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ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5)

Identity

Alias_namesa disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif
Alias_symbol (synonym)ADMP-2
ADAMTS11
Other aliasADAM-TS 11
ADAM-TS 5
ADAM-TS5
ADAMTS-11
ADAMTS-5
HGNC (Hugo) ADAMTS5
LocusID (NCBI) 11096
Atlas_Id 46151
Location 21q21.3  [Link to chromosome band 21q21]
Location_base_pair Starts at 26917912 and ends at 26967120 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAMTS5 (21q21.3) / GTF3C3 (2q33.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAMTS5   221
Cards
Entrez_Gene (NCBI)ADAMTS5  11096  ADAM metallopeptidase with thrombospondin type 1 motif 5
AliasesADAM-TS; ADAM-TS; ADAM-TS5; ADAMTS-11; 
ADAMTS-5; ADAMTS11; ADMP-2
GeneCards (Weizmann)ADAMTS5
Ensembl hg19 (Hinxton)ENSG00000154736 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154736 [Gene_View]  chr21:26917912-26967120 [Contig_View]  ADAMTS5 [Vega]
ICGC DataPortalENSG00000154736
TCGA cBioPortalADAMTS5
AceView (NCBI)ADAMTS5
Genatlas (Paris)ADAMTS5
WikiGenes11096
SOURCE (Princeton)ADAMTS5
Genetics Home Reference (NIH)ADAMTS5
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTS5  -     chr21:26917912-26967120 -  21q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTS5  -     21q21.3   [Description]    (hg19-Feb_2009)
EnsemblADAMTS5 - 21q21.3 [CytoView hg19]  ADAMTS5 - 21q21.3 [CytoView hg38]
Mapping of homologs : NCBIADAMTS5 [Mapview hg19]  ADAMTS5 [Mapview hg38]
OMIM605007   
Gene and transcription
Genbank (Entrez)AF086299 AF086358 AF141293 AF142099 AK094057
RefSeq transcript (Entrez)NM_007038
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAMTS5
Cluster EST : UnigeneHs.58324 [ NCBI ]
CGAP (NCI)Hs.58324
Alternative Splicing GalleryENSG00000154736
Gene ExpressionADAMTS5 [ NCBI-GEO ]   ADAMTS5 [ EBI - ARRAY_EXPRESS ]   ADAMTS5 [ SEEK ]   ADAMTS5 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11096
GTEX Portal (Tissue expression)ADAMTS5
Human Protein AtlasENSG00000154736-ADAMTS5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNA0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNA0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNA0
Splice isoforms : SwissVarQ9UNA0
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9UNA0
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM_Cys-rich    ADAM_spacer1    MetalloPept_cat_dom    Pept_M12B_ADAM-TS5    Peptidase_M12B    Peptidase_M12B_ADAM-TS    Peptidase_M12B_N    TSP1_rpt   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam01562    pfam01421    pfam00090   
Domain families : Smart (EMBL)ACR (SM00608)  TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS5
DMDM Disease mutations11096
Blocks (Seattle)ADAMTS5
PDB (SRS)2RJQ    3B8Z    3HY7    3HY9    3HYG    3LJT   
PDB (PDBSum)2RJQ    3B8Z    3HY7    3HY9    3HYG    3LJT   
PDB (IMB)2RJQ    3B8Z    3HY7    3HY9    3HYG    3LJT   
PDB (RSDB)2RJQ    3B8Z    3HY7    3HY9    3HYG    3LJT   
Structural Biology KnowledgeBase2RJQ    3B8Z    3HY7    3HY9    3HYG    3LJT   
SCOP (Structural Classification of Proteins)2RJQ    3B8Z    3HY7    3HY9    3HYG    3LJT   
CATH (Classification of proteins structures)2RJQ    3B8Z    3HY7    3HY9    3HYG    3LJT   
SuperfamilyQ9UNA0
Human Protein Atlas [tissue]ENSG00000154736-ADAMTS5 [tissue]
Peptide AtlasQ9UNA0
HPRD05420
IPIIPI00009143   
Protein Interaction databases
DIP (DOE-UCLA)Q9UNA0
IntAct (EBI)Q9UNA0
FunCoupENSG00000154736
BioGRIDADAMTS5
STRING (EMBL)ADAMTS5
ZODIACADAMTS5
Ontologies - Pathways
QuickGOQ9UNA0
Ontology : AmiGOmetalloendopeptidase activity  integrin binding  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  endoplasmic reticulum lumen  proteolysis  heparin binding  metallopeptidase activity  zinc ion binding  extracellular matrix disassembly  protein O-linked fucosylation  defense response to bacterium  tooth eruption  extracellular matrix binding  
Ontology : EGO-EBImetalloendopeptidase activity  integrin binding  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  endoplasmic reticulum lumen  proteolysis  heparin binding  metallopeptidase activity  zinc ion binding  extracellular matrix disassembly  protein O-linked fucosylation  defense response to bacterium  tooth eruption  extracellular matrix binding  
NDEx NetworkADAMTS5
Atlas of Cancer Signalling NetworkADAMTS5
Wikipedia pathwaysADAMTS5
Orthology - Evolution
OrthoDB11096
GeneTree (enSembl)ENSG00000154736
Phylogenetic Trees/Animal Genes : TreeFamADAMTS5
HOVERGENQ9UNA0
HOGENOMQ9UNA0
Homologs : HomoloGeneADAMTS5
Homology/Alignments : Family Browser (UCSC)ADAMTS5
Gene fusions - Rearrangements
Tumor Fusion PortalADAMTS5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS5
dbVarADAMTS5
ClinVarADAMTS5
1000_GenomesADAMTS5 
Exome Variant ServerADAMTS5
ExAC (Exome Aggregation Consortium)ENSG00000154736
GNOMAD BrowserENSG00000154736
Genetic variants : HAPMAP11096
Genomic Variants (DGV)ADAMTS5 [DGVbeta]
DECIPHERADAMTS5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTS5 
Mutations
ICGC Data PortalADAMTS5 
TCGA Data PortalADAMTS5 
Broad Tumor PortalADAMTS5
OASIS PortalADAMTS5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAMTS5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAMTS5
DgiDB (Drug Gene Interaction Database)ADAMTS5
DoCM (Curated mutations)ADAMTS5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS5 (select a term)
intoGenADAMTS5
Cancer3DADAMTS5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605007   
Orphanet
DisGeNETADAMTS5
MedgenADAMTS5
Genetic Testing Registry ADAMTS5
NextProtQ9UNA0 [Medical]
TSGene11096
GENETestsADAMTS5
Target ValidationADAMTS5
Huge Navigator ADAMTS5 [HugePedia]
snp3D : Map Gene to Disease11096
BioCentury BCIQADAMTS5
ClinGenADAMTS5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11096
Chemical/Pharm GKB GenePA24549
Clinical trialADAMTS5
Miscellaneous
canSAR (ICR)ADAMTS5 (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAMTS5
EVEXADAMTS5
GoPubMedADAMTS5
iHOPADAMTS5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:02:06 CET 2017

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