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ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6)

Identity

Alias_namesa disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif
Alias_symbol (synonym)ADAM-TS6
Other aliasADAM-TS 6
ADAMTS-6
HGNC (Hugo) ADAMTS6
LocusID (NCBI) 11174
Atlas_Id 47282
Location 5q12.3  [Link to chromosome band 5q12]
Location_base_pair Starts at 65148736 and ends at 65481920 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAMTS6   222
Cards
Entrez_Gene (NCBI)ADAMTS6  11174  ADAM metallopeptidase with thrombospondin type 1 motif 6
AliasesADAM-TS; ADAM-TS6; ADAMTS-6
GeneCards (Weizmann)ADAMTS6
Ensembl hg19 (Hinxton)ENSG00000049192 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000049192 [Gene_View]  chr5:65148736-65481920 [Contig_View]  ADAMTS6 [Vega]
ICGC DataPortalENSG00000049192
TCGA cBioPortalADAMTS6
AceView (NCBI)ADAMTS6
Genatlas (Paris)ADAMTS6
WikiGenes11174
SOURCE (Princeton)ADAMTS6
Genetics Home Reference (NIH)ADAMTS6
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTS6  -     chr5:65148736-65481920 -  5q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTS6  -     5q12.3   [Description]    (hg19-Feb_2009)
EnsemblADAMTS6 - 5q12.3 [CytoView hg19]  ADAMTS6 - 5q12.3 [CytoView hg38]
Mapping of homologs : NCBIADAMTS6 [Mapview hg19]  ADAMTS6 [Mapview hg38]
OMIM605008   
Gene and transcription
Genbank (Entrez)AA318687 AA333577 AA907572 AB209685 AF140674
RefSeq transcript (Entrez)NM_197941
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAMTS6
Cluster EST : UnigeneHs.482291 [ NCBI ]
CGAP (NCI)Hs.482291
Alternative Splicing GalleryENSG00000049192
Gene ExpressionADAMTS6 [ NCBI-GEO ]   ADAMTS6 [ EBI - ARRAY_EXPRESS ]   ADAMTS6 [ SEEK ]   ADAMTS6 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11174
GTEX Portal (Tissue expression)ADAMTS6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKP5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKP5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKP5
Splice isoforms : SwissVarQ9UKP5
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9UKP5
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    PLAC (PS50900)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM_spacer1    MetalloPept_cat_dom    Peptidase_M12B    Peptidase_M12B_ADAM-TS    Peptidase_M12B_N    PLAC    TSP1_rpt   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    PLAC (PF08686)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam01562    pfam08686    pfam01421    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS6
DMDM Disease mutations11174
Blocks (Seattle)ADAMTS6
SuperfamilyQ9UKP5
Human Protein AtlasENSG00000049192
Peptide AtlasQ9UKP5
HPRD05421
IPIIPI00658047   IPI00296965   IPI00967682   IPI00929566   IPI00375352   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKP5
IntAct (EBI)Q9UKP5
FunCoupENSG00000049192
BioGRIDADAMTS6
STRING (EMBL)ADAMTS6
ZODIACADAMTS6
Ontologies - Pathways
QuickGOQ9UKP5
Ontology : AmiGOcardiac septum development  metalloendopeptidase activity  proteinaceous extracellular matrix  proteolysis  metallopeptidase activity  zinc ion binding  aorta development  coronary vasculature development  
Ontology : EGO-EBIcardiac septum development  metalloendopeptidase activity  proteinaceous extracellular matrix  proteolysis  metallopeptidase activity  zinc ion binding  aorta development  coronary vasculature development  
NDEx NetworkADAMTS6
Atlas of Cancer Signalling NetworkADAMTS6
Wikipedia pathwaysADAMTS6
Orthology - Evolution
OrthoDB11174
GeneTree (enSembl)ENSG00000049192
Phylogenetic Trees/Animal Genes : TreeFamADAMTS6
HOVERGENQ9UKP5
HOGENOMQ9UKP5
Homologs : HomoloGeneADAMTS6
Homology/Alignments : Family Browser (UCSC)ADAMTS6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS6
dbVarADAMTS6
ClinVarADAMTS6
1000_GenomesADAMTS6 
Exome Variant ServerADAMTS6
ExAC (Exome Aggregation Consortium)ADAMTS6 (select the gene name)
Genetic variants : HAPMAP11174
Genomic Variants (DGV)ADAMTS6 [DGVbeta]
DECIPHERADAMTS6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTS6 
Mutations
ICGC Data PortalADAMTS6 
TCGA Data PortalADAMTS6 
Broad Tumor PortalADAMTS6
OASIS PortalADAMTS6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAMTS6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAMTS6
DgiDB (Drug Gene Interaction Database)ADAMTS6
DoCM (Curated mutations)ADAMTS6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS6 (select a term)
intoGenADAMTS6
Cancer3DADAMTS6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605008   
Orphanet
MedgenADAMTS6
Genetic Testing Registry ADAMTS6
NextProtQ9UKP5 [Medical]
TSGene11174
GENETestsADAMTS6
Target ValidationADAMTS6
Huge Navigator ADAMTS6 [HugePedia]
snp3D : Map Gene to Disease11174
BioCentury BCIQADAMTS6
ClinGenADAMTS6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11174
Chemical/Pharm GKB GenePA24550
Clinical trialADAMTS6
Miscellaneous
canSAR (ICR)ADAMTS6 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAMTS6
EVEXADAMTS6
GoPubMedADAMTS6
iHOPADAMTS6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:54:24 CEST 2017

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