ADAM17 (ADAM metallopeptidase domain 17)

Identity

Other names	CD156b
	MGC71942
	TACE
	cSVP
HGNC	ADAM17
Location	2p25
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ADAM17   195
Entrez_Gene	ADAM17  6868  ADAM metallopeptidase domain 17
	Cards
GeneCards	ADAM17
Ensembl	ADAM17 [Search_View]   ENSG00000151694 [Gene_View]
Genatlas	ADAM17
GeneLynx	ADAM17
eGenome	ADAM17
euGene	6868
	Genomic and cartography
GoldenPath	ADAM17  -  2p25   chr2:9546862-9613368 -  2p25.1   [Description]    (hg18-March_2006)
Ensembl	ADAM17 - 2p25.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ADAM17
	Gene and transcription
Genbank	AK289829 [ ENTREZ ]
Genbank	AY422721 [ ENTREZ ]
Genbank	BC062687 [ ENTREZ ]
Genbank	BC136783 [ ENTREZ ]
Genbank	BC146658 [ ENTREZ ]
RefSeq	NM_003183 [ SRS ]    NM_003183 [ ENTREZ ]
RefSeq	AC_000045 [ SRS ]    AC_000045 [ ENTREZ ]
RefSeq	AC_000134 [ SRS ]    AC_000134 [ ENTREZ ]
RefSeq	NC_000002 [ SRS ]    NC_000002 [ ENTREZ ]
RefSeq	NT_005334 [ SRS ]    NT_005334 [ ENTREZ ]
RefSeq	NW_001838766 [ SRS ]    NW_001838766 [ ENTREZ ]
RefSeq	NW_927719 [ SRS ]    NW_927719 [ ENTREZ ]
AceView	ADAM17 AceView - NCBI
Unigene	Hs.404914 [ SRS ]    Hs.404914 [ NCBI ]     HS404914 [ spliceNest ]
Fast-db	1176 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P78536 [ SRS]    P78536 [ EXPASY ]     P78536 [ INTERPRO ]     P78536 [ UNIPROT ]
Prosite	PS50215 ADAM_MEPRO [ SRS ]    PS50215 ADAM_MEPRO [ Expasy ]
Prosite	PS00546 CYSTEINE_SWITCH [ SRS ]    PS00546 CYSTEINE_SWITCH [ Expasy ]
Prosite	PS00427 DISINTEGRIN_1 [ SRS ]    PS00427 DISINTEGRIN_1 [ Expasy ]
Prosite	PS50214 DISINTEGRIN_2 [ SRS ]    PS50214 DISINTEGRIN_2 [ Expasy ]
Prosite	PS00142 ZINC_PROTEASE [ SRS ]    PS00142 ZINC_PROTEASE [ Expasy ]
Interpro	IPR001762 Blood-coag_inhib_Disintegrin [ SRS ]    IPR001762 Blood-coag_inhib_Disintegrin [ EBI ]
Interpro	IPR013032 EGF_like_reg_CS [ SRS ]    IPR013032 EGF_like_reg_CS [ EBI ]
Interpro	IPR001818 Pept_M10A_M12B [ SRS ]    IPR001818 Pept_M10A_M12B [ EBI ]
Interpro	IPR006025 Pept_M_Zn_BS [ SRS ]    IPR006025 Pept_M_Zn_BS [ EBI ]
Interpro	IPR001590 Peptidase_M12B [ SRS ]    IPR001590 Peptidase_M12B [ EBI ]
CluSTr	P78536
Pfam	PF00200 Disintegrin [ SRS ]    PF00200 Disintegrin [ Sanger ]    pfam00200 [ NCBI-CDD ]
Pfam	PF01421 Reprolysin [ SRS ]    PF01421 Reprolysin [ Sanger ]    pfam01421 [ NCBI-CDD ]
Smart	SM00050 DISIN [EMBL]
Prodom	PD000664 Disintegrin[INRA-Toulouse]
Prodom	P78536 ADA17_HUMAN [ Domain structure ]   P78536 ADA17_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P78536
PDB	1BKC [ SRS ]    1BKC [ PdbSum ],   1BKC [ IMB ]   1BKC [ RSDB ]
PDB	1ZXC [ SRS ]    1ZXC [ PdbSum ],   1ZXC [ IMB ]   1ZXC [ RSDB ]
PDB	2A8H [ SRS ]    2A8H [ PdbSum ],   2A8H [ IMB ]   2A8H [ RSDB ]
PDB	2DDF [ SRS ]    2DDF [ PdbSum ],   2DDF [ IMB ]   2DDF [ RSDB ]
PDB	2FV5 [ SRS ]    2FV5 [ PdbSum ],   2FV5 [ IMB ]   2FV5 [ RSDB ]
PDB	2FV9 [ SRS ]    2FV9 [ PdbSum ],   2FV9 [ IMB ]   2FV9 [ RSDB ]
PDB	2I47 [ SRS ]    2I47 [ PdbSum ],   2I47 [ IMB ]   2I47 [ RSDB ]
PDB	2OI0 [ SRS ]    2OI0 [ PdbSum ],   2OI0 [ IMB ]   2OI0 [ RSDB ]
PDB	3B92 [ SRS ]    3B92 [ PdbSum ],   3B92 [ IMB ]   3B92 [ RSDB ]
HPRD	04703
	Protein Interaction databases
DIP	P78536
IntAct	P78536
	Polymorphism : SNP, mutations, diseases
OMIM	603639    [ map ]
GENECLINICS	603639
SNP	ADAM17 [dbSNP-NCBI]
SNP	NM_003183 [SNP-NCI]
SNP	ADAM17 [GeneSNPs - Utah]  ADAM17] [HGBASE - SRS]
HAPMAP	ADAM17 [HAPMAP]
COSMIC	ADAM17 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ADAM17
	General knowledge
Family Browser	ADAM17 [UCSC Family Browser]
SOURCE	NM_003183
SMD	Hs.404914
SAGE	Hs.404914
Enzyme	3.4.24.86 [ Enzyme-Expasy ]   3.4.24.86 [ Enzyme-SRS ]   3.4.24.86 [ IntEnz-EBI ]   3.4.24.86 [ BRENDA ]   3.4.24.86 [ KEGG ]   3.4.24.86 [ WIT ]
GO	metalloendopeptidase activity [Amigo]  metalloendopeptidase activity
GO	protein binding [Amigo]  protein binding
GO	cytoplasm [Amigo]  cytoplasm
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	proteolysis [Amigo]  proteolysis
GO	Notch signaling pathway [Amigo]  Notch signaling pathway
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	zinc ion binding [Amigo]  zinc ion binding
GO	membrane [Amigo]  membrane
GO	metal ion binding [Amigo]  metal ion binding
BIOCARTA	g-Secretase mediated ErbB4 Signaling    [Genes]
BIOCARTA	Proteolysis and Signaling of Notch    [Genes]
BIOCARTA	Presenilin action in Notch and Wnt signaling    [Genes]
KEGG	Notch signaling pathway
KEGG	Epithelial cell signaling in Helicobacter pylori infection
PubGene	ADAM17
TreeFam	ADAM17
CTD	6868 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ADAM17 Related clones (RZPD - Berlin)
	PubMed
PubMed	94 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 19:58:52 2008