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ADAM21 (ADAM metallopeptidase domain 21)

Identity

Alias_namesa disintegrin and metalloproteinase domain 21
Alias_symbol (synonym)ADAM31
Other aliasADAM 21
HGNC (Hugo) ADAM21
LocusID (NCBI) 8747
Atlas_Id 60134
Location 14q24.2  [Link to chromosome band 14q24]
Location_base_pair Starts at 70452157 and ends at 70459905 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAM21   200
Cards
Entrez_Gene (NCBI)ADAM21  8747  ADAM metallopeptidase domain 21
AliasesADAM; ADAM31
GeneCards (Weizmann)ADAM21
Ensembl hg19 (Hinxton)ENSG00000139985 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139985 [Gene_View]  chr14:70452157-70459905 [Contig_View]  ADAM21 [Vega]
ICGC DataPortalENSG00000139985
TCGA cBioPortalADAM21
AceView (NCBI)ADAM21
Genatlas (Paris)ADAM21
WikiGenes8747
SOURCE (Princeton)ADAM21
Genetics Home Reference (NIH)ADAM21
Genomic and cartography
GoldenPath hg38 (UCSC)ADAM21  -     chr14:70452157-70459905 +  14q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAM21  -     14q24.2   [Description]    (hg19-Feb_2009)
EnsemblADAM21 - 14q24.2 [CytoView hg19]  ADAM21 - 14q24.2 [CytoView hg38]
Mapping of homologs : NCBIADAM21 [Mapview hg19]  ADAM21 [Mapview hg38]
OMIM603713   
Gene and transcription
Genbank (Entrez)AA758110 AF029900 BC109024 BC109025 DB035527
RefSeq transcript (Entrez)NM_003813
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAM21
Cluster EST : UnigeneHs.178748 [ NCBI ]
CGAP (NCI)Hs.178748
Alternative Splicing GalleryENSG00000139985
Gene ExpressionADAM21 [ NCBI-GEO ]   ADAM21 [ EBI - ARRAY_EXPRESS ]   ADAM21 [ SEEK ]   ADAM21 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAM21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8747
GTEX Portal (Tissue expression)ADAM21
Human Protein AtlasENSG00000139985-ADAM21 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKJ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKJ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKJ8
Splice isoforms : SwissVarQ9UKJ8
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9UKJ8
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)    EGF_2 (PS01186)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM_Cys-rich    Disintegrin_CS    Disintegrin_dom    EGF-like_CS    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_N    Reprolysin_adamalysin   
Domain families : Pfam (Sanger)ADAM_CR (PF08516)    Disintegrin (PF00200)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)   
Domain families : Pfam (NCBI)pfam08516    pfam00200    pfam01562    pfam01421   
Domain families : Smart (EMBL)ACR (SM00608)  DISIN (SM00050)  
Conserved Domain (NCBI)ADAM21
DMDM Disease mutations8747
Blocks (Seattle)ADAM21
SuperfamilyQ9UKJ8
Human Protein Atlas [tissue]ENSG00000139985-ADAM21 [tissue]
Peptide AtlasQ9UKJ8
HPRD04755
IPIIPI00007596   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKJ8
IntAct (EBI)Q9UKJ8
FunCoupENSG00000139985
BioGRIDADAM21
STRING (EMBL)ADAM21
ZODIACADAM21
Ontologies - Pathways
QuickGOQ9UKJ8
Ontology : AmiGOmetalloendopeptidase activity  plasma membrane  proteolysis  single fertilization  binding of sperm to zona pellucida  metallopeptidase activity  integral component of membrane  axon  neuronal cell body  metal ion binding  
Ontology : EGO-EBImetalloendopeptidase activity  plasma membrane  proteolysis  single fertilization  binding of sperm to zona pellucida  metallopeptidase activity  integral component of membrane  axon  neuronal cell body  metal ion binding  
NDEx NetworkADAM21
Atlas of Cancer Signalling NetworkADAM21
Wikipedia pathwaysADAM21
Orthology - Evolution
OrthoDB8747
GeneTree (enSembl)ENSG00000139985
Phylogenetic Trees/Animal Genes : TreeFamADAM21
HOVERGENQ9UKJ8
HOGENOMQ9UKJ8
Homologs : HomoloGeneADAM21
Homology/Alignments : Family Browser (UCSC)ADAM21
Gene fusions - Rearrangements
Tumor Fusion PortalADAM21
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAM21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAM21
dbVarADAM21
ClinVarADAM21
1000_GenomesADAM21 
Exome Variant ServerADAM21
ExAC (Exome Aggregation Consortium)ENSG00000139985
GNOMAD BrowserENSG00000139985
Genetic variants : HAPMAP8747
Genomic Variants (DGV)ADAM21 [DGVbeta]
DECIPHERADAM21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAM21 
Mutations
ICGC Data PortalADAM21 
TCGA Data PortalADAM21 
Broad Tumor PortalADAM21
OASIS PortalADAM21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAM21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAM21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAM21
DgiDB (Drug Gene Interaction Database)ADAM21
DoCM (Curated mutations)ADAM21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAM21 (select a term)
intoGenADAM21
Cancer3DADAM21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603713   
Orphanet
DisGeNETADAM21
MedgenADAM21
Genetic Testing Registry ADAM21
NextProtQ9UKJ8 [Medical]
TSGene8747
GENETestsADAM21
Target ValidationADAM21
Huge Navigator ADAM21 [HugePedia]
snp3D : Map Gene to Disease8747
BioCentury BCIQADAM21
ClinGenADAM21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8747
Chemical/Pharm GKB GenePA24517
Clinical trialADAM21
Miscellaneous
canSAR (ICR)ADAM21 (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAM21
EVEXADAM21
GoPubMedADAM21
iHOPADAM21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:29:11 CET 2017

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