Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ADAM8 (ADAM metallopeptidase domain 8)

Identity

Alias_namesa disintegrin and metalloproteinase domain 8
Alias_symbol (synonym)CD156
MS2
CD156a
Other alias
HGNC (Hugo) ADAM8
LocusID (NCBI) 101
Atlas_Id 43603
Location 10q26.3  [Link to chromosome band 10q26]
Location_base_pair Starts at 133262416 and ends at 133276903 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAM8 (10q26.3) / ADAM8 (10q26.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ADAM8   215
Cards
Entrez_Gene (NCBI)ADAM8  101  ADAM metallopeptidase domain 8
AliasesCD156; CD156a; MS2
GeneCards (Weizmann)ADAM8
Ensembl hg19 (Hinxton)ENSG00000151651 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151651 [Gene_View]  ENSG00000151651 [Sequence]  chr10:133262416-133276903 [Contig_View]  ADAM8 [Vega]
ICGC DataPortalENSG00000151651
TCGA cBioPortalADAM8
AceView (NCBI)ADAM8
Genatlas (Paris)ADAM8
WikiGenes101
SOURCE (Princeton)ADAM8
Genetics Home Reference (NIH)ADAM8
Genomic and cartography
GoldenPath hg38 (UCSC)ADAM8  -     chr10:133262416-133276903 -  10q26.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAM8  -     10q26.3   [Description]    (hg19-Feb_2009)
ADAM8 - 10q26.3 [CytoView hg19]  ADAM8 - 10q26.3 [CytoView hg38]
Mapping of homologs : NCBIADAM8 [Mapview hg19]  ADAM8 [Mapview hg38]
OMIM602267   
Gene and transcription
Genbank (Entrez)AK301147 AK304324 AK310662 AK312834 BC064500
RefSeq transcript (Entrez)NM_001109 NM_001164489 NM_001164490
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAM8
Cluster EST : UnigeneHs.501574 [ NCBI ]
CGAP (NCI)Hs.501574
Alternative Splicing GalleryENSG00000151651
Gene ExpressionADAM8 [ NCBI-GEO ]   ADAM8 [ EBI - ARRAY_EXPRESS ]   ADAM8 [ SEEK ]   ADAM8 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAM8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)101
GTEX Portal (Tissue expression)ADAM8
Human Protein AtlasENSG00000151651-ADAM8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78325   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78325  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78325
Splice isoforms : SwissVarP78325
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusP78325
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)    EGF_2 (PS01186)    EGF_3 (PS50026)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM_Cys-rich    Disintegrin_CS    Disintegrin_dom    Disintegrin_dom_sf    EGF-like_CS    EGF-like_dom    MetalloPept_cat_dom_sf    Peptidase_M12B    Peptidase_M12B_N    Reprolysin_adamalysin   
Domain families : Pfam (Sanger)ADAM_CR (PF08516)    Disintegrin (PF00200)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)   
Domain families : Pfam (NCBI)pfam08516    pfam00200    pfam01562    pfam01421   
Domain families : Smart (EMBL)ACR (SM00608)  DISIN (SM00050)  
Conserved Domain (NCBI)ADAM8
DMDM Disease mutations101
Blocks (Seattle)ADAM8
PDB (RSDB)4DD8   
PDB Europe4DD8   
PDB (PDBSum)4DD8   
PDB (IMB)4DD8   
Structural Biology KnowledgeBase4DD8   
SCOP (Structural Classification of Proteins)4DD8   
CATH (Classification of proteins structures)4DD8   
SuperfamilyP78325
Human Protein Atlas [tissue]ENSG00000151651-ADAM8 [tissue]
Peptide AtlasP78325
HPRD03777
IPIIPI00019158   IPI00944573   IPI00910688   
Protein Interaction databases
DIP (DOE-UCLA)P78325
IntAct (EBI)P78325
FunCoupENSG00000151651
BioGRIDADAM8
STRING (EMBL)ADAM8
ZODIACADAM8
Ontologies - Pathways
QuickGOP78325
Ontology : AmiGOcell morphogenesis  angiogenesis  podosome  leukocyte migration involved in inflammatory response  positive regulation of acute inflammatory response  metalloendopeptidase activity  serine-type endopeptidase activity  calcium ion binding  protein binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  proteolysis  inflammatory response  metallopeptidase activity  zinc ion binding  cell surface  positive regulation of protein processing  regulation of cell-cell adhesion  extracellular matrix disassembly  phagolysosome  dense core granule membrane  positive regulation of T cell differentiation in thymus  specific granule membrane  specific granule  neutrophil degranulation  positive regulation of MAP kinase activity  negative regulation of neuron apoptotic process  protein self-association  positive regulation of innate immune response  positive regulation of bone resorption  positive