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ADAMTSL4 (ADAMTS like 4)

Identity

Alias (NCBI)ADAMTSL-4
ECTOL2
TSRC1
HGNC (Hugo) ADAMTSL4
HGNC Alias symbDKFZP434K1772
HGNC Previous nameTSRC1
HGNC Previous namethrombospondin repeat containing 1
LocusID (NCBI) 54507
Atlas_Id 60145
Location 1q21.2  [Link to chromosome band 1q21]
Location_base_pair Starts at 150549408 and ends at 150558748 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAMTSL4 (1q21.3) / ADAMTSL4 (1q21.3)ADAMTSL4 (1q21.3) / MAT2A (2p11.2)SCAF1 (19q13.33) / ADAMTSL4 (1q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ADAMTSL4   19706
Cards
Entrez_Gene (NCBI)ADAMTSL4    ADAMTS like 4
AliasesADAMTSL-4; ECTOL2; TSRC1
GeneCards (Weizmann)ADAMTSL4
Ensembl hg19 (Hinxton)ENSG00000143382 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143382 [Gene_View]  ENSG00000143382 [Sequence]  chr1:150549408-150558748 [Contig_View]  ADAMTSL4 [Vega]
ICGC DataPortalENSG00000143382
TCGA cBioPortalADAMTSL4
AceView (NCBI)ADAMTSL4
Genatlas (Paris)ADAMTSL4
SOURCE (Princeton)ADAMTSL4
Genetics Home Reference (NIH)ADAMTSL4
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTSL4  -     chr1:150549408-150558748 +  1q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTSL4  -     1q21.2   [Description]    (hg19-Feb_2009)
GoldenPathADAMTSL4 - 1q21.2 [CytoView hg19]  ADAMTSL4 - 1q21.2 [CytoView hg38]
ImmunoBaseENSG00000143382
Genome Data Viewer NCBIADAMTSL4 [Mapview hg19]  
OMIM225100   225200   610113   
Gene and transcription
Genbank (Entrez)AF217974 AF289612 AF370411 AI637480 AK023606
RefSeq transcript (Entrez)NM_001288607 NM_001288608 NM_001378596 NM_019032 NM_025008
Consensus coding sequences : CCDS (NCBI)ADAMTSL4
Gene ExpressionADAMTSL4 [ NCBI-GEO ]   ADAMTSL4 [ EBI - ARRAY_EXPRESS ]   ADAMTSL4 [ SEEK ]   ADAMTSL4 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTSL4 [ Firebrowse - Broad ]
GenevisibleExpression of ADAMTSL4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54507
GTEX Portal (Tissue expression)ADAMTSL4
Human Protein AtlasENSG00000143382-ADAMTSL4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UY14   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UY14  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UY14
PhosPhoSitePlusQ6UY14
Domaine pattern : Prosite (Expaxy)PLAC (PS50900)    TSP1 (PS50092)   
Domains : Interpro (EBI)ADAM_spacer1    PLAC    TSP1_rpt    TSP1_rpt_sf   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    PLAC (PF08686)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam08686    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTSL4
SuperfamilyQ6UY14
AlphaFold pdb e-kbQ6UY14   
Human Protein Atlas [tissue]ENSG00000143382-ADAMTSL4 [tissue]
HPRD08583
Protein Interaction databases
DIP (DOE-UCLA)Q6UY14
IntAct (EBI)Q6UY14
BioGRIDADAMTSL4
STRING (EMBL)ADAMTSL4
ZODIACADAMTSL4
Ontologies - Pathways
QuickGOQ6UY14
Ontology : AmiGOprotease binding  epithelial cell development  metalloendopeptidase activity  protein binding  extracellular region  interstitial matrix  endoplasmic reticulum lumen  proteolysis  apoptotic process  extracellular matrix organization  extracellular matrix  positive regulation of apoptotic process  collagen-containing extracellular matrix  collagen-containing extracellular matrix  
Ontology : EGO-EBIprotease binding  epithelial cell development  metalloendopeptidase activity  protein binding  extracellular region  interstitial matrix  endoplasmic reticulum lumen  proteolysis  apoptotic process  extracellular matrix organization  extracellular matrix  positive regulation of apoptotic process  collagen-containing extracellular matrix  collagen-containing extracellular matrix  
NDEx NetworkADAMTSL4
Atlas of Cancer Signalling NetworkADAMTSL4
Wikipedia pathwaysADAMTSL4
Orthology - Evolution
OrthoDB54507
GeneTree (enSembl)ENSG00000143382
Phylogenetic Trees/Animal Genes : TreeFamADAMTSL4
Homologs : HomoloGeneADAMTSL4
Homology/Alignments : Family Browser (UCSC)ADAMTSL4
Gene fusions - Rearrangements
Fusion : QuiverADAMTSL4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTSL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTSL4
dbVarADAMTSL4
ClinVarADAMTSL4
MonarchADAMTSL4
1000_GenomesADAMTSL4 
Exome Variant ServerADAMTSL4
GNOMAD BrowserENSG00000143382
Varsome BrowserADAMTSL4
ACMGADAMTSL4 variants
VarityQ6UY14
Genomic Variants (DGV)ADAMTSL4 [DGVbeta]
DECIPHERADAMTSL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTSL4 
Mutations
ICGC Data PortalADAMTSL4 
TCGA Data PortalADAMTSL4 
Broad Tumor PortalADAMTSL4
OASIS PortalADAMTSL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTSL4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DADAMTSL4
Mutations and Diseases : HGMDADAMTSL4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaADAMTSL4
DgiDB (Drug Gene Interaction Database)ADAMTSL4
DoCM (Curated mutations)ADAMTSL4
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTSL4
Cancer3DADAMTSL4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM225100    225200    610113   
Orphanet486   
DisGeNETADAMTSL4
MedgenADAMTSL4
Genetic Testing Registry ADAMTSL4
NextProtQ6UY14 [Medical]
GENETestsADAMTSL4
Target ValidationADAMTSL4
Huge Navigator ADAMTSL4 [HugePedia]
ClinGenADAMTSL4
Clinical trials, drugs, therapy
MyCancerGenomeADAMTSL4
Protein Interactions : CTDADAMTSL4
Pharm GKB GenePA134879921
PharosQ6UY14
Clinical trialADAMTSL4
Miscellaneous
canSAR (ICR)ADAMTSL4
HarmonizomeADAMTSL4
DataMed IndexADAMTSL4
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXADAMTSL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:41:32 CEST 2021

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