ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6)

2007-04-01  

Identity

HGNC
ADAMTS6
LOCATION
5q12.3
LOCUSID
11174
ALIAS
ADAM-TS

Other Information

Locus ID:

NCBI: 11174
MIM: 605008
HGNC: 222
Ensembl: ENSG00000049192

Variants:

dbSNP: 11174
ClinVar: 11174
TCGA: ENSG00000049192
COSMIC: ADAMTS6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000049192ENST00000381052Q9UKP5
ENSG00000049192ENST00000381055Q9UKP5

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-glycosylation of TSR domain-containing proteinsREACTOMER-HSA-5173214
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective B3GALTL causes Peters-plus syndrome (PpS)REACTOMER-HSA-5083635

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368107122023The role of ADAMTS6 and ADAMTS17 polymorphisms in susceptibility to lumbar disc herniation in Chinese Han population.0
368107122023The role of ADAMTS6 and ADAMTS17 polymorphisms in susceptibility to lumbar disc herniation in Chinese Han population.0
338517082021Identified a disintegrin and metalloproteinase with thrombospondin motifs 6 serve as a novel gastric cancer prognostic biomarker by bioinformatics analysis.4
338517082021Identified a disintegrin and metalloproteinase with thrombospondin motifs 6 serve as a novel gastric cancer prognostic biomarker by bioinformatics analysis.4
294750362018ADAMTS-6 is a predictor of poor prognosis in patients with esophageal squamous cell carcinoma.12
300122202018Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.29
294750362018ADAMTS-6 is a predictor of poor prognosis in patients with esophageal squamous cell carcinoma.12
300122202018Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.29
275422242016ADAMTS6 suppresses tumor progression via the ERK signaling pathway and serves as a prognostic marker in human breast cancer.16
277792342016ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions.39
275422242016ADAMTS6 suppresses tumor progression via the ERK signaling pathway and serves as a prognostic marker in human breast cancer.16
277792342016ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions.39
266865532015A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia.38
266865532015A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia.38
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47282/adamts6