regulation of cell adhesion  lymphocyte chemotaxis  positive regulation of protein secretion  cell adhesion molecule binding  positive regulation of membrane protein ectodomain proteolysis  positive regulation of NF-kappaB transcription factor activity  positive regulation of protein kinase B signaling  positive regulation of thymocyte apoptotic process  tertiary granule  tertiary granule membrane  alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex  alpha9-beta1 integrin-ADAM8 complex  cellular response to hypoxia  cell-cell adhesion  ficolin-1-rich granule membrane  positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  positive regulation of neutrophil extravasation  positive regulation of fibronectin-dependent thymocyte migration  positive regulation of eosinophil migration  
Ontology : EGO-EBIcell morphogenesis  angiogenesis  podosome  leukocyte migration involved in inflammatory response  positive regulation of acute inflammatory response  metalloendopeptidase activity  serine-type endopeptidase activity  calcium ion binding  protein binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  proteolysis  inflammatory response  metallopeptidase activity  zinc ion binding  cell surface  positive regulation of protein processing  regulation of cell-cell adhesion  extracellular matrix disassembly  phagolysosome  dense core granule membrane  positive regulation of T cell differentiation in thymus  specific granule membrane  specific granule  neutrophil degranulation  positive regulation of MAP kinase activity  negative regulation of neuron apoptotic process  protein self-association  positive regulation of innate immune response  positive regulation of bone resorption  positive regulation of cell adhesion  lymphocyte chemotaxis  positive regulation of protein secretion  cell adhesion molecule binding  positive regulation of membrane protein ectodomain proteolysis  positive regulation of NF-kappaB transcription factor activity  positive regulation of protein kinase B signaling  positive regulation of thymocyte apoptotic process  tertiary granule  tertiary granule membrane  alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex  alpha9-beta1 integrin-ADAM8 complex  cellular response to hypoxia  cell-cell adhesion  ficolin-1-rich granule membrane  positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  positive regulation of neutrophil extravasation  positive regulation of fibronectin-dependent thymocyte migration  positive regulation of eosinophil migration  
NDEx NetworkADAM8
Atlas of Cancer Signalling NetworkADAM8
Wikipedia pathwaysADAM8
Orthology - Evolution
OrthoDB101
GeneTree (enSembl)ENSG00000151651
Phylogenetic Trees/Animal Genes : TreeFamADAM8
HOGENOMP78325
Homologs : HomoloGeneADAM8
Homology/Alignments : Family Browser (UCSC)ADAM8
Gene fusions - Rearrangements
Fusion : QuiverADAM8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAM8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAM8
dbVarADAM8
ClinVarADAM8
1000_GenomesADAM8 
Exome Variant ServerADAM8
ExAC (Exome Aggregation Consortium)ENSG00000151651
GNOMAD BrowserENSG00000151651
Varsome BrowserADAM8
Genetic variants : HAPMAP101
Genomic Variants (DGV)ADAM8 [DGVbeta]
DECIPHERADAM8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAM8 
Mutations
ICGC Data PortalADAM8 
TCGA Data PortalADAM8 
Broad Tumor PortalADAM8
OASIS PortalADAM8 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDADAM8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAM8
DgiDB (Drug Gene Interaction Database)ADAM8
DoCM (Curated mutations)ADAM8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAM8 (select a term)
intoGenADAM8
Cancer3DADAM8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602267   
Orphanet
DisGeNETADAM8
MedgenADAM8
Genetic Testing Registry ADAM8
NextProtP78325 [Medical]
TSGene101
GENETestsADAM8
Target ValidationADAM8
Huge Navigator ADAM8 [HugePedia]
snp3D : Map Gene to Disease101
BioCentury BCIQADAM8
ClinGenADAM8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD101
Chemical/Pharm GKB GenePA24533
Clinical trialADAM8
Miscellaneous
canSAR (ICR)ADAM8 (select the gene name)
DataMed IndexADAM8
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAM8
EVEXADAM8
GoPubMedADAM8
iHOPADAM8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu May 2 12:38:16 CEST 2019
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