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ADAMTS19 (ADAM metallopeptidase with thrombospondin type 1 motif 19)

Identity

Alias_namesa disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif
Other alias-
HGNC (Hugo) ADAMTS19
LocusID (NCBI) 171019
Atlas_Id 54107
Location 5q23.3  [Link to chromosome band 5q23]
Location_base_pair Starts at 129460265 and ends at 129738683 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADAMTS19 (5q23.3) / SLC27A6 (5q23.3)KIF2A (5q12.1) / ADAMTS19 (5q23.3)RUNX1 (21q22.12) / ADAMTS19 (5q23.3)
KIF2A 5q12.1 / ADAMTS19 5q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAMTS19   17111
Cards
Entrez_Gene (NCBI)ADAMTS19  171019  ADAM metallopeptidase with thrombospondin type 1 motif 19
Aliases
GeneCards (Weizmann)ADAMTS19
Ensembl hg19 (Hinxton)ENSG00000145808 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145808 [Gene_View]  chr5:129460265-129738683 [Contig_View]  ADAMTS19 [Vega]
ICGC DataPortalENSG00000145808
TCGA cBioPortalADAMTS19
AceView (NCBI)ADAMTS19
Genatlas (Paris)ADAMTS19
WikiGenes171019
SOURCE (Princeton)ADAMTS19
Genetics Home Reference (NIH)ADAMTS19
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTS19  -     chr5:129460265-129738683 +  5q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTS19  -     5q23.3   [Description]    (hg19-Feb_2009)
EnsemblADAMTS19 - 5q23.3 [CytoView hg19]  ADAMTS19 - 5q23.3 [CytoView hg38]
Mapping of homologs : NCBIADAMTS19 [Mapview hg19]  ADAMTS19 [Mapview hg38]
OMIM607513   
Gene and transcription
Genbank (Entrez)AI366752 AJ311904 AK122622 AK128729 AW473680
RefSeq transcript (Entrez)NM_133638
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAMTS19
Cluster EST : UnigeneHs.23751 [ NCBI ]
CGAP (NCI)Hs.23751
Alternative Splicing GalleryENSG00000145808
Gene ExpressionADAMTS19 [ NCBI-GEO ]   ADAMTS19 [ EBI - ARRAY_EXPRESS ]   ADAMTS19 [ SEEK ]   ADAMTS19 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS19 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)171019
GTEX Portal (Tissue expression)ADAMTS19
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TE59   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TE59  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TE59
Splice isoforms : SwissVarQ8TE59
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ8TE59
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    PLAC (PS50900)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM_Cys-rich    ADAM_spacer1    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_ADAM-TS    Peptidase_M12B_N    PLAC    TSP1_rpt   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    PLAC (PF08686)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam01562    pfam08686    pfam01421    pfam00090   
Domain families : Smart (EMBL)ACR (SM00608)  TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS19
DMDM Disease mutations171019
Blocks (Seattle)ADAMTS19
SuperfamilyQ8TE59
Human Protein AtlasENSG00000145808
Peptide AtlasQ8TE59
HPRD06334
IPIIPI00152639   IPI00965779   IPI00966569   
Protein Interaction databases
DIP (DOE-UCLA)Q8TE59
IntAct (EBI)Q8TE59
FunCoupENSG00000145808
BioGRIDADAMTS19
STRING (EMBL)ADAMTS19
ZODIACADAMTS19
Ontologies - Pathways
QuickGOQ8TE59
Ontology : AmiGOmetalloendopeptidase activity  proteinaceous extracellular matrix  proteolysis  zinc ion binding  
Ontology : EGO-EBImetalloendopeptidase activity  proteinaceous extracellular matrix  proteolysis  zinc ion binding  
NDEx NetworkADAMTS19
Atlas of Cancer Signalling NetworkADAMTS19
Wikipedia pathwaysADAMTS19
Orthology - Evolution
OrthoDB171019
GeneTree (enSembl)ENSG00000145808
Phylogenetic Trees/Animal Genes : TreeFamADAMTS19
HOVERGENQ8TE59
HOGENOMQ8TE59
Homologs : HomoloGeneADAMTS19
Homology/Alignments : Family Browser (UCSC)ADAMTS19
Gene fusions - Rearrangements
Fusion : MitelmanADAMTS19/SLC27A6 [5q23.3/5q23.3]  
Fusion : MitelmanKIF2A/ADAMTS19 [5q12.1/5q23.3]  [t(5;5)(q12;q23)]  
Fusion : MitelmanRUNX1/ADAMTS19 [21q22.12/5q23.3]  [t(5;21)(q23;q22)]  
Fusion: TCGAKIF2A 5q12.1 ADAMTS19 5q23.3 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS19
dbVarADAMTS19
ClinVarADAMTS19
1000_GenomesADAMTS19 
Exome Variant ServerADAMTS19
ExAC (Exome Aggregation Consortium)ADAMTS19 (select the gene name)
Genetic variants : HAPMAP171019
Genomic Variants (DGV)ADAMTS19 [DGVbeta]
DECIPHERADAMTS19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTS19 
Mutations
ICGC Data PortalADAMTS19 
TCGA Data PortalADAMTS19 
Broad Tumor PortalADAMTS19
OASIS PortalADAMTS19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS19  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAMTS19
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAMTS19
DgiDB (Drug Gene Interaction Database)ADAMTS19
DoCM (Curated mutations)ADAMTS19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS19 (select a term)
intoGenADAMTS19
Cancer3DADAMTS19(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607513   
Orphanet
MedgenADAMTS19
Genetic Testing Registry ADAMTS19
NextProtQ8TE59 [Medical]
TSGene171019
GENETestsADAMTS19
Huge Navigator ADAMTS19 [HugePedia]
snp3D : Map Gene to Disease171019
BioCentury BCIQADAMTS19
ClinGenADAMTS19
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD171019
Chemical/Pharm GKB GenePA24545
Clinical trialADAMTS19
Miscellaneous
canSAR (ICR)ADAMTS19 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAMTS19
EVEXADAMTS19
GoPubMedADAMTS19
iHOPADAMTS19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:05:01 CEST 2017

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