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ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif 18)

Identity

Alias_namesADAMTS21
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif
Other aliasKNO2
MMCAT
HGNC (Hugo) ADAMTS18
LocusID (NCBI) 170692
Atlas_Id 47184
Location 16q23.1  [Link to chromosome band 16q23]
Location_base_pair Starts at 77282128 and ends at 77435114 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CEP85 (1p36.11) / ADAMTS18 (16q23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAMTS18   17110
Cards
Entrez_Gene (NCBI)ADAMTS18  170692  ADAM metallopeptidase with thrombospondin type 1 motif 18
AliasesADAMTS21; KNO2; MMCAT
GeneCards (Weizmann)ADAMTS18
Ensembl hg19 (Hinxton)ENSG00000140873 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140873 [Gene_View]  chr16:77282128-77435114 [Contig_View]  ADAMTS18 [Vega]
ICGC DataPortalENSG00000140873
TCGA cBioPortalADAMTS18
AceView (NCBI)ADAMTS18
Genatlas (Paris)ADAMTS18
WikiGenes170692
SOURCE (Princeton)ADAMTS18
Genetics Home Reference (NIH)ADAMTS18
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTS18  -     chr16:77282128-77435114 -  16q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTS18  -     16q23.1   [Description]    (hg19-Feb_2009)
EnsemblADAMTS18 - 16q23.1 [CytoView hg19]  ADAMTS18 - 16q23.1 [CytoView hg38]
Mapping of homologs : NCBIADAMTS18 [Mapview hg19]  ADAMTS18 [Mapview hg38]
OMIM607512   615458   
Gene and transcription
Genbank (Entrez)AF086229 AI792764 AJ311903 AK122677 AK131403
RefSeq transcript (Entrez)NM_001326358 NM_139054 NM_199355
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAMTS18
Cluster EST : UnigeneHs.188746 [ NCBI ]
CGAP (NCI)Hs.188746
Alternative Splicing GalleryENSG00000140873
Gene ExpressionADAMTS18 [ NCBI-GEO ]   ADAMTS18 [ EBI - ARRAY_EXPRESS ]   ADAMTS18 [ SEEK ]   ADAMTS18 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)170692
GTEX Portal (Tissue expression)ADAMTS18
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TE60   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TE60  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TE60
Splice isoforms : SwissVarQ8TE60
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ8TE60
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    PLAC (PS50900)    TSP1 (PS50092)   
Domains : Interpro (EBI)ADAM_spacer1    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_ADAM-TS    Peptidase_M12B_N    PLAC    TSP1_rpt   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    PLAC (PF08686)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam01562    pfam08686    pfam01421    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS18
DMDM Disease mutations170692
Blocks (Seattle)ADAMTS18
SuperfamilyQ8TE60
Human Protein AtlasENSG00000140873
Peptide AtlasQ8TE60
HPRD06333
IPIIPI00291532   IPI00411930   IPI00910403   IPI00442076   
Protein Interaction databases
DIP (DOE-UCLA)Q8TE60
IntAct (EBI)Q8TE60
FunCoupENSG00000140873
BioGRIDADAMTS18
STRING (EMBL)ADAMTS18
ZODIACADAMTS18
Ontologies - Pathways
QuickGOQ8TE60
Ontology : AmiGOeye development  metalloendopeptidase activity  proteinaceous extracellular matrix  proteolysis  zinc ion binding  negative regulation of platelet aggregation  
Ontology : EGO-EBIeye development  metalloendopeptidase activity  proteinaceous extracellular matrix  proteolysis  zinc ion binding  negative regulation of platelet aggregation  
NDEx NetworkADAMTS18
Atlas of Cancer Signalling NetworkADAMTS18
Wikipedia pathwaysADAMTS18
Orthology - Evolution
OrthoDB170692
GeneTree (enSembl)ENSG00000140873
Phylogenetic Trees/Animal Genes : TreeFamADAMTS18
HOVERGENQ8TE60
HOGENOMQ8TE60
Homologs : HomoloGeneADAMTS18
Homology/Alignments : Family Browser (UCSC)ADAMTS18
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS18
dbVarADAMTS18
ClinVarADAMTS18
1000_GenomesADAMTS18 
Exome Variant ServerADAMTS18
ExAC (Exome Aggregation Consortium)ADAMTS18 (select the gene name)
Genetic variants : HAPMAP170692
Genomic Variants (DGV)ADAMTS18 [DGVbeta]
DECIPHERADAMTS18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTS18 
Mutations
ICGC Data PortalADAMTS18 
TCGA Data PortalADAMTS18 
Broad Tumor PortalADAMTS18
OASIS PortalADAMTS18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAMTS18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAMTS18
DgiDB (Drug Gene Interaction Database)ADAMTS18
DoCM (Curated mutations)ADAMTS18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS18 (select a term)
intoGenADAMTS18
Cancer3DADAMTS18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607512    615458   
Orphanet22455   
MedgenADAMTS18
Genetic Testing Registry ADAMTS18
NextProtQ8TE60 [Medical]
TSGene170692
GENETestsADAMTS18
Target ValidationADAMTS18
Huge Navigator ADAMTS18 [HugePedia]
snp3D : Map Gene to Disease170692
BioCentury BCIQADAMTS18
ClinGenADAMTS18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD170692
Chemical/Pharm GKB GenePA24544
Clinical trialADAMTS18
Miscellaneous
canSAR (ICR)ADAMTS18 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAMTS18
EVEXADAMTS18
GoPubMedADAMTS18
iHOPADAMTS18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 18:56:12 CEST 2017

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