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ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif, 18)

Identity

Other namesADAMTS21
KNO2
HGNC (Hugo) ADAMTS18
LocusID (NCBI) 170692
Location 16q23.1
Location_base_pair Starts at 77316025 and ends at 77469011 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ADAMTS18   17110
Entrez_Gene (NCBI)ADAMTS18  170692  ADAM metallopeptidase with thrombospondin type 1 motif, 18
Cards
GeneCards (Weizmann)ADAMTS18
Ensembl (Hinxton)ENSG00000140873 [Gene_View]  chr16:77316025-77469011 [Contig_View]  ADAMTS18 [Vega]
AceView (NCBI)ADAMTS18
Genatlas (Paris)ADAMTS18
SOURCE (Stanford)NM_139054 NM_199355
Genomic and cartography
GoldenPath (UCSC)ADAMTS18  -  16q23.1   chr16:77316025-77469011 -  16q23.1   [Description]    (hg19-Feb_2009)
EnsemblADAMTS18 - 16q23.1 [CytoView]
Mapping of homologs : NCBIADAMTS18 [Mapview]
OMIM607512   608454   
Gene and transcription
Genbank (Entrez)AF086229 AI792764 AJ311903 AK122677 AK131403
RefSeq transcript (SRS)NM_139054 NM_199355
RefSeq transcript (Entrez)NM_139054 NM_199355
RefSeq genomic (SRS)AC_000148 NC_000016 NC_018927 NG_031879 NT_010498 NW_001838328 NW_004078087
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NG_031879 NT_010498 NW_001838328 NW_004078087
Consensus coding sequences : CCDS (NCBI)ADAMTS18
Cluster EST : UnigeneHs.188746 [ SRS ] Hs.188746 [ NCBI ]
CGAP (NCI)Hs.188746
Alternative Splicing : Fast-db (Paris)GSHG0011999
Alternative Splicing GalleryENSG00000140873
Gene ExpressionADAMTS18 [ NCBI-GEO ]   ADAMTS18 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TE60 (SRS) Q8TE60 (Uniprot)
NextProtQ8TE60
With graphics : InterProQ8TE60
Splice isoforms : SwissVarQ8TE60(Swissvar)
Domaine pattern : Prosite (SRS)ADAM_MEPRO (PS50215)    CYSTEINE_SWITCH (PS00546)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)    PLAC (PS50900)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    CYSTEINE_SWITCH (PS00546)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)    PLAC (PS50900)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (SRS)ADAM_spacer1    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_ADAM-TS    Peptidase_M12B_N    PLAC    Thrombospondin_1_rpt   
Domains : Interpro (EBI)ADAM_spacer1    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_ADAM-TS    Peptidase_M12B_N    PLAC    Thrombospondin_1_rpt   
Related proteins : CluSTrQ8TE60
Domain families : Pfam (SRS)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    PLAC (PF08686)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    PLAC (PF08686)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam01562    pfam08686    pfam01421    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
DMDM170692
Blocks (Seattle)Q8TE60
Human Protein AtlasENSG00000140873
HPRD06333
IPIIPI00291532   IPI00411930   IPI00910403   IPI00442076   
Protein Interaction databases
DIP (DOE-UCLA)Q8TE60
IntAct (EBI)Q8TE60
FunCoupENSG00000140873
REACTOMEADAMTS18
Protein Interaction Database170692
BioGRIDADAMTS18
InParanoidQ8TE60
Interologous Interaction database Q8TE60
IntegromeDBADAMTS18
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ADAMTS18
SNP (GeneSNP Utah)ADAMTS18
SNP : HGBaseADAMTS18
Genetic variants : HAPMAPADAMTS18
Somatic Mutations in Cancer : COSMICADAMTS18 
CONAN: Copy Number AnalysisADAMTS18 
Mutations and Diseases : HGMDADAMTS18
OMIM607512    608454   
GENETests607512    608454   
Disease Genetic AssociationADAMTS18
Huge Navigator ADAMTS18 [HugePedia]  ADAMTS18 [HugeCancerGEM]
Genomic VariantsADAMTS18  ADAMTS18 [DGVbeta]
snp3D : Map Gene to Disease170692
General knowledge
Homologs : HomoloGeneADAMTS18
Homology/Alignments : Family Browser (UCSC)ADAMTS18
Phylogenetic Trees/Animal Genes : TreeFamADAMTS18
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.- [ Enzyme-SRS ]   3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
Chemical/Protein Interactions : CTD170692
Chemical/Pharm GKB GenePA24544
Clinical trialADAMTS18
Cancer Resource (Charite)ENSG00000140873
Ontology : AmiGOmetalloendopeptidase activity  proteinaceous extracellular matrix  proteolysis  zinc ion binding  metal ion binding  
Ontology : EGO-EBImetalloendopeptidase activity  proteinaceous extracellular matrix  proteolysis  zinc ion binding  metal ion binding  
Other databases
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
PubGeneADAMTS18
iHOPADAMTS18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:26:35 CEST 2013
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