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ADAMTSL4 (ADAMTS like 4)

Identity

Alias_namesTSRC1
thrombospondin repeat containing 1
Alias_symbol (synonym)DKFZP434K1772
Other aliasADAMTSL-4
ECTOL2
HGNC (Hugo) ADAMTSL4
LocusID (NCBI) 54507
Atlas_Id 60145
Location 1q21.2  [Link to chromosome band 1q21]
Location_base_pair Starts at 150549369 and ends at 150560936 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADAMTSL4 (1q21.3) / ADAMTSL4 (1q21.3)ADAMTSL4 (1q21.3) / MAT2A (2p11.2)SCAF1 (19q13.33) / ADAMTSL4 (1q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAMTSL4   19706
Cards
Entrez_Gene (NCBI)ADAMTSL4  54507  ADAMTS like 4
AliasesADAMTSL-4; ECTOL2; TSRC1
GeneCards (Weizmann)ADAMTSL4
Ensembl hg19 (Hinxton)ENSG00000143382 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143382 [Gene_View]  chr1:150549369-150560936 [Contig_View]  ADAMTSL4 [Vega]
ICGC DataPortalENSG00000143382
TCGA cBioPortalADAMTSL4
AceView (NCBI)ADAMTSL4
Genatlas (Paris)ADAMTSL4
WikiGenes54507
SOURCE (Princeton)ADAMTSL4
Genetics Home Reference (NIH)ADAMTSL4
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTSL4  -     chr1:150549369-150560936 +  1q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTSL4  -     1q21.2   [Description]    (hg19-Feb_2009)
EnsemblADAMTSL4 - 1q21.2 [CytoView hg19]  ADAMTSL4 - 1q21.2 [CytoView hg38]
Mapping of homologs : NCBIADAMTSL4 [Mapview hg19]  ADAMTSL4 [Mapview hg38]
OMIM225100   225200   610113   
Gene and transcription
Genbank (Entrez)AF217974 AF289612 AF370411 AI637480 AK023606
RefSeq transcript (Entrez)NM_001288607 NM_001288608 NM_019032 NM_025008
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAMTSL4
Cluster EST : UnigeneHs.516243 [ NCBI ]
CGAP (NCI)Hs.516243
Alternative Splicing GalleryENSG00000143382
Gene ExpressionADAMTSL4 [ NCBI-GEO ]   ADAMTSL4 [ EBI - ARRAY_EXPRESS ]   ADAMTSL4 [ SEEK ]   ADAMTSL4 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTSL4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54507
GTEX Portal (Tissue expression)ADAMTSL4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UY14   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UY14  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UY14
Splice isoforms : SwissVarQ6UY14
PhosPhoSitePlusQ6UY14
Domaine pattern : Prosite (Expaxy)PLAC (PS50900)    TSP1 (PS50092)   
Domains : Interpro (EBI)ADAM_spacer1    PLAC    TSP1_rpt   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    PLAC (PF08686)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam08686    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTSL4
DMDM Disease mutations54507
Blocks (Seattle)ADAMTSL4
SuperfamilyQ6UY14
Human Protein AtlasENSG00000143382
Peptide AtlasQ6UY14
HPRD08583
IPIIPI00374068   IPI00550741   IPI00896415   IPI00435930   IPI00017422   
Protein Interaction databases
DIP (DOE-UCLA)Q6UY14
IntAct (EBI)Q6UY14
FunCoupENSG00000143382
BioGRIDADAMTSL4
STRING (EMBL)ADAMTSL4
ZODIACADAMTSL4
Ontologies - Pathways
QuickGOQ6UY14
Ontology : AmiGOprotease binding  epithelial cell development  metalloendopeptidase activity  protein binding  cellular_component  interstitial matrix  extracellular space  endoplasmic reticulum lumen  proteolysis  apoptotic process  extracellular matrix organization  protein O-linked fucosylation  positive regulation of apoptotic process  
Ontology : EGO-EBIprotease binding  epithelial cell development  metalloendopeptidase activity  protein binding  cellular_component  interstitial matrix  extracellular space  endoplasmic reticulum lumen  proteolysis  apoptotic process  extracellular matrix organization  protein O-linked fucosylation  positive regulation of apoptotic process  
NDEx NetworkADAMTSL4
Atlas of Cancer Signalling NetworkADAMTSL4
Wikipedia pathwaysADAMTSL4
Orthology - Evolution
OrthoDB54507
GeneTree (enSembl)ENSG00000143382
Phylogenetic Trees/Animal Genes : TreeFamADAMTSL4
HOVERGENQ6UY14
HOGENOMQ6UY14
Homologs : HomoloGeneADAMTSL4
Homology/Alignments : Family Browser (UCSC)ADAMTSL4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTSL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTSL4
dbVarADAMTSL4
ClinVarADAMTSL4
1000_GenomesADAMTSL4 
Exome Variant ServerADAMTSL4
ExAC (Exome Aggregation Consortium)ADAMTSL4 (select the gene name)
Genetic variants : HAPMAP54507
Genomic Variants (DGV)ADAMTSL4 [DGVbeta]
DECIPHERADAMTSL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTSL4 
Mutations
ICGC Data PortalADAMTSL4 
TCGA Data PortalADAMTSL4 
Broad Tumor PortalADAMTSL4
OASIS PortalADAMTSL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTSL4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAMTSL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch ADAMTSL4
DgiDB (Drug Gene Interaction Database)ADAMTSL4
DoCM (Curated mutations)ADAMTSL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTSL4 (select a term)
intoGenADAMTSL4
Cancer3DADAMTSL4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM225100    225200    610113   
Orphanet486   
MedgenADAMTSL4
Genetic Testing Registry ADAMTSL4
NextProtQ6UY14 [Medical]
TSGene54507
GENETestsADAMTSL4
Huge Navigator ADAMTSL4 [HugePedia]
snp3D : Map Gene to Disease54507
BioCentury BCIQADAMTSL4
ClinGenADAMTSL4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54507
Chemical/Pharm GKB GenePA134879921
Clinical trialADAMTSL4
Miscellaneous
canSAR (ICR)ADAMTSL4 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAMTSL4
EVEXADAMTSL4
GoPubMedADAMTSL4
iHOPADAMTSL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 10:59:21 CEST 2017

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