Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ADAMTS8 (ADAM metallopeptidase with thrombospondin type 1 motif 8)

Identity

Alias_namesa disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif
Alias_symbol (synonym)METH2
FLJ41712
ADAM-TS8
Other alias
HGNC (Hugo) ADAMTS8
LocusID (NCBI) 11095
Atlas_Id 576
Location 11q24.3  [Link to chromosome band 11q24]
Location_base_pair Starts at 130404923 and ends at 130428993 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAMTS8   224
Cards
Entrez_Gene (NCBI)ADAMTS8  11095  ADAM metallopeptidase with thrombospondin type 1 motif 8
AliasesADAM-TS8; METH2
GeneCards (Weizmann)ADAMTS8
Ensembl hg19 (Hinxton)ENSG00000134917 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134917 [Gene_View]  ENSG00000134917 [Sequence]  chr11:130404923-130428993 [Contig_View]  ADAMTS8 [Vega]
ICGC DataPortalENSG00000134917
TCGA cBioPortalADAMTS8
AceView (NCBI)ADAMTS8
Genatlas (Paris)ADAMTS8
WikiGenes11095
SOURCE (Princeton)ADAMTS8
Genetics Home Reference (NIH)ADAMTS8
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTS8  -     chr11:130404923-130428993 -  11q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTS8  -     11q24.3   [Description]    (hg19-Feb_2009)
GoldenPathADAMTS8 - 11q24.3 [CytoView hg19]  ADAMTS8 - 11q24.3 [CytoView hg38]
ImmunoBaseENSG00000134917
Mapping of homologs : NCBIADAMTS8 [Mapview hg19]  ADAMTS8 [Mapview hg38]
OMIM605175   
Gene and transcription
Genbank (Entrez)AB209717 AF060153 AF175283 AK123706 BC089435
RefSeq transcript (Entrez)NM_007037
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAMTS8
Cluster EST : UnigeneHs.271605 [ NCBI ]
CGAP (NCI)Hs.271605
Alternative Splicing GalleryENSG00000134917
Gene ExpressionADAMTS8 [ NCBI-GEO ]   ADAMTS8 [ EBI - ARRAY_EXPRESS ]   ADAMTS8 [ SEEK ]   ADAMTS8 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11095
GTEX Portal (Tissue expression)ADAMTS8
Human Protein AtlasENSG00000134917-ADAMTS8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UP79   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UP79  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UP79
Splice isoforms : SwissVarQ9UP79
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9UP79
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    TSP1 (PS50092)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ADAM_Cys-rich    ADAM_spacer1    MetalloPept_cat_dom_sf    Pept_M12B_ADAM-TS8    Peptidase_M12B    Peptidase_M12B_N    TSP1_rpt    TSP1_rpt_sf   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam01562    pfam01421    pfam00090   
Domain families : Smart (EMBL)ACR (SM00608)  TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS8
DMDM Disease mutations11095
Blocks (Seattle)ADAMTS8
SuperfamilyQ9UP79
Human Protein Atlas [tissue]ENSG00000134917-ADAMTS8 [tissue]
Peptide AtlasQ9UP79
HPRD05531
IPIIPI00874035   IPI00298650   IPI00976957   
Protein Interaction databases
DIP (DOE-UCLA)Q9UP79
IntAct (EBI)Q9UP79
FunCoupENSG00000134917
BioGRIDADAMTS8
STRING (EMBL)ADAMTS8
ZODIACADAMTS8
Ontologies - Pathways
QuickGOQ9UP79
Ontology : AmiGOmetalloendopeptidase activity  integrin binding  proteolysis  heparin binding  metallopeptidase activity  zinc ion binding  negative regulation of cell proliferation  low-affinity phosphate transmembrane transporter activity  phosphate ion transmembrane transport  collagen-containing extracellular matrix  
Ontology : EGO-EBImetalloendopeptidase activity  integrin binding  proteolysis  heparin binding  metallopeptidase activity  zinc ion binding  negative regulation of cell proliferation  low-affinity phosphate transmembrane transporter activity  phosphate ion transmembrane transport  collagen-containing extracellular matrix  
NDEx NetworkADAMTS8
Atlas of Cancer Signalling NetworkADAMTS8
Wikipedia pathwaysADAMTS8
Orthology - Evolution
OrthoDB11095
GeneTree (enSembl)ENSG00000134917
Phylogenetic Trees/Animal Genes : TreeFamADAMTS8
HOGENOMQ9UP79
Homologs : HomoloGeneADAMTS8
Homology/Alignments : Family Browser (UCSC)ADAMTS8
Gene fusions - Rearrangements
Fusion : QuiverADAMTS8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS8
dbVarADAMTS8
ClinVarADAMTS8
1000_GenomesADAMTS8 
Exome Variant ServerADAMTS8
ExAC (Exome Aggregation Consortium)ENSG00000134917
GNOMAD BrowserENSG00000134917
Varsome BrowserADAMTS8
Genetic variants : HAPMAP11095
Genomic Variants (DGV)ADAMTS8 [DGVbeta]
DECIPHERADAMTS8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTS8 
Mutations
ICGC Data PortalADAMTS8 
TCGA Data PortalADAMTS8 
Broad Tumor PortalADAMTS8
OASIS PortalADAMTS8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAMTS8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAMTS8
DgiDB (Drug Gene Interaction Database)ADAMTS8
DoCM (Curated mutations)ADAMTS8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS8 (select a term)
intoGenADAMTS8
Cancer3DADAMTS8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605175   
Orphanet
DisGeNETADAMTS8
MedgenADAMTS8
Genetic Testing Registry ADAMTS8
NextProtQ9UP79 [Medical]
TSGene11095
GENETestsADAMTS8
Target ValidationADAMTS8
Huge Navigator ADAMTS8 [HugePedia]
snp3D : Map Gene to Disease11095
BioCentury BCIQADAMTS8
ClinGenADAMTS8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11095
Chemical/Pharm GKB GenePA24552
Clinical trialADAMTS8
Miscellaneous
canSAR (ICR)ADAMTS8 (select the gene name)
DataMed IndexADAMTS8
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAMTS8
EVEXADAMTS8
GoPubMedADAMTS8
iHOPADAMTS8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jul 8 11:09:39 CEST 2019

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.