Identity
HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
ADAMTS-2,ADAMTS-4,ADMP-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9507
MIM: 603876
HGNC: 220
Ensembl: ENSG00000158859
Variants:
dbSNP: 9507
ClinVar: 9507
TCGA: ENSG00000158859
COSMIC: ADAMTS4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000158859 | ENST00000367995 | Q5VTW1 |
| ENSG00000158859 | ENST00000367996 | O75173 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38461223 | 2024 | ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition. | 1 |
| 38867123 | 2024 | Amino-terminally elongated Aβ peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brains. | 0 |
| 38990242 | 2024 | miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4. | 0 |
| 38461223 | 2024 | ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition. | 1 |
| 38867123 | 2024 | Amino-terminally elongated Aβ peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brains. | 0 |
| 38990242 | 2024 | miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4. | 0 |
| 36721026 | 2023 | ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711. | 2 |
| 37216221 | 2023 | Oxidized LDL-mediated upregulation of ADAMTS-4 in monocytes/macrophages involves ROS-NF-κB-SIRT-1 pathway. | 0 |
| 36721026 | 2023 | ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711. | 2 |
| 37216221 | 2023 | Oxidized LDL-mediated upregulation of ADAMTS-4 in monocytes/macrophages involves ROS-NF-κB-SIRT-1 pathway. | 0 |
| 34718343 | 2022 | Synergistic upregulation of ADAMTS4 (aggrecanase-1) by cytokines and its suppression in knee osteoarthritic synovial fibroblasts. | 7 |
| 35051931 | 2022 | The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities. | 9 |
| 35701493 | 2022 | Identification of Adamts4 as a novel adult cardiac injury biomarker with therapeutic implications in patients with cardiac injuries. | 2 |
| 34718343 | 2022 | Synergistic upregulation of ADAMTS4 (aggrecanase-1) by cytokines and its suppression in knee osteoarthritic synovial fibroblasts. | 7 |
| 35051931 | 2022 | The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities. | 9 |
Citation
Dessen P
ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif 4)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47337/adamts4
