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ADAMTS7 (ADAM metallopeptidase with thrombospondin type 1 motif 7)

Identity

Alias_namesa disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif
Alias_symbol (synonym)ADAM-TS7
DKFZp434H204
Other aliasADAM-TS 7
ADAMTS-7
HGNC (Hugo) ADAMTS7
LocusID (NCBI) 11173
Atlas_Id 47045
Location 5q12.3  [Link to chromosome band 5q12]
Location_base_pair Starts at 78759203 and ends at 78811463 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ADAMTS7   223
Cards
Entrez_Gene (NCBI)ADAMTS7  11173  ADAM metallopeptidase with thrombospondin type 1 motif 7
AliasesADAM-TS; ADAM-TS7; ADAMTS-7
GeneCards (Weizmann)ADAMTS7
Ensembl hg19 (Hinxton)ENSG00000136378 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136378 [Gene_View]  ENSG00000136378 [Sequence]  chr15:78759203-78811463 [Contig_View]  ADAMTS7 [Vega]
ICGC DataPortalENSG00000136378
TCGA cBioPortalADAMTS7
AceView (NCBI)ADAMTS7
Genatlas (Paris)ADAMTS7
WikiGenes11173
SOURCE (Princeton)ADAMTS7
Genetics Home Reference (NIH)ADAMTS7
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTS7  -     chr15:78759203-78811463 -  5q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTS7  -     5q12.3   [Description]    (hg19-Feb_2009)
EnsemblADAMTS7 - 5q12.3 [CytoView hg19]  ADAMTS7 - 5q12.3 [CytoView hg38]
Mapping of homologs : NCBIADAMTS7 [Mapview hg19]  ADAMTS7 [Mapview hg38]
OMIM605009   
Gene and transcription
Genbank (Entrez)AB209497 AF140675 AK299844 AL110226 AL359934
RefSeq transcript (Entrez)NM_014272
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAMTS7
Cluster EST : UnigeneHs.16441 [ NCBI ]
CGAP (NCI)Hs.16441
Alternative Splicing GalleryENSG00000136378
Gene ExpressionADAMTS7 [ NCBI-GEO ]   ADAMTS7 [ EBI - ARRAY_EXPRESS ]   ADAMTS7 [ SEEK ]   ADAMTS7 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11173
GTEX Portal (Tissue expression)ADAMTS7
Human Protein AtlasENSG00000136378-ADAMTS7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKP4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKP4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKP4
Splice isoforms : SwissVarQ9UKP4
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9UKP4
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    PLAC (PS50900)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM_spacer1    MetalloPept_cat_dom_sf    Peptidase_M12B    Peptidase_M12B_N    PLAC    TSP1_rpt    TSP1_rpt_sf   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam01562    pfam01421    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS7
DMDM Disease mutations11173
Blocks (Seattle)ADAMTS7
SuperfamilyQ9UKP4
Human Protein Atlas [tissue]ENSG00000136378-ADAMTS7 [tissue]
Peptide AtlasQ9UKP4
HPRD05422
IPIIPI00395970   IPI00910332   IPI00556198   IPI00981394   IPI00007692   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKP4
IntAct (EBI)Q9UKP4
FunCoupENSG00000136378
BioGRIDADAMTS7
STRING (EMBL)ADAMTS7
ZODIACADAMTS7
Ontologies - Pathways
QuickGOQ9UKP4
Ontology : AmiGOmetalloendopeptidase activity  protein binding  extracellular region  endoplasmic reticulum lumen  metallopeptidase activity  cell surface  negative regulation of chondrocyte differentiation  metal ion binding  proteolysis involved in cellular protein catabolic process  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to BMP stimulus  
Ontology : EGO-EBImetalloendopeptidase activity  protein binding  extracellular region  endoplasmic reticulum lumen  metallopeptidase activity  cell surface  negative regulation of chondrocyte differentiation  metal ion binding  proteolysis involved in cellular protein catabolic process  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to BMP stimulus  
NDEx NetworkADAMTS7
Atlas of Cancer Signalling NetworkADAMTS7
Wikipedia pathwaysADAMTS7
Orthology - Evolution
OrthoDB11173
GeneTree (enSembl)ENSG00000136378
Phylogenetic Trees/Animal Genes : TreeFamADAMTS7
HOVERGENQ9UKP4
HOGENOMQ9UKP4
Homologs : HomoloGeneADAMTS7
Homology/Alignments : Family Browser (UCSC)ADAMTS7
Gene fusions - Rearrangements
Fusion : QuiverADAMTS7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS7
dbVarADAMTS7
ClinVarADAMTS7
1000_GenomesADAMTS7 
Exome Variant ServerADAMTS7
ExAC (Exome Aggregation Consortium)ENSG00000136378
GNOMAD BrowserENSG00000136378
Varsome BrowserADAMTS7
Genetic variants : HAPMAP11173
Genomic Variants (DGV)ADAMTS7 [DGVbeta]
DECIPHERADAMTS7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTS7 
Mutations
ICGC Data PortalADAMTS7 
TCGA Data PortalADAMTS7 
Broad Tumor PortalADAMTS7
OASIS PortalADAMTS7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAMTS7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAMTS7
DgiDB (Drug Gene Interaction Database)ADAMTS7
DoCM (Curated mutations)ADAMTS7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS7 (select a term)
intoGenADAMTS7
Cancer3DADAMTS7(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605009   
Orphanet
DisGeNETADAMTS7
MedgenADAMTS7
Genetic Testing Registry ADAMTS7
NextProtQ9UKP4 [Medical]
TSGene11173
GENETestsADAMTS7
Target ValidationADAMTS7
Huge Navigator ADAMTS7 [HugePedia]
snp3D : Map Gene to Disease11173
BioCentury BCIQADAMTS7
ClinGenADAMTS7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11173
Chemical/Pharm GKB GenePA24551
Clinical trialADAMTS7
Miscellaneous
canSAR (ICR)ADAMTS7 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAMTS7
EVEXADAMTS7
GoPubMedADAMTS7
iHOPADAMTS7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Aug 16 10:45:23 CEST 2018
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