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ADAMTS17 (ADAM metallopeptidase with thrombospondin type 1 motif 17)

Identity

Alias_namesa disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif
Alias_symbol (synonym)FLJ32769
FLJ16363
Other alias-
HGNC (Hugo) ADAMTS17
LocusID (NCBI) 170691
Atlas_Id 54106
Location 15q26.3  [Link to chromosome band 15q26]
Location_base_pair Starts at 99971438 and ends at 100342005 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADAMTS17 (15q26.3) / CERS3 (15q26.3)ADAMTS17 (15q26.3) / LPAR1 (9q31.3)ADAMTS17 (15q26.3) / PCDHA8 (5q31.3)
ADAMTS17 (15q26.3) / RTKN2 (10q21.2)LRRK1 (15q26.3) / ADAMTS17 (15q26.3)PARD3 (10p11.22) / ADAMTS17 (15q26.3)
ADAMTS17 15q26.3 / CERS3 15q26.3ADAMTS17 15q26.3 / PCDHA8 5q31.3ADAMTS17 15q26.3 / RTKN2 10q21.2
LRRK1 15q26.3 / ADAMTS17 15q26.3PARD3 10p11.22 / ADAMTS17 15q26.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAMTS17   17109
Cards
Entrez_Gene (NCBI)ADAMTS17  170691  ADAM metallopeptidase with thrombospondin type 1 motif 17
Aliases
GeneCards (Weizmann)ADAMTS17
Ensembl hg19 (Hinxton)ENSG00000140470 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140470 [Gene_View]  chr15:99971438-100342005 [Contig_View]  ADAMTS17 [Vega]
ICGC DataPortalENSG00000140470
TCGA cBioPortalADAMTS17
AceView (NCBI)ADAMTS17
Genatlas (Paris)ADAMTS17
WikiGenes170691
SOURCE (Princeton)ADAMTS17
Genetics Home Reference (NIH)ADAMTS17
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTS17  -     chr15:99971438-100342005 -  15q26.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTS17  -     15q26.3   [Description]    (hg19-Feb_2009)
EnsemblADAMTS17 - 15q26.3 [CytoView hg19]  ADAMTS17 - 15q26.3 [CytoView hg38]
Mapping of homologs : NCBIADAMTS17 [Mapview hg19]  ADAMTS17 [Mapview hg38]
OMIM607511   613195   
Gene and transcription
Genbank (Entrez)AA884550 AJ315735 AK057331 AK057529 AK131344
RefSeq transcript (Entrez)NM_139057
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAMTS17
Cluster EST : UnigeneHs.513200 [ NCBI ]
CGAP (NCI)Hs.513200
Alternative Splicing GalleryENSG00000140470
Gene ExpressionADAMTS17 [ NCBI-GEO ]   ADAMTS17 [ EBI - ARRAY_EXPRESS ]   ADAMTS17 [ SEEK ]   ADAMTS17 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS17 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)170691
GTEX Portal (Tissue expression)ADAMTS17
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TE56   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TE56  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TE56
Splice isoforms : SwissVarQ8TE56
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ8TE56
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    PLAC (PS50900)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM_Cys-rich    ADAM_spacer1    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_ADAM-TS    Peptidase_M12B_N    PLAC    TSP1_rpt    Znf_C2H2   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam01562    pfam01421    pfam00090   
Domain families : Smart (EMBL)ACR (SM00608)  TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS17
DMDM Disease mutations170691
Blocks (Seattle)ADAMTS17
SuperfamilyQ8TE56
Human Protein AtlasENSG00000140470
Peptide AtlasQ8TE56
HPRD06332
IPIIPI00152635   IPI00442191   
Protein Interaction databases
DIP (DOE-UCLA)Q8TE56
IntAct (EBI)Q8TE56
FunCoupENSG00000140470
BioGRIDADAMTS17
STRING (EMBL)ADAMTS17
ZODIACADAMTS17
Ontologies - Pathways
QuickGOQ8TE56
Ontology : AmiGOnucleic acid binding  metalloendopeptidase activity  proteinaceous extracellular matrix  proteolysis  zinc ion binding  
Ontology : EGO-EBInucleic acid binding  metalloendopeptidase activity  proteinaceous extracellular matrix  proteolysis  zinc ion binding  
NDEx NetworkADAMTS17
Atlas of Cancer Signalling NetworkADAMTS17
Wikipedia pathwaysADAMTS17
Orthology - Evolution
OrthoDB170691
GeneTree (enSembl)ENSG00000140470
Phylogenetic Trees/Animal Genes : TreeFamADAMTS17
HOVERGENQ8TE56
HOGENOMQ8TE56
Homologs : HomoloGeneADAMTS17
Homology/Alignments : Family Browser (UCSC)ADAMTS17
Gene fusions - Rearrangements
Fusion : MitelmanADAMTS17/CERS3 [15q26.3/15q26.3]  
Fusion : MitelmanADAMTS17/LPAR1 [15q26.3/9q31.3]  [t(9;15)(q31;q26)]  
Fusion : MitelmanADAMTS17/PCDHA8 [15q26.3/5q31.3]  [t(5;15)(q31;q26)]  
Fusion : MitelmanADAMTS17/RTKN2 [15q26.3/10q21.2]  [t(10;15)(q21;q26)]  
Fusion : MitelmanLRRK1/ADAMTS17 [15q26.3/15q26.3]  [t(15;15)(q26;q26)]  
Fusion : MitelmanPARD3/ADAMTS17 [10p11.22/15q26.3]  [t(10;15)(p11;q26)]  
Fusion: TCGAADAMTS17 15q26.3 CERS3 15q26.3 LUSC
Fusion: TCGAADAMTS17 15q26.3 PCDHA8 5q31.3 BRCA
Fusion: TCGAADAMTS17 15q26.3 RTKN2 10q21.2 PRAD
Fusion: TCGALRRK1 15q26.3 ADAMTS17 15q26.3 BRCA
Fusion: TCGAPARD3 10p11.22 ADAMTS17 15q26.3 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS17 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS17
dbVarADAMTS17
ClinVarADAMTS17
1000_GenomesADAMTS17 
Exome Variant ServerADAMTS17
ExAC (Exome Aggregation Consortium)ADAMTS17 (select the gene name)
Genetic variants : HAPMAP170691
Genomic Variants (DGV)ADAMTS17 [DGVbeta]
DECIPHERADAMTS17 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTS17 
Mutations
ICGC Data PortalADAMTS17 
TCGA Data PortalADAMTS17 
Broad Tumor PortalADAMTS17
OASIS PortalADAMTS17 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS17  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAMTS17
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAMTS17
DgiDB (Drug Gene Interaction Database)ADAMTS17
DoCM (Curated mutations)ADAMTS17 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS17 (select a term)
intoGenADAMTS17
Cancer3DADAMTS17(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607511    613195   
Orphanet22357   
MedgenADAMTS17
Genetic Testing Registry ADAMTS17
NextProtQ8TE56 [Medical]
TSGene170691
GENETestsADAMTS17
Target ValidationADAMTS17
Huge Navigator ADAMTS17 [HugePedia]
snp3D : Map Gene to Disease170691
BioCentury BCIQADAMTS17
ClinGenADAMTS17
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD170691
Chemical/Pharm GKB GenePA24543
Clinical trialADAMTS17
Miscellaneous
canSAR (ICR)ADAMTS17 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAMTS17
EVEXADAMTS17
GoPubMedADAMTS17
iHOPADAMTS17
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:54:23 CEST 2017

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