Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ADAM19 (ADAM metallopeptidase domain 19)

Identity

Alias_namesa disintegrin and metalloproteinase domain 19 (meltrin beta)
Alias_symbol (synonym)MLTNB
Other aliasFKSG34
MADDAM
HGNC (Hugo) ADAM19
LocusID (NCBI) 8728
Atlas_Id 46837
Location 5q33.3  [Link to chromosome band 5q33]
Location_base_pair Starts at 157477304 and ends at 157575823 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADAM19 (5q33.3) / HPD (12q24.31)CCDC14 (3q21.1) / ADAM19 (5q33.3)TTC33 (5p13.1) / ADAM19 (5q33.3)
CCDC14 3q21.1 / ADAM19 5q33.3TTC33 5p13.1 / ADAM19 5q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAM19   197
Cards
Entrez_Gene (NCBI)ADAM19  8728  ADAM metallopeptidase domain 19
AliasesFKSG34; MADDAM; MLTNB
GeneCards (Weizmann)ADAM19
Ensembl hg19 (Hinxton)ENSG00000135074 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135074 [Gene_View]  chr5:157477304-157575823 [Contig_View]  ADAM19 [Vega]
ICGC DataPortalENSG00000135074
TCGA cBioPortalADAM19
AceView (NCBI)ADAM19
Genatlas (Paris)ADAM19
WikiGenes8728
SOURCE (Princeton)ADAM19
Genetics Home Reference (NIH)ADAM19
Genomic and cartography
GoldenPath hg38 (UCSC)ADAM19  -     chr5:157477304-157575823 -  5q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAM19  -     5q33.3   [Description]    (hg19-Feb_2009)
EnsemblADAM19 - 5q33.3 [CytoView hg19]  ADAM19 - 5q33.3 [CytoView hg38]
Mapping of homologs : NCBIADAM19 [Mapview hg19]  ADAM19 [Mapview hg38]
OMIM603640   
Gene and transcription
Genbank (Entrez)AF134707 AF311317 AF326918 AK091464 AK093535
RefSeq transcript (Entrez)NM_023038 NM_033274
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAM19
Cluster EST : UnigeneHs.483944 [ NCBI ]
CGAP (NCI)Hs.483944
Alternative Splicing GalleryENSG00000135074
Gene ExpressionADAM19 [ NCBI-GEO ]   ADAM19 [ EBI - ARRAY_EXPRESS ]   ADAM19 [ SEEK ]   ADAM19 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAM19 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8728
GTEX Portal (Tissue expression)ADAM19
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H013   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H013  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H013
Splice isoforms : SwissVarQ9H013
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9H013
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)    EGF_2 (PS01186)    EGF_3 (PS50026)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM19    ADAM_Cys-rich    Disintegrin_CS    Disintegrin_dom    EGF-like_CS    EGF-like_dom    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_N    Reprolysin_adamalysin   
Domain families : Pfam (Sanger)ADAM_CR (PF08516)    Disintegrin (PF00200)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)   
Domain families : Pfam (NCBI)pfam08516    pfam00200    pfam01562    pfam01421   
Domain families : Smart (EMBL)ACR (SM00608)  DISIN (SM00050)  
Conserved Domain (NCBI)ADAM19
DMDM Disease mutations8728
Blocks (Seattle)ADAM19
SuperfamilyQ9H013
Human Protein AtlasENSG00000135074
Peptide AtlasQ9H013
HPRD04704
IPIIPI00941096   IPI00249735   IPI00902539   IPI00974244   IPI00979854   
Protein Interaction databases
DIP (DOE-UCLA)Q9H013
IntAct (EBI)Q9H013
FunCoupENSG00000135074
BioGRIDADAM19
STRING (EMBL)ADAM19
ZODIACADAM19
Ontologies - Pathways
QuickGOQ9H013
Ontology : AmiGOmetalloendopeptidase activity  Golgi apparatus  membrane protein ectodomain proteolysis  heart development  integral component of membrane  SH3 domain binding  metal ion binding  
Ontology : EGO-EBImetalloendopeptidase activity  Golgi apparatus  membrane protein ectodomain proteolysis  heart development  integral component of membrane  SH3 domain binding  metal ion binding  
NDEx NetworkADAM19
Atlas of Cancer Signalling NetworkADAM19
Wikipedia pathwaysADAM19
Orthology - Evolution
OrthoDB8728
GeneTree (enSembl)ENSG00000135074
Phylogenetic Trees/Animal Genes : TreeFamADAM19
HOVERGENQ9H013
HOGENOMQ9H013
Homologs : HomoloGeneADAM19
Homology/Alignments : Family Browser (UCSC)ADAM19
Gene fusions - Rearrangements
Fusion : MitelmanCCDC14/ADAM19 [3q21.1/5q33.3]  [t(3;5)(q21;q33)]  
Fusion : MitelmanTTC33/ADAM19 [5p13.1/5q33.3]  [t(5;5)(p13;q33)]  
Fusion: TCGACCDC14 3q21.1 ADAM19 5q33.3 BRCA
Fusion: TCGATTC33 5p13.1 ADAM19 5q33.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAM19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAM19
dbVarADAM19
ClinVarADAM19
1000_GenomesADAM19 
Exome Variant ServerADAM19
ExAC (Exome Aggregation Consortium)ADAM19 (select the gene name)
Genetic variants : HAPMAP8728
Genomic Variants (DGV)ADAM19 [DGVbeta]
DECIPHERADAM19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAM19 
Mutations
ICGC Data PortalADAM19 
TCGA Data PortalADAM19 
Broad Tumor PortalADAM19
OASIS PortalADAM19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAM19  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAM19
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAM19
DgiDB (Drug Gene Interaction Database)ADAM19
DoCM (Curated mutations)ADAM19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAM19 (select a term)
intoGenADAM19
Cancer3DADAM19(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603640   
Orphanet
MedgenADAM19
Genetic Testing Registry ADAM19
NextProtQ9H013 [Medical]
TSGene8728
GENETestsADAM19
Huge Navigator ADAM19 [HugePedia]
snp3D : Map Gene to Disease8728
BioCentury BCIQADAM19
ClinGenADAM19
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8728
Chemical/Pharm GKB GenePA24514
Clinical trialADAM19
Miscellaneous
canSAR (ICR)ADAM19 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAM19
EVEXADAM19
GoPubMedADAM19
iHOPADAM19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:04:57 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.