ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1)

Identity

Other names	C3-C5
	KIAA1346
	METH1
HGNC	ADAMTS1
Location	21q21.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ADAMTS1   217
Entrez_Gene	ADAMTS1  9510  ADAM metallopeptidase with thrombospondin type 1 motif, 1
	Cards
GeneCards	ADAMTS1
Ensembl	ADAMTS1 [Search_View]   ENSG00000154734 [Gene_View]
Genatlas	ADAMTS1
GeneLynx	ADAMTS1
eGenome	ADAMTS1
euGene	9510
	Genomic and cartography
GoldenPath	ADAMTS1  -  21q21.3   chr21:27130477-27139599 -  21q21.3   [Description]    (hg18-March_2006)
Ensembl	ADAMTS1 - 21q21.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ADAMTS1
	Gene and transcription
Genbank	AB037767 [ ENTREZ ]
Genbank	AF060152 [ ENTREZ ]
Genbank	AF170084 [ ENTREZ ]
Genbank	AF207664 [ ENTREZ ]
Genbank	AK023795 [ ENTREZ ]
RefSeq	NM_006988 [ SRS ]    NM_006988 [ ENTREZ ]
RefSeq	AC_000064 [ SRS ]    AC_000064 [ ENTREZ ]
RefSeq	AC_000153 [ SRS ]    AC_000153 [ ENTREZ ]
RefSeq	NC_000021 [ SRS ]    NC_000021 [ ENTREZ ]
RefSeq	NT_011512 [ SRS ]    NT_011512 [ ENTREZ ]
RefSeq	NW_001838706 [ SRS ]    NW_001838706 [ ENTREZ ]
RefSeq	NW_927384 [ SRS ]    NW_927384 [ ENTREZ ]
AceView	ADAMTS1 AceView - NCBI
Unigene	Hs.643357 [ SRS ]    Hs.643357 [ NCBI ]     HS643357 [ spliceNest ]
Fast-db	1351 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q5HYL0 [ SRS]    Q5HYL0 [ EXPASY ]     Q5HYL0 [ INTERPRO ]     Q5HYL0 [ UNIPROT ]
Prosite	PS50215 ADAM_MEPRO [ SRS ]    PS50215 ADAM_MEPRO [ Expasy ]
Prosite	PS00086 CYTOCHROME_P450 [ SRS ]    PS00086 CYTOCHROME_P450 [ Expasy ]
Prosite	PS50092 TSP1 [ SRS ]    PS50092 TSP1 [ Expasy ]
Prosite	PS00142 ZINC_PROTEASE [ SRS ]    PS00142 ZINC_PROTEASE [ Expasy ]
Interpro	IPR006586 ADAM_cysteine [ SRS ]    IPR006586 ADAM_cysteine [ EBI ]
Interpro	IPR010294 ADAM_spacer1 [ SRS ]    IPR010294 ADAM_spacer1 [ EBI ]
Interpro	IPR001128 Cyt_P450 [ SRS ]    IPR001128 Cyt_P450 [ EBI ]
Interpro	IPR013274 Pept_M12B_ADAM-TS1 [ SRS ]    IPR013274 Pept_M12B_ADAM-TS1 [ EBI ]
Interpro	IPR006025 Pept_M_Zn_BS [ SRS ]    IPR006025 Pept_M_Zn_BS [ EBI ]
Interpro	IPR001590 Peptidase_M12B [ SRS ]    IPR001590 Peptidase_M12B [ EBI ]
Interpro	IPR013273 Peptidase_M12B_ADAM-TS [ SRS ]    IPR013273 Peptidase_M12B_ADAM-TS [ EBI ]
Interpro	IPR002870 Peptidase_M12B_N [ SRS ]    IPR002870 Peptidase_M12B_N [ EBI ]
Interpro	IPR000884 TSP1 [ SRS ]    IPR000884 TSP1 [ EBI ]
Interpro	IPR008085 TSP_1 [ SRS ]    IPR008085 TSP_1 [ EBI ]
CluSTr	Q5HYL0
Pfam	PF05986 ADAM_spacer1 [ SRS ]    PF05986 ADAM_spacer1 [ Sanger ]    pfam05986 [ NCBI-CDD ]
Pfam	PF01562 Pep_M12B_propep [ SRS ]    PF01562 Pep_M12B_propep [ Sanger ]    pfam01562 [ NCBI-CDD ]
Pfam	PF01421 Reprolysin [ SRS ]    PF01421 Reprolysin [ Sanger ]    pfam01421 [ NCBI-CDD ]
Pfam	PF00090 TSP_1 [ SRS ]    PF00090 TSP_1 [ Sanger ]    pfam00090 [ NCBI-CDD ]
Smart	SM00608 ACR [EMBL]
Smart	SM00209 TSP1 [EMBL]
Blocks	Q5HYL0
HPRD	05530
	Protein Interaction databases
DIP	Q5HYL0
IntAct	Q5HYL0
	Polymorphism : SNP, mutations, diseases
OMIM	605174    [ map ]
GENECLINICS	605174
SNP	ADAMTS1 [dbSNP-NCBI]
SNP	NM_006988 [SNP-NCI]
SNP	ADAMTS1 [GeneSNPs - Utah]  ADAMTS1] [HGBASE - SRS]
HAPMAP	ADAMTS1 [HAPMAP]
COSMIC	ADAMTS1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ADAMTS1
	General knowledge
Family Browser	ADAMTS1 [UCSC Family Browser]
SOURCE	NM_006988
SMD	Hs.643357
SAGE	Hs.643357
GO	metalloendopeptidase activity [Amigo]  metalloendopeptidase activity
GO	extracellular region [Amigo]  extracellular region
GO	proteinaceous extracellular matrix [Amigo]  proteinaceous extracellular matrix
GO	proteolysis [Amigo]  proteolysis
GO	integrin-mediated signaling pathway [Amigo]  integrin-mediated signaling pathway
GO	heparin binding [Amigo]  heparin binding
GO	zinc ion binding [Amigo]  zinc ion binding
GO	negative regulation of cell proliferation [Amigo]  negative regulation of cell proliferation
GO	metal ion binding [Amigo]  metal ion binding
PubGene	ADAMTS1
TreeFam	ADAMTS1
CTD	9510 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ADAMTS1 Related clones (RZPD - Berlin)
	PubMed
PubMed	36 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Sep 29 17:45:47 2008