ADAMTS7 (ADAM metallopeptidase with thrombospondin type 1 motif 7)

2007-04-01  

Identity

HGNC
LOCATION
15q25.1
LOCUSID
ALIAS
ADAM-TS

Other Information

Locus ID:

NCBI: 11173
MIM: 605009
HGNC: 223
Ensembl: ENSG00000136378

Variants:

dbSNP: 11173
ClinVar: 11173
TCGA: ENSG00000136378
COSMIC: ADAMTS7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136378ENST00000388820Q9UKP4

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-glycosylation of TSR domain-containing proteinsREACTOMER-HSA-5173214
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective B3GALTL causes Peters-plus syndrome (PpS)REACTOMER-HSA-5083635

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
212390512011Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.161
194874642009ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor.51
165850642006ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein.49
190989272009The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.30
234156692013ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant.30
257122062015Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice.26
268162502016miR-105/Runx2 axis mediates FGF2-induced ADAMTS expression in osteoarthritis cartilage.24
207187942011Association of polymorphisms in 9p21 region with CAD in North Indian population: replication of SNPs identified through GWAS.16
284616242017Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions.12
258859612015Association between plasma ADAMTS-7 levels and ventricular remodeling in patients with acute myocardial infarction.9

Citation

Dessen P

ADAMTS7 (ADAM metallopeptidase with thrombospondin type 1 motif 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47045/adamts7