15
dbVarADAM15
ClinVarADAM15
1000_GenomesADAM15 
Exome Variant ServerADAM15
ExAC (Exome Aggregation Consortium)ENSG00000143537
GNOMAD BrowserENSG00000143537
Genetic variants : HAPMAP8751
Genomic Variants (DGV)ADAM15 [DGVbeta]
DECIPHERADAM15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAM15 
Mutations
ICGC Data PortalADAM15 
TCGA Data PortalADAM15 
Broad Tumor PortalADAM15
OASIS PortalADAM15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAM15  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAM15
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAM15
DgiDB (Drug Gene Interaction Database)ADAM15
DoCM (Curated mutations)ADAM15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAM15 (select a term)
intoGenADAM15
Cancer3DADAM15(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605548   
Orphanet
DisGeNETADAM15
MedgenADAM15
Genetic Testing Registry ADAM15
NextProtQ13444 [Medical]
TSGene8751
GENETestsADAM15
Target ValidationADAM15
Huge Navigator ADAM15 [HugePedia]
snp3D : Map Gene to Disease8751
BioCentury BCIQADAM15
ClinGenADAM15
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8751
Chemical/Pharm GKB GenePA24510
Clinical trialADAM15
Miscellaneous
canSAR (ICR)ADAM15 (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAM15
EVEXADAM15
GoPubMedADAM15
iHOPADAM15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:12:57 CEST 2018
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