Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ADAM18 (ADAM metallopeptidase domain 18)

Identity

Alias_namesa disintegrin and metalloproteinase domain 18
Alias_symbol (synonym)tMDCIII
ADAM27
Other alias
HGNC (Hugo) ADAM18
LocusID (NCBI) 8749
Atlas_Id 47524
Location 8p11.22  [Link to chromosome band 8p11]
Location_base_pair Starts at 39442087 and ends at 39469094 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADAM18 (8p11.22) / LSM1 (8p11.23)ADAM18 (8p11.22) / PLPP5 (8p11.23)FGFR1 (8p11.23) / ADAM18 (8p11.22)
RAB8A (19p13.12) / ADAM18 (8p11.22)WHSC1L1 (8p11.23) / ADAM18 (8p11.22)ADAM18 8p11.22 / LSM1 8p11.23
FGFR1 8p11.23 / ADAM18 8p11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAM18   196
Cards
Entrez_Gene (NCBI)ADAM18  8749  ADAM metallopeptidase domain 18
AliasesADAM27; tMDCIII
GeneCards (Weizmann)ADAM18
Ensembl hg19 (Hinxton)ENSG00000168619 [Gene_View]  chr8:39442087-39469094 [Contig_View]  ADAM18 [Vega]
Ensembl hg38 (Hinxton)ENSG00000168619 [Gene_View]  chr8:39442087-39469094 [Contig_View]  ADAM18 [Vega]
ICGC DataPortalENSG00000168619
TCGA cBioPortalADAM18
AceView (NCBI)ADAM18
Genatlas (Paris)ADAM18
WikiGenes8749
SOURCE (Princeton)ADAM18
Genetics Home Reference (NIH)ADAM18
Genomic and cartography
GoldenPath hg19 (UCSC)ADAM18  -     chr8:39442087-39469094 +  8p11.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADAM18  -     8p11.22   [Description]    (hg38-Dec_2013)
EnsemblADAM18 - 8p11.22 [CytoView hg19]  ADAM18 - 8p11.22 [CytoView hg38]
Mapping of homologs : NCBIADAM18 [Mapview hg19]  ADAM18 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AJ133004 AK225744 AK313961 AY358321 BC034624
RefSeq transcript (Entrez)NM_001190956 NM_001320313 NM_014237
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_167187 NT_187577 NW_004929337
Consensus coding sequences : CCDS (NCBI)ADAM18
Cluster EST : UnigeneHs.127930 [ NCBI ]
CGAP (NCI)Hs.127930
Alternative Splicing GalleryENSG00000168619
Gene ExpressionADAM18 [ NCBI-GEO ]   ADAM18 [ EBI - ARRAY_EXPRESS ]   ADAM18 [ SEEK ]   ADAM18 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAM18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8749
GTEX Portal (Tissue expression)ADAM18
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y3Q7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y3Q7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y3Q7
Splice isoforms : SwissVarQ9Y3Q7
PhosPhoSitePlusQ9Y3Q7
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)   
Domains : Interpro (EBI)ADAM_Cys-rich    Disintegrin_CS    Disintegrin_dom    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_N   
Domain families : Pfam (Sanger)ADAM_CR (PF08516)    Disintegrin (PF00200)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)   
Domain families : Pfam (NCBI)pfam08516    pfam00200    pfam01562    pfam01421   
Domain families : Smart (EMBL)ACR (SM00608)  DISIN (SM00050)  
Conserved Domain (NCBI)ADAM18
DMDM Disease mutations8749
Blocks (Seattle)ADAM18
SuperfamilyQ9Y3Q7
Human Protein AtlasENSG00000168619
Peptide AtlasQ9Y3Q7
HPRD07469
IPIIPI00003365   IPI00479446   IPI01015444   IPI00974202   IPI01013221   IPI00975987   IPI00980425   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y3Q7
IntAct (EBI)Q9Y3Q7
FunCoupENSG00000168619
BioGRIDADAM18
STRING (EMBL)ADAM18
ZODIACADAM18
Ontologies - Pathways
QuickGOQ9Y3Q7
Ontology : AmiGOmetalloendopeptidase activity  proteolysis  multicellular organism development  spermatogenesis  metallopeptidase activity  zinc ion binding  membrane  integral component of membrane  cell differentiation  
Ontology : EGO-EBImetalloendopeptidase activity  proteolysis  multicellular organism development  spermatogenesis  metallopeptidase activity  zinc ion binding  membrane  integral component of membrane  cell differentiation  
NDEx NetworkADAM18
Atlas of Cancer Signalling NetworkADAM18
Wikipedia pathwaysADAM18
Orthology - Evolution
OrthoDB8749
GeneTree (enSembl)ENSG00000168619
Phylogenetic Trees/Animal Genes : TreeFamADAM18
HOVERGENQ9Y3Q7
HOGENOMQ9Y3Q7
Homologs : HomoloGeneADAM18
Homology/Alignments : Family Browser (UCSC)ADAM18
Gene fusions - Rearrangements
Fusion : MitelmanADAM18/LSM1 [8p11.22/8p11.23]  
Fusion : MitelmanFGFR1/ADAM18 [8p11.23/8p11.22]  [t(8;8)(p11;p11)]  
Fusion: TCGAADAM18 8p11.22 LSM1 8p11.23 BRCA
Fusion: TCGAFGFR1 8p11.23 ADAM18 8p11.22 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAM18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAM18
dbVarADAM18
ClinVarADAM18
1000_GenomesADAM18 
Exome Variant ServerADAM18
ExAC (Exome Aggregation Consortium)ADAM18 (select the gene name)
Genetic variants : HAPMAP8749
Genomic Variants (DGV)ADAM18 [DGVbeta]
DECIPHER (Syndromes)8:39442087-39469094  ENSG00000168619
CONAN: Copy Number AnalysisADAM18 
Mutations
ICGC Data PortalADAM18 
TCGA Data PortalADAM18 
Broad Tumor PortalADAM18
OASIS PortalADAM18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAM18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAM18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAM18
DgiDB (Drug Gene Interaction Database)ADAM18
DoCM (Curated mutations)ADAM18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAM18 (select a term)
intoGenADAM18
Cancer3DADAM18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenADAM18
Genetic Testing Registry ADAM18
NextProtQ9Y3Q7 [Medical]
TSGene8749
GENETestsADAM18
Huge Navigator ADAM18 [HugePedia]
snp3D : Map Gene to Disease8749
BioCentury BCIQADAM18
ClinGenADAM18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8749
Chemical/Pharm GKB GenePA24513
Clinical trialADAM18
Miscellaneous
canSAR (ICR)ADAM18 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAM18
EVEXADAM18
GoPubMedADAM18
iHOPADAM18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:54:49 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.