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ADAMTS20 (ADAM metallopeptidase with thrombospondin type 1 motif 20)

Identity

Alias_namesa disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif
Alias_symbol (synonym)GON-1
Other aliasADAM-TS20
ADAMTS-20
HGNC (Hugo) ADAMTS20
LocusID (NCBI) 80070
Atlas_Id 46674
Location 12q12  [Link to chromosome band 12q12]
Location_base_pair Starts at 43353866 and ends at 43551971 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAMTS20 (12q12) / CBFA2T2 (20q11.21)HOXC4 (12q13.13) / ADAMTS20 (12q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAMTS20   17178
Cards
Entrez_Gene (NCBI)ADAMTS20  80070  ADAM metallopeptidase with thrombospondin type 1 motif 20
AliasesADAM-TS20; ADAMTS-20; GON-1
GeneCards (Weizmann)ADAMTS20
Ensembl hg19 (Hinxton)ENSG00000173157 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173157 [Gene_View]  chr12:43353866-43551971 [Contig_View]  ADAMTS20 [Vega]
ICGC DataPortalENSG00000173157
TCGA cBioPortalADAMTS20
AceView (NCBI)ADAMTS20
Genatlas (Paris)ADAMTS20
WikiGenes80070
SOURCE (Princeton)ADAMTS20
Genetics Home Reference (NIH)ADAMTS20
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTS20  -     chr12:43353866-43551971 -  12q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTS20  -     12q12   [Description]    (hg19-Feb_2009)
EnsemblADAMTS20 - 12q12 [CytoView hg19]  ADAMTS20 - 12q12 [CytoView hg38]
Mapping of homologs : NCBIADAMTS20 [Mapview hg19]  ADAMTS20 [Mapview hg38]
OMIM611681   
Gene and transcription
Genbank (Entrez)AF488804 AJ515153 AJ515154 AK023228 CN292892
RefSeq transcript (Entrez)NM_025003 NM_175851
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAMTS20
Cluster EST : UnigeneHs.287554 [ NCBI ]
CGAP (NCI)Hs.287554
Alternative Splicing GalleryENSG00000173157
Gene ExpressionADAMTS20 [ NCBI-GEO ]   ADAMTS20 [ EBI - ARRAY_EXPRESS ]   ADAMTS20 [ SEEK ]   ADAMTS20 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS20 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80070
GTEX Portal (Tissue expression)ADAMTS20
Human Protein AtlasENSG00000173157-ADAMTS20 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP59510   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP59510  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP59510
Splice isoforms : SwissVarP59510
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusP59510
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    GON (PS51046)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM_spacer1    MetalloPept_cat_dom    Pept_M12B_GON-ADAMTSs    Peptidase_M12B    Peptidase_M12B_ADAM-TS    Peptidase_M12B_N    TSP1_rpt   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    GON (PF08685)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam08685    pfam01562    pfam01421    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS20
DMDM Disease mutations80070
Blocks (Seattle)ADAMTS20
SuperfamilyP59510
Human Protein Atlas [tissue]ENSG00000173157-ADAMTS20 [tissue]
Peptide AtlasP59510
IPIIPI00414321   IPI00744130   IPI01021792   IPI01022269   IPI00874153   
Protein Interaction databases
DIP (DOE-UCLA)P59510
IntAct (EBI)P59510
FunCoupENSG00000173157
BioGRIDADAMTS20
STRING (EMBL)ADAMTS20
ZODIACADAMTS20
Ontologies - Pathways
QuickGOP59510
Ontology : AmiGOmetalloendopeptidase activity  proteinaceous extracellular matrix  extracellular space  proteolysis  zinc ion binding  positive regulation of signal transduction  extracellular matrix organization  extracellular matrix  negative regulation of apoptotic process  positive regulation of melanocyte differentiation  
Ontology : EGO-EBImetalloendopeptidase activity  proteinaceous extracellular matrix  extracellular space  proteolysis  zinc ion binding  positive regulation of signal transduction  extracellular matrix organization  extracellular matrix  negative regulation of apoptotic process  positive regulation of melanocyte differentiation  
NDEx NetworkADAMTS20
Atlas of Cancer Signalling NetworkADAMTS20
Wikipedia pathwaysADAMTS20
Orthology - Evolution
OrthoDB80070
GeneTree (enSembl)ENSG00000173157
Phylogenetic Trees/Animal Genes : TreeFamADAMTS20
HOVERGENP59510
HOGENOMP59510
Homologs : HomoloGeneADAMTS20
Homology/Alignments : Family Browser (UCSC)ADAMTS20
Gene fusions - Rearrangements
Fusion : MitelmanADAMTS20/CBFA2T2 [12q12/20q11.21]  
Fusion : MitelmanHOXC4/ADAMTS20 [12q13.13/12q12]  [t(12;12)(q12;q13)]  
Fusion: Tumor Portal ADAMTS20
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS20 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS20
dbVarADAMTS20
ClinVarADAMTS20
1000_GenomesADAMTS20 
Exome Variant ServerADAMTS20
ExAC (Exome Aggregation Consortium)ENSG00000173157
GNOMAD BrowserENSG00000173157
Genetic variants : HAPMAP80070
Genomic Variants (DGV)ADAMTS20 [DGVbeta]
DECIPHERADAMTS20 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTS20 
Mutations
ICGC Data PortalADAMTS20 
TCGA Data PortalADAMTS20 
Broad Tumor PortalADAMTS20
OASIS PortalADAMTS20 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS20  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAMTS20
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAMTS20
DgiDB (Drug Gene Interaction Database)ADAMTS20
DoCM (Curated mutations)ADAMTS20 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS20 (select a term)
intoGenADAMTS20
Cancer3DADAMTS20(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611681   
Orphanet
MedgenADAMTS20
Genetic Testing Registry ADAMTS20
NextProtP59510 [Medical]
TSGene80070
GENETestsADAMTS20
Target ValidationADAMTS20
Huge Navigator ADAMTS20 [HugePedia]
snp3D : Map Gene to Disease80070
BioCentury BCIQADAMTS20
ClinGenADAMTS20
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80070
Chemical/Pharm GKB GenePA134901626
Clinical trialADAMTS20
Miscellaneous
canSAR (ICR)ADAMTS20 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAMTS20
EVEXADAMTS20
GoPubMedADAMTS20
iHOPADAMTS20
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:39:15 CET 2017

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