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ADAM2 (ADAM metallopeptidase domain 2)

Identity

Alias_namesFTNB
fertilin beta
Alias_symbol (synonym)PH-30b
PH30
CT15
Other aliasCRYN1
CRYN2
PH30-beta
HGNC (Hugo) ADAM2
LocusID (NCBI) 2515
Atlas_Id 47076
Location 8p11.22  [Link to chromosome band 8p11]
Location_base_pair Starts at 39601255 and ends at 39695808 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADAM2 (8p11.22) / MTMR2 (11q21)CPT1A (11q13.3) / ADAM2 (8p11.22)HIRA (22q11.21) / ADAM2 (8p11.22)
KAT6A (8p11.21) / ADAM2 (8p11.22)ADAM2 8p11.22 / MTMR2 11q21CPT1A 11q13.3 / ADAM2 8p11.22
HIRA 22q11.21 / ADAM2 8p11.22KAT6A 8p11.21 / ADAM2 8p11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAM2   198
Cards
Entrez_Gene (NCBI)ADAM2  2515  ADAM metallopeptidase domain 2
AliasesCRYN1; CRYN2; CT15; FTNB; 
PH-30b; PH30; PH30-beta
GeneCards (Weizmann)ADAM2
Ensembl hg19 (Hinxton)ENSG00000104755 [Gene_View]  chr8:39601255-39695808 [Contig_View]  ADAM2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000104755 [Gene_View]  chr8:39601255-39695808 [Contig_View]  ADAM2 [Vega]
ICGC DataPortalENSG00000104755
TCGA cBioPortalADAM2
AceView (NCBI)ADAM2
Genatlas (Paris)ADAM2
WikiGenes2515
SOURCE (Princeton)ADAM2
Genetics Home Reference (NIH)ADAM2
Genomic and cartography
GoldenPath hg19 (UCSC)ADAM2  -     chr8:39601255-39695808 -  8p11.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADAM2  -     8p11.22   [Description]    (hg38-Dec_2013)
EnsemblADAM2 - 8p11.22 [CytoView hg19]  ADAM2 - 8p11.22 [CytoView hg38]
Mapping of homologs : NCBIADAM2 [Mapview hg19]  ADAM2 [Mapview hg38]
OMIM601533   
Gene and transcription
Genbank (Entrez)AJ133005 AK301734 BC034957 BC064547 BG719616
RefSeq transcript (Entrez)NM_001278113 NM_001278114 NM_001464
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_167187 NT_187577 NW_004929337
Consensus coding sequences : CCDS (NCBI)ADAM2
Cluster EST : UnigeneHs.177959 [ NCBI ]
CGAP (NCI)Hs.177959
Alternative Splicing GalleryENSG00000104755
Gene ExpressionADAM2 [ NCBI-GEO ]   ADAM2 [ EBI - ARRAY_EXPRESS ]   ADAM2 [ SEEK ]   ADAM2 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2515
GTEX Portal (Tissue expression)ADAM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99965   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99965  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99965
Splice isoforms : SwissVarQ99965
PhosPhoSitePlusQ99965
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)   
Domains : Interpro (EBI)ADAM_Cys-rich    Disintegrin_CS    Disintegrin_dom    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_N   
Domain families : Pfam (Sanger)ADAM_CR (PF08516)    Disintegrin (PF00200)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)   
Domain families : Pfam (NCBI)pfam08516    pfam00200    pfam01562    pfam01421   
Domain families : Smart (EMBL)ACR (SM00608)  DISIN (SM00050)  
Conserved Domain (NCBI)ADAM2
DMDM Disease mutations2515
Blocks (Seattle)ADAM2
SuperfamilyQ99965
Human Protein AtlasENSG00000104755
Peptide AtlasQ99965
HPRD03322
IPIIPI00019173   IPI00216374   IPI00440167   IPI00909531   
Protein Interaction databases
DIP (DOE-UCLA)Q99965
IntAct (EBI)Q99965
FunCoupENSG00000104755
BioGRIDADAM2
STRING (EMBL)ADAM2
ZODIACADAM2
Ontologies - Pathways
QuickGOQ99965
Ontology : AmiGOmetalloendopeptidase activity  integrin binding  plasma membrane  integral component of plasma membrane  proteolysis  cell adhesion  binding of sperm to zona pellucida  fusion of sperm to egg plasma membrane  metallopeptidase activity  zinc ion binding  visual learning  cell surface  adult behavior  
Ontology : EGO-EBImetalloendopeptidase activity  integrin binding  plasma membrane  integral component of plasma membrane  proteolysis  cell adhesion  binding of sperm to zona pellucida  fusion of sperm to egg plasma membrane  metallopeptidase activity  zinc ion binding  visual learning  cell surface  adult behavior  
NDEx NetworkADAM2
Atlas of Cancer Signalling NetworkADAM2
Wikipedia pathwaysADAM2
Orthology - Evolution
OrthoDB2515
GeneTree (enSembl)ENSG00000104755
Phylogenetic Trees/Animal Genes : TreeFamADAM2
HOVERGENQ99965
HOGENOMQ99965
Homologs : HomoloGeneADAM2
Homology/Alignments : Family Browser (UCSC)ADAM2
Gene fusions - Rearrangements
Fusion : MitelmanADAM2/MTMR2 [8p11.22/11q21]  
Fusion : MitelmanCPT1A/ADAM2 [11q13.3/8p11.22]  [t(8;11)(p11;q13)]  
Fusion : MitelmanHIRA/ADAM2 [22q11.21/8p11.22]  [t(8;22)(p11;q11)]  
Fusion : MitelmanKAT6A/ADAM2 [8p11.21/8p11.22]  [t(8;8)(p11;p11)]  
Fusion: TCGAADAM2 8p11.22 MTMR2 11q21 LUAD
Fusion: TCGACPT1A 11q13.3 ADAM2 8p11.22 BRCA
Fusion: TCGAHIRA 22q11.21 ADAM2 8p11.22 LUAD
Fusion: TCGAKAT6A 8p11.21 ADAM2 8p11.22 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAM2
dbVarADAM2
ClinVarADAM2
1000_GenomesADAM2 
Exome Variant ServerADAM2
ExAC (Exome Aggregation Consortium)ADAM2 (select the gene name)
Genetic variants : HAPMAP2515
Genomic Variants (DGV)ADAM2 [DGVbeta]
DECIPHER (Syndromes)8:39601255-39695808  ENSG00000104755
CONAN: Copy Number AnalysisADAM2 
Mutations
ICGC Data PortalADAM2 
TCGA Data PortalADAM2 
Broad Tumor PortalADAM2
OASIS PortalADAM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAM2
DgiDB (Drug Gene Interaction Database)ADAM2
DoCM (Curated mutations)ADAM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAM2 (select a term)
intoGenADAM2
Cancer3DADAM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601533   
Orphanet
MedgenADAM2
Genetic Testing Registry ADAM2
NextProtQ99965 [Medical]
TSGene2515
GENETestsADAM2
Huge Navigator ADAM2 [HugePedia]
snp3D : Map Gene to Disease2515
BioCentury BCIQADAM2
ClinGenADAM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2515
Chemical/Pharm GKB GenePA24515
Clinical trialADAM2
Miscellaneous
canSAR (ICR)ADAM2 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAM2
EVEXADAM2
GoPubMedADAM2
iHOPADAM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:51:32 CEST 2017

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