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ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6)

Identity

Alias (NCBI)ADAM-TS 6
ADAM-TS6
ADAMTS-6
HGNC (Hugo) ADAMTS6
HGNC Alias symbADAM-TS6
HGNC Alias namea disintegrin and metalloproteinase with thrombospondin motifs 6
HGNC Previous namea disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6
LocusID (NCBI) 11174
Atlas_Id 47282
Location 5q12.3  [Link to chromosome band 5q12]
Location_base_pair Starts at 65148738 and ends at 65481920 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ADAMTS6   222
Cards
Entrez_Gene (NCBI)ADAMTS6    ADAM metallopeptidase with thrombospondin type 1 motif 6
AliasesADAM-TS; ADAM-TS6; ADAMTS-6
GeneCards (Weizmann)ADAMTS6
Ensembl hg19 (Hinxton)ENSG00000049192 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000049192 [Gene_View]  ENSG00000049192 [Sequence]  chr5:65148738-65481920 [Contig_View]  ADAMTS6 [Vega]
ICGC DataPortalENSG00000049192
TCGA cBioPortalADAMTS6
AceView (NCBI)ADAMTS6
Genatlas (Paris)ADAMTS6
SOURCE (Princeton)ADAMTS6
Genetics Home Reference (NIH)ADAMTS6
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTS6  -     chr5:65148738-65481920 -  5q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTS6  -     5q12.3   [Description]    (hg19-Feb_2009)
GoldenPathADAMTS6 - 5q12.3 [CytoView hg19]  ADAMTS6 - 5q12.3 [CytoView hg38]
ImmunoBaseENSG00000049192
Genome Data Viewer NCBIADAMTS6 [Mapview hg19]  
OMIM605008   
Gene and transcription
Genbank (Entrez)AA318687 AA333577 AA907572 AB209685 AF140674
RefSeq transcript (Entrez)NM_197941
Consensus coding sequences : CCDS (NCBI)ADAMTS6
Gene ExpressionADAMTS6 [ NCBI-GEO ]   ADAMTS6 [ EBI - ARRAY_EXPRESS ]   ADAMTS6 [ SEEK ]   ADAMTS6 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS6 [ Firebrowse - Broad ]
GenevisibleExpression of ADAMTS6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11174
GTEX Portal (Tissue expression)ADAMTS6
Human Protein AtlasENSG00000049192-ADAMTS6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKP5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKP5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKP5
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UKP5
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    PLAC (PS50900)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM_CR_2    ADAM_spacer1    ADAMTS/ADAMTS-like    MetalloPept_cat_dom_sf    Peptidase_M12B    Peptidase_M12B_N    PLAC    TSP1_rpt    TSP1_rpt_sf   
Domain families : Pfam (Sanger)ADAM_CR_2 (PF17771)    ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    PLAC (PF08686)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam17771    pfam05986    pfam01562    pfam08686    pfam01421    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS6
SuperfamilyQ9UKP5
AlphaFold pdb e-kbQ9UKP5   
Human Protein Atlas [tissue]ENSG00000049192-ADAMTS6 [tissue]
HPRD05421
Protein Interaction databases
DIP (DOE-UCLA)Q9UKP5
IntAct (EBI)Q9UKP5
BioGRIDADAMTS6
STRING (EMBL)ADAMTS6
ZODIACADAMTS6
Ontologies - Pathways
QuickGOQ9UKP5
Ontology : AmiGOkidney development  cardiac septum development  metalloendopeptidase activity  extracellular region  proteolysis  metallopeptidase activity  extracellular matrix organization  extracellular matrix  aorta development  metal ion binding  coronary vasculature development  
Ontology : EGO-EBIkidney development  cardiac septum development  metalloendopeptidase activity  extracellular region  proteolysis  metallopeptidase activity  extracellular matrix organization  extracellular matrix  aorta development  metal ion binding  coronary vasculature development  
NDEx NetworkADAMTS6
Atlas of Cancer Signalling NetworkADAMTS6
Wikipedia pathwaysADAMTS6
Orthology - Evolution
OrthoDB11174
GeneTree (enSembl)ENSG00000049192
Phylogenetic Trees/Animal Genes : TreeFamADAMTS6
Homologs : HomoloGeneADAMTS6
Homology/Alignments : Family Browser (UCSC)ADAMTS6
Gene fusions - Rearrangements
Fusion : QuiverADAMTS6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS6
dbVarADAMTS6
ClinVarADAMTS6
MonarchADAMTS6
1000_GenomesADAMTS6 
Exome Variant ServerADAMTS6
GNOMAD BrowserENSG00000049192
Varsome BrowserADAMTS6
ACMGADAMTS6 variants
VarityQ9UKP5
Genomic Variants (DGV)ADAMTS6 [DGVbeta]
DECIPHERADAMTS6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTS6 
Mutations
ICGC Data PortalADAMTS6 
TCGA Data PortalADAMTS6 
Broad Tumor PortalADAMTS6
OASIS PortalADAMTS6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DADAMTS6
Mutations and Diseases : HGMDADAMTS6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaADAMTS6
DgiDB (Drug Gene Interaction Database)ADAMTS6
DoCM (Curated mutations)ADAMTS6
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS6
Cancer3DADAMTS6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605008   
Orphanet
DisGeNETADAMTS6
MedgenADAMTS6
Genetic Testing Registry ADAMTS6
NextProtQ9UKP5 [Medical]
GENETestsADAMTS6
Target ValidationADAMTS6
Huge Navigator ADAMTS6 [HugePedia]
ClinGenADAMTS6
Clinical trials, drugs, therapy
MyCancerGenomeADAMTS6
Protein Interactions : CTDADAMTS6
Pharm GKB GenePA24550
PharosQ9UKP5
Clinical trialADAMTS6
Miscellaneous
canSAR (ICR)ADAMTS6
HarmonizomeADAMTS6
DataMed IndexADAMTS6
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXADAMTS6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:58:29 CEST 2021

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