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ADAMTS3 (ADAM metallopeptidase with thrombospondin type 1 motif, 3)

Identity

Other namesADAMTS-4
HGNC (Hugo) ADAMTS3
LocusID (NCBI) 9508
Location 4q13.3
Location_base_pair Starts at 73146686 and ends at 73434516 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ADAMTS3   219
Entrez_Gene (NCBI)ADAMTS3  9508  ADAM metallopeptidase with thrombospondin type 1 motif, 3
Cards
GeneCards (Weizmann)ADAMTS3
Ensembl (Hinxton)ENSG00000156140 [Gene_View]  chr4:73146686-73434516 [Contig_View]  ADAMTS3 [Vega]
AceView (NCBI)ADAMTS3
Genatlas (Paris)ADAMTS3
SOURCE (Stanford)NM_014243
Genomic and cartography
GoldenPath (UCSC)ADAMTS3  -  4q13.3   chr4:73146686-73434516 -  4q13.3   [Description]    (hg19-Feb_2009)
EnsemblADAMTS3 - 4q13.3 [CytoView]
Mapping of homologs : NCBIADAMTS3 [Mapview]
OMIM605011   
Gene and transcription
Genbank (Entrez)AB002364 AF247668 AK295131 BC016451 BC019707
RefSeq transcript (SRS)NM_014243
RefSeq transcript (Entrez)NM_014243
RefSeq genomic (SRS)AC_000136 NC_000004 NC_018915 NT_022778 NW_001838914 NW_004078021
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NT_022778 NW_001838914 NW_004078021
Consensus coding sequences : CCDS (NCBI)ADAMTS3
Cluster EST : UnigeneHs.590919 [ SRS ] Hs.590919 [ NCBI ]
CGAP (NCI)Hs.590919
Alternative Splicing : Fast-db (Paris)GSHG0023310
Alternative Splicing GalleryENSG00000156140
Gene ExpressionADAMTS3 [ NCBI-GEO ]   ADAMTS3 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15072 (SRS) O15072 (Uniprot)
NextProtO15072
With graphics : InterProO15072
Splice isoforms : SwissVarO15072(Swissvar)
Domaine pattern : Prosite (SRS)ADAM_MEPRO (PS50215)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)    PLAC (PS50900)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    DISINTEGRIN_1 (PS00427)    DISINTEGRIN_2 (PS50214)    PLAC (PS50900)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (SRS)ADAM_spacer1    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_ADAM-TS    Peptidase_M12B_N    PLAC    Thrombospondin_1_rpt   
Domains : Interpro (EBI)ADAM_spacer1    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_ADAM-TS    Peptidase_M12B_N    PLAC    Thrombospondin_1_rpt   
Related proteins : CluSTrO15072
Domain families : Pfam (SRS)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam01562    pfam01421    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
DMDM9508
Blocks (Seattle)O15072
Human Protein AtlasENSG00000156140
HPRD06893
IPIIPI00307729   
Protein Interaction databases
DIP (DOE-UCLA)O15072
IntAct (EBI)O15072
FunCoupENSG00000156140
REACTOMEADAMTS3
Protein Interaction Database9508
BioGRIDADAMTS3
InParanoidO15072
Interologous Interaction database O15072
IntegromeDBADAMTS3
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ADAMTS3
SNP (GeneSNP Utah)ADAMTS3
SNP : HGBaseADAMTS3
Genetic variants : HAPMAPADAMTS3
Somatic Mutations in Cancer : COSMICADAMTS3 
CONAN: Copy Number AnalysisADAMTS3 
Mutations and Diseases : HGMDADAMTS3
OMIM605011   
GENETests605011   
Disease Genetic AssociationADAMTS3
Huge Navigator ADAMTS3 [HugePedia]  ADAMTS3 [HugeCancerGEM]
Genomic VariantsADAMTS3  ADAMTS3 [DGVbeta]
ClinVarADAMTS3
snp3D : Map Gene to Disease9508
General knowledge
Homologs : HomoloGeneADAMTS3
Homology/Alignments : Family Browser (UCSC)ADAMTS3
Phylogenetic Trees/Animal Genes : TreeFamADAMTS3
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.- [ Enzyme-SRS ]   3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
Chemical/Protein Interactions : CTD9508
Chemical/Pharm GKB GenePA24547
Clinical trialADAMTS3
Cancer Resource (Charite)ENSG00000156140
Ontology : AmiGOmetalloendopeptidase activity  extracellular region  proteinaceous extracellular matrix  proteolysis  heparin binding  zinc ion binding  protein processing  extracellular matrix organization  collagen fibril organization  collagen catabolic process  extracellular matrix  
Ontology : EGO-EBImetalloendopeptidase activity  extracellular region  proteinaceous extracellular matrix  proteolysis  heparin binding  zinc ion binding  protein processing  extracellular matrix organization  collagen fibril organization  collagen catabolic process  extracellular matrix  
Other databases
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
PubGeneADAMTS3
iHOPADAMTS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:54:34 CEST 2013
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