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ADAM28 (ADAM metallopeptidase domain 28)

Identity

Alias_namesa disintegrin and metalloproteinase domain 28
Alias_symbol (synonym)eMDCII
MDC-Lm
MDC-Ls
ADAM23
Other aliasADAM 28
MDC-L
MDCL
eMDC II
HGNC (Hugo) ADAM28
LocusID (NCBI) 10863
Atlas_Id 53088
Location 8p21.2  [Link to chromosome band 8p21]
Location_base_pair Starts at 24151553 and ends at 24216531 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADAM28 (8p21.2) / ADAM28 (8p21.2)CDCA2 (8p21.2) / ADAM28 (8p21.2)TMEM55A (8q21.3) / ADAM28 (8p21.2)
CDCA2 8p21.2 / ADAM28 8p21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAM28   206
Cards
Entrez_Gene (NCBI)ADAM28  10863  ADAM metallopeptidase domain 28
AliasesADAM; MDC-L; MDCL; eMDC; 
eMDCII
GeneCards (Weizmann)ADAM28
Ensembl hg19 (Hinxton)ENSG00000042980 [Gene_View]  chr8:24151553-24216531 [Contig_View]  ADAM28 [Vega]
Ensembl hg38 (Hinxton)ENSG00000042980 [Gene_View]  chr8:24151553-24216531 [Contig_View]  ADAM28 [Vega]
ICGC DataPortalENSG00000042980
TCGA cBioPortalADAM28
AceView (NCBI)ADAM28
Genatlas (Paris)ADAM28
WikiGenes10863
SOURCE (Princeton)ADAM28
Genetics Home Reference (NIH)ADAM28
Genomic and cartography
GoldenPath hg19 (UCSC)ADAM28  -     chr8:24151553-24216531 +  8p21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADAM28  -     8p21.2   [Description]    (hg38-Dec_2013)
EnsemblADAM28 - 8p21.2 [CytoView hg19]  ADAM28 - 8p21.2 [CytoView hg38]
Mapping of homologs : NCBIADAM28 [Mapview hg19]  ADAM28 [Mapview hg38]
OMIM606188   
Gene and transcription
Genbank (Entrez)AF137334 AF137335 AI475787 AI624552 AJ242015
RefSeq transcript (Entrez)NM_001304351 NM_014265 NM_021777
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_029394 NT_167187 NW_004929337
Consensus coding sequences : CCDS (NCBI)ADAM28
Cluster EST : UnigeneHs.388903 [ NCBI ]
CGAP (NCI)Hs.388903
Alternative Splicing GalleryENSG00000042980
Gene ExpressionADAM28 [ NCBI-GEO ]   ADAM28 [ EBI - ARRAY_EXPRESS ]   ADAM28 [ SEEK ]   ADAM28 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAM28 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10863
GTEX Portal (Tissue expression)ADAM28
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKQ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKQ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKQ2
Splice isoforms : SwissVarQ9UKQ2
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9UKQ2
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)    EGF_2 (PS01186)    EGF_3 (PS50026)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM_Cys-rich    Disintegrin_CS    Disintegrin_dom    EGF-like_CS    EGF-like_dom    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_N   
Domain families : Pfam (Sanger)ADAM_CR (PF08516)    Disintegrin (PF00200)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)   
Domain families : Pfam (NCBI)pfam08516    pfam00200    pfam01562    pfam01421   
Domain families : Smart (EMBL)ACR (SM00608)  DISIN (SM00050)  EGF (SM00181)  
Conserved Domain (NCBI)ADAM28
DMDM Disease mutations10863
Blocks (Seattle)ADAM28
SuperfamilyQ9UKQ2
Human Protein AtlasENSG00000042980
Peptide AtlasQ9UKQ2
HPRD08391
IPIIPI00007709   IPI00029097   IPI01010046   IPI00909497   IPI00983328   IPI00973907   IPI01011774   IPI00983698   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKQ2
IntAct (EBI)Q9UKQ2
FunCoupENSG00000042980
BioGRIDADAM28
STRING (EMBL)ADAM28
ZODIACADAM28
Ontologies - Pathways
QuickGOQ9UKQ2
Ontology : AmiGOmetalloendopeptidase activity  extracellular region  plasma membrane  proteolysis  spermatogenesis  metallopeptidase activity  zinc ion binding  integral component of membrane  
Ontology : EGO-EBImetalloendopeptidase activity  extracellular region  plasma membrane  proteolysis  spermatogenesis  metallopeptidase activity  zinc ion binding  integral component of membrane  
NDEx NetworkADAM28
Atlas of Cancer Signalling NetworkADAM28
Wikipedia pathwaysADAM28
Orthology - Evolution
OrthoDB10863
GeneTree (enSembl)ENSG00000042980
Phylogenetic Trees/Animal Genes : TreeFamADAM28
HOVERGENQ9UKQ2
HOGENOMQ9UKQ2
Homologs : HomoloGeneADAM28
Homology/Alignments : Family Browser (UCSC)ADAM28
Gene fusions - Rearrangements
Fusion : MitelmanCDCA2/ADAM28 [8p21.2/8p21.2]  [t(8;8)(p21;p21)]  
Fusion: TCGACDCA2 8p21.2 ADAM28 8p21.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAM28 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAM28
dbVarADAM28
ClinVarADAM28
1000_GenomesADAM28 
Exome Variant ServerADAM28
ExAC (Exome Aggregation Consortium)ADAM28 (select the gene name)
Genetic variants : HAPMAP10863
Genomic Variants (DGV)ADAM28 [DGVbeta]
DECIPHER (Syndromes)8:24151553-24216531  ENSG00000042980
CONAN: Copy Number AnalysisADAM28 
Mutations
ICGC Data PortalADAM28 
TCGA Data PortalADAM28 
Broad Tumor PortalADAM28
OASIS PortalADAM28 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAM28  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAM28
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAM28
DgiDB (Drug Gene Interaction Database)ADAM28
DoCM (Curated mutations)ADAM28 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAM28 (select a term)
intoGenADAM28
Cancer3DADAM28(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606188   
Orphanet
MedgenADAM28
Genetic Testing Registry ADAM28
NextProtQ9UKQ2 [Medical]
TSGene10863
GENETestsADAM28
Huge Navigator ADAM28 [HugePedia]
snp3D : Map Gene to Disease10863
BioCentury BCIQADAM28
ClinGenADAM28
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10863
Chemical/Pharm GKB GenePA24523
Clinical trialADAM28
Miscellaneous
canSAR (ICR)ADAM28 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAM28
EVEXADAM28
GoPubMedADAM28
iHOPADAM28
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:54:50 CET 2017

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