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ADAM18 (ADAM metallopeptidase domain 18)

Identity

Alias_namesa disintegrin and metalloproteinase domain 18
Alias_symbol (synonym)tMDCIII
ADAM27
Other alias
HGNC (Hugo) ADAM18
LocusID (NCBI) 8749
Atlas_Id 47524
Location 8p11.22  [Link to chromosome band 8p11]
Location_base_pair Starts at 39584568 and ends at 39611575 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAM18 (8p11.22) / LSM1 (8p11.23)ADAM18 (8p11.22) / PLPP5 (8p11.23)FGFR1 (8p11.23) / ADAM18 (8p11.22)
RAB8A (19p13.12) / ADAM18 (8p11.22)WHSC1L1 (8p11.23) / ADAM18 (8p11.22)ADAM18 8p11.22 / LSM1 8p11.23
FGFR1 8p11.23 / ADAM18 8p11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAM18   196
Cards
Entrez_Gene (NCBI)ADAM18  8749  ADAM metallopeptidase domain 18
AliasesADAM27; tMDCIII
GeneCards (Weizmann)ADAM18
Ensembl hg19 (Hinxton)ENSG00000168619 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168619 [Gene_View]  chr8:39584568-39611575 [Contig_View]  ADAM18 [Vega]
ICGC DataPortalENSG00000168619
TCGA cBioPortalADAM18
AceView (NCBI)ADAM18
Genatlas (Paris)ADAM18
WikiGenes8749
SOURCE (Princeton)ADAM18
Genetics Home Reference (NIH)ADAM18
Genomic and cartography
GoldenPath hg38 (UCSC)ADAM18  -     chr8:39584568-39611575 +  8p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAM18  -     8p11.22   [Description]    (hg19-Feb_2009)
EnsemblADAM18 - 8p11.22 [CytoView hg19]  ADAM18 - 8p11.22 [CytoView hg38]
Mapping of homologs : NCBIADAM18 [Mapview hg19]  ADAM18 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AJ133004 AK225744 AK313961 AY358321 BC034624
RefSeq transcript (Entrez)NM_001190956 NM_001320313 NM_014237
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_187577
Consensus coding sequences : CCDS (NCBI)ADAM18
Cluster EST : UnigeneHs.127930 [ NCBI ]
CGAP (NCI)Hs.127930
Alternative Splicing GalleryENSG00000168619
Gene ExpressionADAM18 [ NCBI-GEO ]   ADAM18 [ EBI - ARRAY_EXPRESS ]   ADAM18 [ SEEK ]   ADAM18 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAM18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8749
GTEX Portal (Tissue expression)ADAM18
Human Protein AtlasENSG00000168619-ADAM18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y3Q7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y3Q7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y3Q7
Splice isoforms : SwissVarQ9Y3Q7
PhosPhoSitePlusQ9Y3Q7
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)   
Domains : Interpro (EBI)ADAM_Cys-rich    Disintegrin_CS    Disintegrin_dom    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_N    Reprolysin_adamalysin   
Domain families : Pfam (Sanger)ADAM_CR (PF08516)    Disintegrin (PF00200)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)   
Domain families : Pfam (NCBI)pfam08516    pfam00200    pfam01562    pfam01421   
Domain families : Smart (EMBL)ACR (SM00608)  DISIN (SM00050)  
Conserved Domain (NCBI)ADAM18
DMDM Disease mutations8749
Blocks (Seattle)ADAM18
SuperfamilyQ9Y3Q7
Human Protein Atlas [tissue]ENSG00000168619-ADAM18 [tissue]
Peptide AtlasQ9Y3Q7
HPRD07469
IPIIPI00003365   IPI00479446   IPI01015444   IPI00974202   IPI01013221   IPI00975987   IPI00980425   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y3Q7
IntAct (EBI)Q9Y3Q7
FunCoupENSG00000168619
BioGRIDADAM18
STRING (EMBL)ADAM18
ZODIACADAM18
Ontologies - Pathways
QuickGOQ9Y3Q7
Ontology : AmiGOmetalloendopeptidase activity  proteolysis  multicellular organism development  spermatogenesis  metallopeptidase activity  membrane  integral component of membrane  cell differentiation  
Ontology : EGO-EBImetalloendopeptidase activity  proteolysis  multicellular organism development  spermatogenesis  metallopeptidase activity  membrane  integral component of membrane  cell differentiation  
NDEx NetworkADAM18
Atlas of Cancer Signalling NetworkADAM18
Wikipedia pathwaysADAM18
Orthology - Evolution
OrthoDB8749
GeneTree (enSembl)ENSG00000168619
Phylogenetic Trees/Animal Genes : TreeFamADAM18
HOVERGENQ9Y3Q7
HOGENOMQ9Y3Q7
Homologs : HomoloGeneADAM18
Homology/Alignments : Family Browser (UCSC)ADAM18
Gene fusions - Rearrangements
Fusion : MitelmanADAM18/LSM1 [8p11.22/8p11.23]  
Fusion : MitelmanFGFR1/ADAM18 [8p11.23/8p11.22]  [t(8;8)(p11;p11)]  
Fusion: TCGA_MDACCADAM18 8p11.22 LSM1 8p11.23 BRCA
Fusion: TCGA_MDACCFGFR1 8p11.23 ADAM18 8p11.22 BRCA
Tumor Fusion PortalADAM18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAM18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAM18
dbVarADAM18
ClinVarADAM18
1000_GenomesADAM18 
Exome Variant ServerADAM18
ExAC (Exome Aggregation Consortium)ENSG00000168619
GNOMAD BrowserENSG00000168619
Genetic variants : HAPMAP8749
Genomic Variants (DGV)ADAM18 [DGVbeta]
DECIPHERADAM18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAM18 
Mutations
ICGC Data PortalADAM18 
TCGA Data PortalADAM18 
Broad Tumor PortalADAM18
OASIS PortalADAM18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAM18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAM18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAM18
DgiDB (Drug Gene Interaction Database)ADAM18
DoCM (Curated mutations)ADAM18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAM18 (select a term)
intoGenADAM18
Cancer3DADAM18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETADAM18
MedgenADAM18
Genetic Testing Registry ADAM18
NextProtQ9Y3Q7 [Medical]
TSGene8749
GENETestsADAM18
Target ValidationADAM18
Huge Navigator ADAM18 [HugePedia]
snp3D : Map Gene to Disease8749
BioCentury BCIQADAM18
ClinGenADAM18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8749
Chemical/Pharm GKB GenePA24513
Clinical trialADAM18
Miscellaneous
canSAR (ICR)ADAM18 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAM18
EVEXADAM18
GoPubMedADAM18
iHOPADAM18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:02:01 CET 2017

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