ADAMTS3 (ADAM metallopeptidase with thrombospondin type 1 motif, 3)

Identity

Other names	ADAMTS-4
	KIAA0366
HGNC	ADAMTS3
Location	4q13.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ADAMTS3   219
Entrez_Gene	ADAMTS3  9508  ADAM metallopeptidase with thrombospondin type 1 motif, 3
	Cards
GeneCards	ADAMTS3
Ensembl	ADAMTS3 [Search_View]   ENSG00000156140 [Gene_View]
Genatlas	ADAMTS3
GeneLynx	ADAMTS3
eGenome	ADAMTS3
euGene	9508
	Genomic and cartography
GoldenPath	ADAMTS3  -  4q13.3   chr4:73365551-73653380 -  4q13.3   [Description]    (hg18-March_2006)
Ensembl	ADAMTS3 - 4q13.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ADAMTS3
	Gene and transcription
Genbank	AB002364 [ ENTREZ ]
Genbank	AF247668 [ ENTREZ ]
Genbank	BC016451 [ ENTREZ ]
Genbank	BC019707 [ ENTREZ ]
Genbank	BC130287 [ ENTREZ ]
RefSeq	NM_014243 [ SRS ]    NM_014243 [ ENTREZ ]
RefSeq	AC_000047 [ SRS ]    AC_000047 [ ENTREZ ]
RefSeq	AC_000136 [ SRS ]    AC_000136 [ ENTREZ ]
RefSeq	NC_000004 [ SRS ]    NC_000004 [ ENTREZ ]
RefSeq	NT_006216 [ SRS ]    NT_006216 [ ENTREZ ]
RefSeq	NW_001838914 [ SRS ]    NW_001838914 [ ENTREZ ]
RefSeq	NW_922162 [ SRS ]    NW_922162 [ ENTREZ ]
AceView	ADAMTS3 AceView - NCBI
Unigene	Hs.590919 [ SRS ]    Hs.590919 [ NCBI ]     HS590919 [ spliceNest ]
Fast-db	5387 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O15072 [ SRS]    O15072 [ EXPASY ]     O15072 [ INTERPRO ]     O15072 [ UNIPROT ]
Prosite	PS50215 ADAM_MEPRO [ SRS ]    PS50215 ADAM_MEPRO [ Expasy ]
Prosite	PS00427 DISINTEGRIN_1 [ SRS ]    PS00427 DISINTEGRIN_1 [ Expasy ]
Prosite	PS50214 DISINTEGRIN_2 [ SRS ]    PS50214 DISINTEGRIN_2 [ Expasy ]
Prosite	PS50900 PLAC [ SRS ]    PS50900 PLAC [ Expasy ]
Prosite	PS50092 TSP1 [ SRS ]    PS50092 TSP1 [ Expasy ]
Prosite	PS00142 ZINC_PROTEASE [ SRS ]    PS00142 ZINC_PROTEASE [ Expasy ]
Interpro	IPR010294 ADAM_spacer1 [ SRS ]    IPR010294 ADAM_spacer1 [ EBI ]
Interpro	IPR001762 Blood-coag_inhib_Disintegrin [ SRS ]    IPR001762 Blood-coag_inhib_Disintegrin [ EBI ]
Interpro	IPR006025 Pept_M_Zn_BS [ SRS ]    IPR006025 Pept_M_Zn_BS [ EBI ]
Interpro	IPR001590 Peptidase_M12B [ SRS ]    IPR001590 Peptidase_M12B [ EBI ]
Interpro	IPR013273 Peptidase_M12B_ADAM-TS [ SRS ]    IPR013273 Peptidase_M12B_ADAM-TS [ EBI ]
Interpro	IPR002870 Peptidase_M12B_N [ SRS ]    IPR002870 Peptidase_M12B_N [ EBI ]
Interpro	IPR010909 PLAC [ SRS ]    IPR010909 PLAC [ EBI ]
Interpro	IPR000884 TSP1 [ SRS ]    IPR000884 TSP1 [ EBI ]
Interpro	IPR008085 TSP_1 [ SRS ]    IPR008085 TSP_1 [ EBI ]
CluSTr	O15072
Pfam	PF05986 ADAM_spacer1 [ SRS ]    PF05986 ADAM_spacer1 [ Sanger ]    pfam05986 [ NCBI-CDD ]
Pfam	PF01562 Pep_M12B_propep [ SRS ]    PF01562 Pep_M12B_propep [ Sanger ]    pfam01562 [ NCBI-CDD ]
Pfam	PF01421 Reprolysin [ SRS ]    PF01421 Reprolysin [ Sanger ]    pfam01421 [ NCBI-CDD ]
Pfam	PF00090 TSP_1 [ SRS ]    PF00090 TSP_1 [ Sanger ]    pfam00090 [ NCBI-CDD ]
Smart	SM00209 TSP1 [EMBL]
Blocks	O15072
HPRD	06893
	Protein Interaction databases
DIP	O15072
IntAct	O15072
	Polymorphism : SNP, mutations, diseases
OMIM	605011    [ map ]
GENECLINICS	605011
SNP	ADAMTS3 [dbSNP-NCBI]
SNP	NM_014243 [SNP-NCI]
SNP	ADAMTS3 [GeneSNPs - Utah]  ADAMTS3] [HGBASE - SRS]
HAPMAP	ADAMTS3 [HAPMAP]
COSMIC	ADAMTS3 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ADAMTS3
	General knowledge
Family Browser	ADAMTS3 [UCSC Family Browser]
SOURCE	NM_014243
SMD	Hs.590919
SAGE	Hs.590919
Enzyme	3.4.24.- [ Enzyme-Expasy ]   3.4.24.- [ Enzyme-SRS ]   3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   3.4.24.- [ WIT ]
GO	extracellular region [Amigo]  extracellular region
GO	proteinaceous extracellular matrix [Amigo]  proteinaceous extracellular matrix
GO	heparin binding [Amigo]  heparin binding
GO	zinc ion binding [Amigo]  zinc ion binding
GO	procollagen N-endopeptidase activity [Amigo]  procollagen N-endopeptidase activity
GO	collagen fibril organization [Amigo]  collagen fibril organization
GO	collagen catabolic process [Amigo]  collagen catabolic process
GO	metal ion binding [Amigo]  metal ion binding
GO	protein maturation via proteolysis [Amigo]  protein maturation via proteolysis
PubGene	ADAMTS3
TreeFam	ADAMTS3
CTD	9508 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ADAMTS3 Related clones (RZPD - Berlin)
	PubMed
PubMed	10 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 19:59:02 2008