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ADAMTS19 (ADAM metallopeptidase with thrombospondin type 1 motif 19)

Identity

Alias (NCBI)-
HGNC (Hugo) ADAMTS19
HGNC Previous namea disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 19
LocusID (NCBI) 171019
Atlas_Id 54107
Location 5q23.3  [Link to chromosome band 5q23]
Location_base_pair Starts at 129460298 and ends at 129738683 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAMTS19 (5q23.3) / SLC27A6 (5q23.3)KIF2A (5q12.1) / ADAMTS19 (5q23.3)RUNX1 (21q22.12) / ADAMTS19 (5q23.3)
KIF2A 5q12.1 / ADAMTS19 5q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;21)(q23;q22) RUNX1/ADAMTS19


External links

 

Nomenclature
HGNC (Hugo)ADAMTS19   17111
Cards
Entrez_Gene (NCBI)ADAMTS19    ADAM metallopeptidase with thrombospondin type 1 motif 19
Aliases
GeneCards (Weizmann)ADAMTS19
Ensembl hg19 (Hinxton)ENSG00000145808 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145808 [Gene_View]  ENSG00000145808 [Sequence]  chr5:129460298-129738683 [Contig_View]  ADAMTS19 [Vega]
ICGC DataPortalENSG00000145808
TCGA cBioPortalADAMTS19
AceView (NCBI)ADAMTS19
Genatlas (Paris)ADAMTS19
SOURCE (Princeton)ADAMTS19
Genetics Home Reference (NIH)ADAMTS19
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTS19  -     chr5:129460298-129738683 +  5q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTS19  -     5q23.3   [Description]    (hg19-Feb_2009)
GoldenPathADAMTS19 - 5q23.3 [CytoView hg19]  ADAMTS19 - 5q23.3 [CytoView hg38]
ImmunoBaseENSG00000145808
Genome Data Viewer NCBIADAMTS19 [Mapview hg19]  
OMIM607513   
Gene and transcription
Genbank (Entrez)AI366752 AJ311904 AK122622 AK128729 AW473680
RefSeq transcript (Entrez)NM_133638
Consensus coding sequences : CCDS (NCBI)ADAMTS19
Gene ExpressionADAMTS19 [ NCBI-GEO ]   ADAMTS19 [ EBI - ARRAY_EXPRESS ]   ADAMTS19 [ SEEK ]   ADAMTS19 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS19 [ Firebrowse - Broad ]
GenevisibleExpression of ADAMTS19 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)171019
GTEX Portal (Tissue expression)ADAMTS19
Human Protein AtlasENSG00000145808-ADAMTS19 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TE59   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TE59  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TE59
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ8TE59
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    PLAC (PS50900)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM_CR_2    ADAM_Cys-rich    ADAM_spacer1    ADAMTS/ADAMTS-like    MetalloPept_cat_dom_sf    Peptidase_M12B    Peptidase_M12B_N    PLAC    TSP1_rpt    TSP1_rpt_sf   
Domain families : Pfam (Sanger)ADAM_CR_2 (PF17771)    ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam17771    pfam05986    pfam01562    pfam01421    pfam00090   
Domain families : Smart (EMBL)ACR (SM00608)  TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS19
SuperfamilyQ8TE59
AlphaFold pdb e-kbQ8TE59   
Human Protein Atlas [tissue]ENSG00000145808-ADAMTS19 [tissue]
HPRD06334
Protein Interaction databases
DIP (DOE-UCLA)Q8TE59
IntAct (EBI)Q8TE59
BioGRIDADAMTS19
STRING (EMBL)ADAMTS19
ZODIACADAMTS19
Ontologies - Pathways
QuickGOQ8TE59
Ontology : AmiGOmetalloendopeptidase activity  extracellular region  proteolysis  extracellular matrix organization  extracellular matrix  metal ion binding  
Ontology : EGO-EBImetalloendopeptidase activity  extracellular region  proteolysis  extracellular matrix organization  extracellular matrix  metal ion binding  
NDEx NetworkADAMTS19
Atlas of Cancer Signalling NetworkADAMTS19
Wikipedia pathwaysADAMTS19
Orthology - Evolution
OrthoDB171019
GeneTree (enSembl)ENSG00000145808
Phylogenetic Trees/Animal Genes : TreeFamADAMTS19
Homologs : HomoloGeneADAMTS19
Homology/Alignments : Family Browser (UCSC)ADAMTS19
Gene fusions - Rearrangements
Fusion : MitelmanADAMTS19/SLC27A6 [5q23.3/5q23.3]  
Fusion : MitelmanKIF2A/ADAMTS19 [5q12.1/5q23.3]  
Fusion : MitelmanRUNX1/ADAMTS19 [21q22.12/5q23.3]  
Fusion : QuiverADAMTS19
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS19
dbVarADAMTS19
ClinVarADAMTS19
MonarchADAMTS19
1000_GenomesADAMTS19 
Exome Variant ServerADAMTS19
GNOMAD BrowserENSG00000145808
Varsome BrowserADAMTS19
ACMGADAMTS19 variants
VarityQ8TE59
Genomic Variants (DGV)ADAMTS19 [DGVbeta]
DECIPHERADAMTS19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTS19 
Mutations
ICGC Data PortalADAMTS19 
TCGA Data PortalADAMTS19 
Broad Tumor PortalADAMTS19
OASIS PortalADAMTS19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS19  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DADAMTS19
Mutations and Diseases : HGMDADAMTS19
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaADAMTS19
DgiDB (Drug Gene Interaction Database)ADAMTS19
DoCM (Curated mutations)ADAMTS19
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS19
Cancer3DADAMTS19
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607513   
Orphanet
DisGeNETADAMTS19
MedgenADAMTS19
Genetic Testing Registry ADAMTS19
NextProtQ8TE59 [Medical]
GENETestsADAMTS19
Target ValidationADAMTS19
Huge Navigator ADAMTS19 [HugePedia]
ClinGenADAMTS19
Clinical trials, drugs, therapy
MyCancerGenomeADAMTS19
Protein Interactions : CTDADAMTS19
Pharm GKB GenePA24545
PharosQ8TE59
Clinical trialADAMTS19
Miscellaneous
canSAR (ICR)ADAMTS19
HarmonizomeADAMTS19
DataMed IndexADAMTS19
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXADAMTS19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 14:58:28 CEST 2021

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