ADAM28 (ADAM metallopeptidase domain 28)

Identity

Other names	ADAM23
	MDC-Lm
	MDC-Ls
	MDCL
	eMDCII
HGNC	ADAM28
Location	8p21.2
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ADAM28   206
Entrez_Gene	ADAM28  10863  ADAM metallopeptidase domain 28
	Cards
GeneCards	ADAM28
Ensembl	ADAM28 [Search_View]   ENSG00000042980 [Gene_View]
Genatlas	ADAM28
GeneLynx	ADAM28
eGenome	ADAM28
euGene	10863
	Genomic and cartography
GoldenPath	ADAM28  -  8p21.2   chr8:24207525-24268671 +  8p21.2   [Description]    (hg18-March_2006)
Ensembl	ADAM28 - 8p21.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ADAM28
	Gene and transcription
Genbank	AF137334 [ ENTREZ ]
Genbank	AF137335 [ ENTREZ ]
Genbank	AI475787 [ ENTREZ ]
Genbank	AI624552 [ ENTREZ ]
Genbank	AJ242015 [ ENTREZ ]
RefSeq	NM_014265 [ SRS ]    NM_014265 [ ENTREZ ]
RefSeq	NM_021777 [ SRS ]    NM_021777 [ ENTREZ ]
RefSeq	AC_000051 [ SRS ]    AC_000051 [ ENTREZ ]
RefSeq	AC_000140 [ SRS ]    AC_000140 [ ENTREZ ]
RefSeq	NC_000008 [ SRS ]    NC_000008 [ ENTREZ ]
RefSeq	NT_023666 [ SRS ]    NT_023666 [ ENTREZ ]
RefSeq	NW_001839127 [ SRS ]    NW_001839127 [ ENTREZ ]
RefSeq	NW_923907 [ SRS ]    NW_923907 [ ENTREZ ]
AceView	ADAM28 AceView - NCBI
Unigene	Hs.174030 [ SRS ]    Hs.174030 [ NCBI ]     HS174030 [ spliceNest ]
Fast-db	2743 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q9UKQ2 [ SRS]    Q9UKQ2 [ EXPASY ]     Q9UKQ2 [ INTERPRO ]     Q9UKQ2 [ UNIPROT ]
Prosite	PS50215 ADAM_MEPRO [ SRS ]    PS50215 ADAM_MEPRO [ Expasy ]
Prosite	PS00546 CYSTEINE_SWITCH [ SRS ]    PS00546 CYSTEINE_SWITCH [ Expasy ]
Prosite	PS00427 DISINTEGRIN_1 [ SRS ]    PS00427 DISINTEGRIN_1 [ Expasy ]
Prosite	PS50214 DISINTEGRIN_2 [ SRS ]    PS50214 DISINTEGRIN_2 [ Expasy ]
Prosite	PS00022 EGF_1 [ SRS ]    PS00022 EGF_1 [ Expasy ]
Prosite	PS01186 EGF_2 [ SRS ]    PS01186 EGF_2 [ Expasy ]
Prosite	PS50026 EGF_3 [ SRS ]    PS50026 EGF_3 [ Expasy ]
Prosite	PS00142 ZINC_PROTEASE [ SRS ]    PS00142 ZINC_PROTEASE [ Expasy ]
Interpro	IPR006586 ADAM_cysteine [ SRS ]    IPR006586 ADAM_cysteine [ EBI ]
Interpro	IPR001762 Blood-coag_inhib_Disintegrin [ SRS ]    IPR001762 Blood-coag_inhib_Disintegrin [ EBI ]
Interpro	IPR006210 EGF [ SRS ]    IPR006210 EGF [ EBI ]
Interpro	IPR000742 EGF_3 [ SRS ]    IPR000742 EGF_3 [ EBI ]
Interpro	IPR013032 EGF_like_reg_CS [ SRS ]    IPR013032 EGF_like_reg_CS [ EBI ]
Interpro	IPR001818 Pept_M10A_M12B [ SRS ]    IPR001818 Pept_M10A_M12B [ EBI ]
Interpro	IPR006025 Pept_M_Zn_BS [ SRS ]    IPR006025 Pept_M_Zn_BS [ EBI ]
Interpro	IPR001590 Peptidase_M12B [ SRS ]    IPR001590 Peptidase_M12B [ EBI ]
Interpro	IPR002870 Peptidase_M12B_N [ SRS ]    IPR002870 Peptidase_M12B_N [ EBI ]
CluSTr	Q9UKQ2
Pfam	PF08516 ADAM_CR [ SRS ]    PF08516 ADAM_CR [ Sanger ]    pfam08516 [ NCBI-CDD ]
Pfam	PF00200 Disintegrin [ SRS ]    PF00200 Disintegrin [ Sanger ]    pfam00200 [ NCBI-CDD ]
Pfam	PF01562 Pep_M12B_propep [ SRS ]    PF01562 Pep_M12B_propep [ Sanger ]    pfam01562 [ NCBI-CDD ]
Pfam	PF01421 Reprolysin [ SRS ]    PF01421 Reprolysin [ Sanger ]    pfam01421 [ NCBI-CDD ]
Smart	SM00608 ACR [EMBL]
Smart	SM00050 DISIN [EMBL]
Smart	SM00181 EGF [EMBL]
Prodom	PD000664 Disintegrin[INRA-Toulouse]
Prodom	Q9UKQ2 ADA28_HUMAN [ Domain structure ]   Q9UKQ2 ADA28_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q9UKQ2
HPRD	08391
	Protein Interaction databases
DIP	Q9UKQ2
IntAct	Q9UKQ2
	Polymorphism : SNP, mutations, diseases
OMIM	606188    [ map ]
GENECLINICS	606188
SNP	ADAM28 [dbSNP-NCBI]
SNP	NM_014265 [SNP-NCI]
SNP	NM_021777 [SNP-NCI]
SNP	ADAM28 [GeneSNPs - Utah]  ADAM28] [HGBASE - SRS]
HAPMAP	ADAM28 [HAPMAP]
COSMIC	ADAM28 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ADAM28
	General knowledge
Family Browser	ADAM28 [UCSC Family Browser]
SOURCE	NM_014265
SOURCE	NM_021777
SMD	Hs.174030
SAGE	Hs.174030
Enzyme	3.4.24.- [ Enzyme-Expasy ]   3.4.24.- [ Enzyme-SRS ]   3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   3.4.24.- [ WIT ]
GO	metalloendopeptidase activity [Amigo]  metalloendopeptidase activity
GO	extracellular region [Amigo]  extracellular region
GO	plasma membrane [Amigo]  plasma membrane
GO	proteolysis [Amigo]  proteolysis
GO	spermatogenesis [Amigo]  spermatogenesis
GO	zinc ion binding [Amigo]  zinc ion binding
GO	integral to membrane [Amigo]  integral to membrane
GO	metal ion binding [Amigo]  metal ion binding
PubGene	ADAM28
TreeFam	ADAM28
CTD	10863 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ADAM28 Related clones (RZPD - Berlin)
	PubMed
PubMed	10 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 19:58:55 2008