ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif, 5)

Identity

Other names	ADAMTS11
	ADMP-2
	FLJ36738
HGNC	ADAMTS5
Location	21q21.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ADAMTS5   221
Entrez_Gene	ADAMTS5  11096  ADAM metallopeptidase with thrombospondin type 1 motif, 5
	Cards
GeneCards	ADAMTS5
Ensembl	ADAMTS5 [Search_View]   ENSG00000154736 [Gene_View]
Genatlas	ADAMTS5
GeneLynx	ADAMTS5
eGenome	ADAMTS5
euGene	11096
	Genomic and cartography
GoldenPath	ADAMTS5  -  21q21.3   chr21:27212103-27261310 -  21q21.3   [Description]    (hg18-March_2006)
Ensembl	ADAMTS5 - 21q21.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ADAMTS5
	Gene and transcription
Genbank	AF086299 [ ENTREZ ]
Genbank	AF086358 [ ENTREZ ]
Genbank	AF141293 [ ENTREZ ]
Genbank	AF142099 [ ENTREZ ]
Genbank	AK094057 [ ENTREZ ]
RefSeq	NM_007038 [ SRS ]    NM_007038 [ ENTREZ ]
RefSeq	AC_000064 [ SRS ]    AC_000064 [ ENTREZ ]
RefSeq	AC_000153 [ SRS ]    AC_000153 [ ENTREZ ]
RefSeq	NC_000021 [ SRS ]    NC_000021 [ ENTREZ ]
RefSeq	NT_011512 [ SRS ]    NT_011512 [ ENTREZ ]
RefSeq	NW_001838706 [ SRS ]    NW_001838706 [ ENTREZ ]
RefSeq	NW_927384 [ SRS ]    NW_927384 [ ENTREZ ]
AceView	ADAMTS5 AceView - NCBI
Unigene	Hs.58324 [ SRS ]    Hs.58324 [ NCBI ]     HS58324 [ spliceNest ]
Fast-db	1357 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q9UNA0 [ SRS]    Q9UNA0 [ EXPASY ]     Q9UNA0 [ INTERPRO ]     Q9UNA0 [ UNIPROT ]
Prosite	PS50215 ADAM_MEPRO [ SRS ]    PS50215 ADAM_MEPRO [ Expasy ]
Prosite	PS00427 DISINTEGRIN_1 [ SRS ]    PS00427 DISINTEGRIN_1 [ Expasy ]
Prosite	PS50214 DISINTEGRIN_2 [ SRS ]    PS50214 DISINTEGRIN_2 [ Expasy ]
Prosite	PS50092 TSP1 [ SRS ]    PS50092 TSP1 [ Expasy ]
Prosite	PS00142 ZINC_PROTEASE [ SRS ]    PS00142 ZINC_PROTEASE [ Expasy ]
Interpro	IPR010294 ADAM_spacer1 [ SRS ]    IPR010294 ADAM_spacer1 [ EBI ]
Interpro	IPR001762 Blood-coag_inhib_Disintegrin [ SRS ]    IPR001762 Blood-coag_inhib_Disintegrin [ EBI ]
Interpro	IPR013276 Pept_M12B_ADAM-TS5 [ SRS ]    IPR013276 Pept_M12B_ADAM-TS5 [ EBI ]
Interpro	IPR006025 Pept_M_Zn_BS [ SRS ]    IPR006025 Pept_M_Zn_BS [ EBI ]
Interpro	IPR001590 Peptidase_M12B [ SRS ]    IPR001590 Peptidase_M12B [ EBI ]
Interpro	IPR013273 Peptidase_M12B_ADAM-TS [ SRS ]    IPR013273 Peptidase_M12B_ADAM-TS [ EBI ]
Interpro	IPR002870 Peptidase_M12B_N [ SRS ]    IPR002870 Peptidase_M12B_N [ EBI ]
Interpro	IPR000884 TSP1 [ SRS ]    IPR000884 TSP1 [ EBI ]
Interpro	IPR008085 TSP_1 [ SRS ]    IPR008085 TSP_1 [ EBI ]
CluSTr	Q9UNA0
Pfam	PF05986 ADAM_spacer1 [ SRS ]    PF05986 ADAM_spacer1 [ Sanger ]    pfam05986 [ NCBI-CDD ]
Pfam	PF01562 Pep_M12B_propep [ SRS ]    PF01562 Pep_M12B_propep [ Sanger ]    pfam01562 [ NCBI-CDD ]
Pfam	PF01421 Reprolysin [ SRS ]    PF01421 Reprolysin [ Sanger ]    pfam01421 [ NCBI-CDD ]
Pfam	PF00090 TSP_1 [ SRS ]    PF00090 TSP_1 [ Sanger ]    pfam00090 [ NCBI-CDD ]
Smart	SM00209 TSP1 [EMBL]
Blocks	Q9UNA0
PDB	2RJQ [ SRS ]    2RJQ [ PdbSum ],   2RJQ [ IMB ]   2RJQ [ RSDB ]
PDB	3B8Z [ SRS ]    3B8Z [ PdbSum ],   3B8Z [ IMB ]   3B8Z [ RSDB ]
HPRD	05420
	Protein Interaction databases
DIP	Q9UNA0
IntAct	Q9UNA0
	Polymorphism : SNP, mutations, diseases
OMIM	605007    [ map ]
GENECLINICS	605007
SNP	ADAMTS5 [dbSNP-NCBI]
SNP	NM_007038 [SNP-NCI]
SNP	ADAMTS5 [GeneSNPs - Utah]  ADAMTS5] [HGBASE - SRS]
HAPMAP	ADAMTS5 [HAPMAP]
COSMIC	ADAMTS5 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ADAMTS5
	General knowledge
Family Browser	ADAMTS5 [UCSC Family Browser]
SOURCE	NM_007038
SMD	Hs.58324
SAGE	Hs.58324
Enzyme	3.4.24.- [ Enzyme-Expasy ]   3.4.24.- [ Enzyme-SRS ]   3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   3.4.24.- [ WIT ]
GO	metalloendopeptidase activity [Amigo]  metalloendopeptidase activity
GO	integrin binding [Amigo]  integrin binding
GO	extracellular region [Amigo]  extracellular region
GO	proteinaceous extracellular matrix [Amigo]  proteinaceous extracellular matrix
GO	proteolysis [Amigo]  proteolysis
GO	zinc ion binding [Amigo]  zinc ion binding
GO	metal ion binding [Amigo]  metal ion binding
PubGene	ADAMTS5
TreeFam	ADAMTS5
CTD	11096 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ADAMTS5 Related clones (RZPD - Berlin)
	PubMed
PubMed	30 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 19:59:03 2008