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ADAMTS10 (ADAM metallopeptidase with thrombospondin type 1 motif 10)

Identity

Alias_namesa disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif
Alias_symbol (synonym)ADAM-TS10
Other aliasADAMTS-10
WMS
WMS1
HGNC (Hugo) ADAMTS10
LocusID (NCBI) 81794
Atlas_Id 46725
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 8580240 and ends at 8592196 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADAMTS10 (19p13.2) / ADGRG1 (16q21)ADAMTS10 (19p13.2) / MLLT1 (19p13.3)ADGRG1 (16q21) / ADAMTS10 (19p13.2)
ADAMTS10 19p13.2 / MLLT1 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAMTS10   13201
Cards
Entrez_Gene (NCBI)ADAMTS10  81794  ADAM metallopeptidase with thrombospondin type 1 motif 10
AliasesADAM-TS10; ADAMTS-10; WMS; WMS1
GeneCards (Weizmann)ADAMTS10
Ensembl hg19 (Hinxton)ENSG00000142303 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142303 [Gene_View]  chr19:8580240-8592196 [Contig_View]  ADAMTS10 [Vega]
ICGC DataPortalENSG00000142303
TCGA cBioPortalADAMTS10
AceView (NCBI)ADAMTS10
Genatlas (Paris)ADAMTS10
WikiGenes81794
SOURCE (Princeton)ADAMTS10
Genetics Home Reference (NIH)ADAMTS10
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTS10  -     chr19:8580240-8592196 -  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTS10  -     19p13.2   [Description]    (hg19-Feb_2009)
EnsemblADAMTS10 - 19p13.2 [CytoView hg19]  ADAMTS10 - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBIADAMTS10 [Mapview hg19]  ADAMTS10 [Mapview hg38]
OMIM277600   608990   
Gene and transcription
Genbank (Entrez)AB209515 AF163762 AK131414 BC029308 BC169218
RefSeq transcript (Entrez)NM_001282352 NM_030957
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAMTS10
Cluster EST : UnigeneHs.657508 [ NCBI ]
CGAP (NCI)Hs.657508
Alternative Splicing GalleryENSG00000142303
Gene ExpressionADAMTS10 [ NCBI-GEO ]   ADAMTS10 [ EBI - ARRAY_EXPRESS ]   ADAMTS10 [ SEEK ]   ADAMTS10 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81794
GTEX Portal (Tissue expression)ADAMTS10
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H324   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H324  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H324
Splice isoforms : SwissVarQ9H324
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9H324
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    PLAC (PS50900)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM_spacer1    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_ADAM-TS    Peptidase_M12B_N    PLAC    TSP1_rpt   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    PLAC (PF08686)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam01562    pfam08686    pfam01421    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS10
DMDM Disease mutations81794
Blocks (Seattle)ADAMTS10
SuperfamilyQ9H324
Human Protein AtlasENSG00000142303
Peptide AtlasQ9H324
HPRD07470
IPIIPI00215794   IPI00442054   IPI00555655   
Protein Interaction databases
DIP (DOE-UCLA)Q9H324
IntAct (EBI)Q9H324
FunCoupENSG00000142303
BioGRIDADAMTS10
STRING (EMBL)ADAMTS10
ZODIACADAMTS10
Ontologies - Pathways
QuickGOQ9H324
Ontology : AmiGOmicrofibril  molecular_function  metalloendopeptidase activity  protein binding  proteinaceous extracellular matrix  proteolysis  biological_process  zinc ion binding  extracellular matrix  
Ontology : EGO-EBImicrofibril  molecular_function  metalloendopeptidase activity  protein binding  proteinaceous extracellular matrix  proteolysis  biological_process  zinc ion binding  extracellular matrix  
NDEx NetworkADAMTS10
Atlas of Cancer Signalling NetworkADAMTS10
Wikipedia pathwaysADAMTS10
Orthology - Evolution
OrthoDB81794
GeneTree (enSembl)ENSG00000142303
Phylogenetic Trees/Animal Genes : TreeFamADAMTS10
HOVERGENQ9H324
HOGENOMQ9H324
Homologs : HomoloGeneADAMTS10
Homology/Alignments : Family Browser (UCSC)ADAMTS10
Gene fusions - Rearrangements
Fusion : MitelmanADAMTS10/MLLT1 [19p13.2/19p13.3]  
Fusion: TCGAADAMTS10 19p13.2 MLLT1 19p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS10
dbVarADAMTS10
ClinVarADAMTS10
1000_GenomesADAMTS10 
Exome Variant ServerADAMTS10
ExAC (Exome Aggregation Consortium)ADAMTS10 (select the gene name)
Genetic variants : HAPMAP81794
Genomic Variants (DGV)ADAMTS10 [DGVbeta]
DECIPHERADAMTS10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTS10 
Mutations
ICGC Data PortalADAMTS10 
TCGA Data PortalADAMTS10 
Broad Tumor PortalADAMTS10
OASIS PortalADAMTS10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAMTS10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch ADAMTS10
DgiDB (Drug Gene Interaction Database)ADAMTS10
DoCM (Curated mutations)ADAMTS10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS10 (select a term)
intoGenADAMTS10
Cancer3DADAMTS10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM277600    608990   
Orphanet3033   
MedgenADAMTS10
Genetic Testing Registry ADAMTS10
NextProtQ9H324 [Medical]
TSGene81794
GENETestsADAMTS10
Target ValidationADAMTS10
Huge Navigator ADAMTS10 [HugePedia]
snp3D : Map Gene to Disease81794
BioCentury BCIQADAMTS10
ClinGenADAMTS10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD81794
Chemical/Pharm GKB GenePA24537
Clinical trialADAMTS10
Miscellaneous
canSAR (ICR)ADAMTS10 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAMTS10
EVEXADAMTS10
GoPubMedADAMTS10
iHOPADAMTS10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 18:56:11 CEST 2017

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