ADAM28 (ADAM metallopeptidase domain 28)

2012-12-01  

Identity

HGNC
ADAM28
LOCATION
8p21.2
LOCUSID
10863
ALIAS
ADAM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10863
MIM: 606188
HGNC: 206
Ensembl: ENSG00000042980

Variants:

dbSNP: 10863
ClinVar: 10863
TCGA: ENSG00000042980
COSMIC: ADAM28

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000042980ENST00000265769Q9UKQ2
ENSG00000042980ENST00000437154Q9UKQ2
ENSG00000042980ENST00000437154A0A384NKT9
ENSG00000042980ENST00000518326H0YBQ8
ENSG00000042980ENST00000520448E5RGY1
ENSG00000042980ENST00000521629H0YBG8
ENSG00000042980ENST00000523379E5RJQ1

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
127773992003Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23.43
170470532006ADAM28 is overexpressed in human breast carcinomas: implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3.33
226368002012Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor.25
160525212006ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis.18
190545712009Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.18
276611262016MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28.13
175970692007Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells.12
209710632010Connective tissue growth factor is a substrate of ADAM28.10
217827982011Characterization of ADAM28 as a biomarker of bladder transitional cell carcinomas by urinary proteome analysis.9
205448432010ADAM28: a potential oncogene involved in asbestos-related lung adenocarcinomas.8

Citation

Dessen P

ADAM28 (ADAM metallopeptidase domain 28)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53088/adam28